GB8412065D0 - Preparation of carboxylic acid derivatives - Google Patents

Preparation of carboxylic acid derivatives

Info

Publication number
GB8412065D0
GB8412065D0 GB848412065A GB8412065A GB8412065D0 GB 8412065 D0 GB8412065 D0 GB 8412065D0 GB 848412065 A GB848412065 A GB 848412065A GB 8412065 A GB8412065 A GB 8412065A GB 8412065 D0 GB8412065 D0 GB 8412065D0
Authority
GB
United Kingdom
Prior art keywords
substituted
unsubstituted
alkyl
carboxylic acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB848412065A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to GB848412065A priority Critical patent/GB8412065D0/en
Publication of GB8412065D0 publication Critical patent/GB8412065D0/en
Priority to DE8585810210T priority patent/DE3583767D1/en
Priority to EP85810210A priority patent/EP0161220B1/en
Priority to AT85810210T priority patent/ATE66217T1/en
Priority to US06/731,252 priority patent/US4652653A/en
Priority to ES543005A priority patent/ES8602693A1/en
Priority to BR8502224A priority patent/BR8502224A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The reaction of 2-mercapto-benzothiazole or -benzimidazole with alpha , beta -unsaturated carboxylic acid derivatives in a strongly acid reaction medium gives compounds of the formula I <IMAGE> I in which X is sulfur or NH, each radical R independently of one another is H, alkyl, halogenalkyl, alkoxy, alkylthio, alkylsulfonyl, phenyl, alkylphenyl, phenylalkyl, cycloalkyl, halogen, NO2, CN, COOH, COOalkyl or a tertiary amino or carbamoyl group and R1, R2 and R3 independently of one another are H, alkyl, halogenalkyl, hydroxyalkyl, alkoxyalkyl unesterified or esterified carboxyl or carboxylalkyl, carbamyol, carbamyolalkyl or unsubstituted or substituted aryl or aralkyl, or R1 and R2 together are straight-chain or branched alkylene, which can be substituted by 1 or 2 carboxyl groups, R4 is unsubstituted or substituted amino, alkoxy, cycloalkoxy, aryloxy or aralkyloxy, or R2 and R4 together are CH2-CO-O- or -CH2CO-NR5- or R3 and R4 together are -CO-O- or -CO-NR5-, forming an anhydride or imide ring, wherein R5 is unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or hydrogen.
GB848412065A 1984-05-11 1984-05-11 Preparation of carboxylic acid derivatives Pending GB8412065D0 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB848412065A GB8412065D0 (en) 1984-05-11 1984-05-11 Preparation of carboxylic acid derivatives
DE8585810210T DE3583767D1 (en) 1984-05-11 1985-05-06 METHOD FOR PRODUCING BETA (BENZTHIAZOLYLTHIO) AND BETA (BENZIMIDAZOLYLTHIO) CARBONIC ACID DERIVATIVES.
EP85810210A EP0161220B1 (en) 1984-05-11 1985-05-06 Process for the preparation of beta-(benzothiazolylthio) and beta (benzimidazolylthio)carboxylic-acid derivatives
AT85810210T ATE66217T1 (en) 1984-05-11 1985-05-06 PROCESS FOR THE PRODUCTION OF BETA(BENZTHIAZOLYLTHIO) AND BETA(BENZIMIDAZOLYLTHIO) CARBONS|UREDERIVATIVES.
US06/731,252 US4652653A (en) 1984-05-11 1985-05-07 Process for the preparation of β-(benzothiazolylthio)- and β-(benzimidazolylthio)-carboxylic acid derivatives
ES543005A ES8602693A1 (en) 1984-05-11 1985-05-10 Process for the preparation of beta-(benzothiazolylthio) and beta (benzimidazolylthio)carboxylic-acid derivatives.
BR8502224A BR8502224A (en) 1984-05-11 1985-05-10 PROCESS FOR THE PREPARATION OF A COMPOUND

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848412065A GB8412065D0 (en) 1984-05-11 1984-05-11 Preparation of carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
GB8412065D0 true GB8412065D0 (en) 1984-06-20

Family

ID=10560807

Family Applications (1)

Application Number Title Priority Date Filing Date
GB848412065A Pending GB8412065D0 (en) 1984-05-11 1984-05-11 Preparation of carboxylic acid derivatives

Country Status (7)

Country Link
US (1) US4652653A (en)
EP (1) EP0161220B1 (en)
AT (1) ATE66217T1 (en)
BR (1) BR8502224A (en)
DE (1) DE3583767D1 (en)
ES (1) ES8602693A1 (en)
GB (1) GB8412065D0 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313322D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Heterocyclic-(cyclo)aliphatic carboxylic acids
US5347008A (en) * 1983-05-14 1994-09-13 Ciba-Geigy Corporation Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
EP0894793A1 (en) 1997-07-30 1999-02-03 Ciba SC Holding AG Phosphorus-free multifunctional lubricant additives
AU2009296820B2 (en) 2008-09-26 2014-03-20 Merck Sharp & Dohme Llc Novel cyclic benzimidazole derivatives useful anti-diabetic agents
MX2011004258A (en) 2008-10-22 2011-06-01 Merck Sharp & Dohme Novel cyclic benzimidazole derivatives useful anti-diabetic agents.
EP2352374B1 (en) 2008-10-29 2014-09-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN104649999A (en) * 2013-11-25 2015-05-27 刘现梅 Water-soluble 2-mercaptobenzothiazole derivative and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725364A (en) * 1952-12-31 1955-11-29 Monsanto Chemicals Vinyl halide polymers plasticized with diesters of acid derivatives of 2-benzothiazolyl mercaptan
US3136689A (en) * 1959-12-28 1964-06-09 Monsanto Co Heterocyclic esters effective against micro-organisms
US3161495A (en) * 1959-12-28 1964-12-15 Monsanto Co Method of inhibiting growth of undesirable plants
US3068239A (en) * 1959-12-28 1962-12-11 Monsanto Chemicals Benzothiazole-, benzoxazole- and benzimidazole-2-thioacrylates and process
DE3216416A1 (en) * 1982-05-03 1983-11-03 Bayer Ag, 5090 Leverkusen HETEROARYLTHIOVINYL COMPOUNDS, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PEST CONTROL
GB8313321D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Preparation of mercaptan substituted carboxylic acids
GB8313322D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Heterocyclic-(cyclo)aliphatic carboxylic acids

Also Published As

Publication number Publication date
ES543005A0 (en) 1985-12-16
EP0161220B1 (en) 1991-08-14
EP0161220A3 (en) 1987-04-29
BR8502224A (en) 1986-01-14
ATE66217T1 (en) 1991-08-15
ES8602693A1 (en) 1985-12-16
DE3583767D1 (en) 1991-09-19
EP0161220A2 (en) 1985-11-13
US4652653A (en) 1987-03-24

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