AR073677A1 - Derivados ciclicos de benzimidazol activadores de proteinquinasas de amp, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de diabetes tipo ii, obesidad y otras enfermedades. - Google Patents
Derivados ciclicos de benzimidazol activadores de proteinquinasas de amp, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de diabetes tipo ii, obesidad y otras enfermedades.Info
- Publication number
- AR073677A1 AR073677A1 ARP090103683A ARP090103683A AR073677A1 AR 073677 A1 AR073677 A1 AR 073677A1 AR P090103683 A ARP090103683 A AR P090103683A AR P090103683 A ARP090103683 A AR P090103683A AR 073677 A1 AR073677 A1 AR 073677A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- cycloalkyl
- aryl
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19433708P | 2008-09-26 | 2008-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073677A1 true AR073677A1 (es) | 2010-11-24 |
Family
ID=41395799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103683A AR073677A1 (es) | 2008-09-26 | 2009-09-24 | Derivados ciclicos de benzimidazol activadores de proteinquinasas de amp, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de diabetes tipo ii, obesidad y otras enfermedades. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8394969B2 (enExample) |
| EP (1) | EP3924343A1 (enExample) |
| JP (1) | JP5764064B2 (enExample) |
| CN (1) | CN102361857B (enExample) |
| AR (1) | AR073677A1 (enExample) |
| AU (1) | AU2009296820B2 (enExample) |
| CA (1) | CA2737694C (enExample) |
| MX (1) | MX2011003239A (enExample) |
| TW (1) | TWI393709B (enExample) |
| WO (1) | WO2010036613A1 (enExample) |
Families Citing this family (56)
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| EP2348857B1 (en) * | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102271511A (zh) | 2008-10-29 | 2011-12-07 | 默沙东公司 | 可用作抗糖尿病剂的新颖的环状苯并咪唑衍生物 |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| ES2679918T3 (es) | 2010-02-18 | 2018-08-31 | Vtv Therapeutics Llc | Derivados de imidazol condensados sustituidos, composiciones farmacéuticas y métodos de uso de los mismos |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8344137B2 (en) * | 2010-04-14 | 2013-01-01 | Hoffman-La Roche Inc. | 3,3-dimethyl tetrahydroquinoline derivatives |
| CA2811025C (en) | 2010-09-10 | 2018-07-17 | Shionogi & Co., Ltd. | Hetero ring-fused imidazole derivative having ampk activating effect |
| WO2012047772A2 (en) * | 2010-10-07 | 2012-04-12 | Schering Corporation | Imidazole derivatives |
| WO2012064569A1 (en) * | 2010-11-08 | 2012-05-18 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
| FR2968213B1 (fr) | 2010-12-03 | 2014-03-21 | Oreal | Utilisation d'une association amincissante |
| AR084174A1 (es) | 2010-12-21 | 2013-04-24 | Lilly Co Eli | Compuestos de imidazol-2-benzamida utiles para el tratamiento de osteoartritis y una composicion farmaceutica |
| MX348131B (es) * | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
| WO2012162635A1 (en) * | 2011-05-26 | 2012-11-29 | Sunovion Pharmaceuticals Inc. | Metabotropic glutamate receptors 5 modulators and methods of use thereof |
| WO2013011932A1 (ja) | 2011-07-15 | 2013-01-24 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するアザベンズイミダゾール誘導体 |
| TWI449702B (zh) * | 2012-07-11 | 2014-08-21 | Merck Sharp & Dohme | 作為抗糖尿病劑之新穎環氮雜苯并咪唑衍生物 |
| WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014031445A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| JP2015526468A (ja) * | 2012-08-22 | 2015-09-10 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 新規なアザベンズイミダゾールヘキサヒドロフロ［３，２−ｂ］フラン誘導体 |
| EP2888008B1 (en) | 2012-08-22 | 2018-12-26 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydrofuran derivatives |
| US9382243B2 (en) | 2012-08-22 | 2016-07-05 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydropyran derivatives |
| ES2755087T3 (es) * | 2012-08-22 | 2020-04-21 | Merck Sharp & Dohme | Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP |
| WO2014031441A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydrofuran derivatives |
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| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US10519115B2 (en) | 2013-11-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
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-
2009
- 2009-09-21 CN CN200980147275.5A patent/CN102361857B/zh active Active
- 2009-09-21 EP EP09792782.6A patent/EP3924343A1/en not_active Withdrawn
- 2009-09-21 US US12/563,782 patent/US8394969B2/en active Active
- 2009-09-21 MX MX2011003239A patent/MX2011003239A/es active IP Right Grant
- 2009-09-21 JP JP2011529149A patent/JP5764064B2/ja active Active
- 2009-09-21 CA CA2737694A patent/CA2737694C/en active Active
- 2009-09-21 WO PCT/US2009/057686 patent/WO2010036613A1/en not_active Ceased
- 2009-09-21 AU AU2009296820A patent/AU2009296820B2/en active Active
- 2009-09-24 TW TW098132353A patent/TWI393709B/zh not_active IP Right Cessation
- 2009-09-24 AR ARP090103683A patent/AR073677A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102361857A (zh) | 2012-02-22 |
| MX2011003239A (es) | 2011-04-28 |
| CN102361857B (zh) | 2015-09-16 |
| JP5764064B2 (ja) | 2015-08-12 |
| CA2737694A1 (en) | 2010-04-01 |
| US8394969B2 (en) | 2013-03-12 |
| CA2737694C (en) | 2013-07-02 |
| TWI393709B (zh) | 2013-04-21 |
| US20100081643A1 (en) | 2010-04-01 |
| EP3924343A1 (en) | 2021-12-22 |
| AU2009296820A1 (en) | 2010-04-01 |
| TW201016672A (en) | 2010-05-01 |
| WO2010036613A1 (en) | 2010-04-01 |
| WO2010036613A8 (en) | 2010-11-18 |
| AU2009296820B2 (en) | 2014-03-20 |
| JP2012503661A (ja) | 2012-02-09 |
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