AU609377B2 - New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them - Google Patents

New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them

Info

Publication number
AU609377B2
AU609377B2 AU60509/86A AU6050986A AU609377B2 AU 609377 B2 AU609377 B2 AU 609377B2 AU 60509/86 A AU60509/86 A AU 60509/86A AU 6050986 A AU6050986 A AU 6050986A AU 609377 B2 AU609377 B2 AU 609377B2
Authority
AU
Australia
Prior art keywords
derivaties
esterified
medicaments
intermediates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU60509/86A
Other versions
AU6050986A (en
Inventor
Francois Clemence
Francoise Delevallee
Odile Le Martret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU6050986A publication Critical patent/AU6050986A/en
Application granted granted Critical
Publication of AU609377B2 publication Critical patent/AU609377B2/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of formula (I): <IMAGE> in which X at 5, 6, 7 or 8 is H, halogen, (C1-5) alkyl, (C1-4) alkoxy, -CF3, -SCF3, -OCF3, R1 is phenyl optionally substituted by at least OH, (C1-5) alkyl, (C1-4) alkoxy, CF3, NO2, halogen or a heterocyclic radical optionally substituted by a (C1-4) alkyl radical, R2 and R3 which are identical or different are H, (C1-4) alkyl, aryl, -C(:O)-R5, R5 being (C1-4) alkyl or aryl. R4 is H, (C1-4) alkyl or aryl, and their addition salts with acids and bases.
AU60509/86A 1985-07-25 1986-07-24 New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them Ceased AU609377B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8511389A FR2585356B1 (en) 1985-07-25 1985-07-25 NOVEL DERIVATIVES OF 4-OH QUINOLEINE CARBOXYLIC ACID SUBSTITUTED IN 2 BY TWO POSSIBLE ETHERIFIED OR ESTERIFIED HYDROXYL FUNCTIONS, THEIR PREPARATION PROCESSES, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS
FR8511389 1985-07-25

Publications (2)

Publication Number Publication Date
AU6050986A AU6050986A (en) 1987-01-29
AU609377B2 true AU609377B2 (en) 1991-05-02

Family

ID=9321642

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60509/86A Ceased AU609377B2 (en) 1985-07-25 1986-07-24 New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them

Country Status (16)

Country Link
EP (1) EP0214004B1 (en)
JP (1) JPH0710863B2 (en)
KR (1) KR940003759B1 (en)
AT (1) ATE87625T1 (en)
AU (1) AU609377B2 (en)
CA (1) CA1262903A (en)
DE (1) DE3688161T2 (en)
DK (1) DK172034B1 (en)
ES (1) ES2000739A6 (en)
FI (1) FI86426C (en)
FR (1) FR2585356B1 (en)
GR (1) GR861924B (en)
HU (1) HU202526B (en)
PT (1) PT83064B (en)
SU (1) SU1584749A3 (en)
ZA (1) ZA865260B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845105A (en) * 1984-10-30 1989-07-04 Roussel Uclaf 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
US5438344A (en) * 1990-11-05 1995-08-01 Oliva; Anthony Portable video book
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
JP3337992B2 (en) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 5-Substituted picolinic acid compound and method for producing the same
JP4804590B1 (en) 2010-04-14 2011-11-02 帝人テクノプロダクツ株式会社 Meta-type wholly aromatic polyamide fiber

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8611882A (en) * 1981-07-17 1983-01-20 Roussel-Uclaf Quinoline derivatives
AU4411785A (en) * 1984-06-25 1986-01-02 Roussel-Uclaf 4-hydroxy-3-quinoline derivatives
AU7068987A (en) * 1986-03-27 1987-10-08 Warner-Lambert Company Chewing gum with soy flavour enhancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS593996B2 (en) * 1975-11-25 1984-01-27 キツセイ薬品工業株式会社 2-styryl-3,1-benzoxazin-4-one derivative and method for producing the same
JPS593995B2 (en) * 1975-12-31 1984-01-27 キツセイヤクヒンコウギヨウ カブシキガイシヤ 2- Styryl -3,1- Benzoxazine -4-
FR2530633A1 (en) * 1982-06-03 1984-01-27 Roussel Uclaf NOVEL SUBSTITUTED 2-SUBSTITUTED 4-HYDROXY 3-QUINOLINE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION, THEIR USE AS A MEDICINAL PRODUCT, AND THE COMPOSITIONS COMPRISING THE SAME

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8611882A (en) * 1981-07-17 1983-01-20 Roussel-Uclaf Quinoline derivatives
AU4411785A (en) * 1984-06-25 1986-01-02 Roussel-Uclaf 4-hydroxy-3-quinoline derivatives
AU7068987A (en) * 1986-03-27 1987-10-08 Warner-Lambert Company Chewing gum with soy flavour enhancer

Also Published As

Publication number Publication date
DE3688161D1 (en) 1993-05-06
FI86426C (en) 1992-08-25
KR940003759B1 (en) 1994-04-30
DK351886A (en) 1987-01-26
DK351886D0 (en) 1986-07-24
FI86426B (en) 1992-05-15
ATE87625T1 (en) 1993-04-15
ES2000739A6 (en) 1988-03-16
EP0214004A2 (en) 1987-03-11
EP0214004B1 (en) 1993-03-31
FR2585356B1 (en) 1987-10-23
DE3688161T2 (en) 1993-10-14
JPH0710863B2 (en) 1995-02-08
EP0214004A3 (en) 1989-04-05
PT83064B (en) 1989-02-28
ZA865260B (en) 1987-09-30
KR870001206A (en) 1987-03-12
GR861924B (en) 1986-11-25
HUT43598A (en) 1987-11-30
FI863040A0 (en) 1986-07-24
FR2585356A1 (en) 1987-01-30
JPS6229585A (en) 1987-02-07
FI863040A (en) 1987-01-26
CA1262903A (en) 1989-11-14
HU202526B (en) 1991-03-28
DK172034B1 (en) 1997-09-22
SU1584749A3 (en) 1990-08-07
AU6050986A (en) 1987-01-29
PT83064A (en) 1986-08-01

Similar Documents

Publication Publication Date Title
ES8603242A1 (en) Nitromethylene derivatives, intermediates, and process for their preparation as insecticides.
SE8102731L (en) AMINOCYCLOPENTANAL ACID ACIDS AND ESTERS AND PREPARATION OF THEM, AND PHARMACEUTICAL PREPARATION
FI965020A0 (en) New compounds, processes for their preparation and anti-tumor agents
ES2005746A6 (en) Process for the preparation of aryl-piperidine esters.
AU609377B2 (en) New derivaties of 4-OH quinoline carboxylic acid substituted in position 2 by a possibly etherified or esterified dihydroxyl group, the process and intermediates for preparation, their application as medicaments and the compositions containing them
AR241136A2 (en) Benzothiazolesulfonamide derivatives, their preparation and ophthalmic compositions containing said derivatives
ES543154A0 (en) METHOD OF PREPARING A B-CARBOLIN-3-CARBO- XYLIC ACID DERIVATIVE
ES2153457T3 (en) AMINO-ALQUIL-BENZOXAZOLINONAS AND BENZOTIAZOLINONAS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK408781A (en) METHOD FOR PREPARING 2- (4- (DIPHENYLMETHYL) -1-PIPERIDINYL) ACETIC ACIDS OR AMIDES THEREOF
DE69110107D1 (en) Process for the preparation of 3-alkoxymethyl cephalosporin derivatives.
JPS55133366A (en) Thiazole derivative
DK133083A (en) METHOD OF PREPARING PHENYLALKYLOXIRANCARBOXYL ACID
NO865121D0 (en) PROCEDURE FOR THE PREPARATION OF 5- OR 6-SUBSTITUTED-BETA-CARBOLIN-3-CARBOXYLIC ACIDS.
SE8301785L (en) SET TO MAKE 2-THIOPHENIC ACETIC ACID DERIVATIVES AND INTERMEDIATES REQUIRED FOR THEIR PREPARATION
ES8204729A1 (en) Process for the preparation of 5&#39;-substituted 2-(3&#39;-thienyl)propionic acids
HUT37126A (en) Pocess for the production of new amino-ethyl-imidazola-derivatives, as well as of pharmaceutical preparations containing thes compounds
FI941650A0 (en) New fluoroquinoline-3-carboxylic acid derivatives and their preparation
FI870098A (en) NEW PREPARATIONS, PHARMACEUTICAL FORM FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS, VILKA INNEHAOLLER DESAMMA.
JPS557255A (en) Thiazolidine derivative
GB2003874A (en) Diarylbutylpiperazines
JPS54119428A (en) Novel benzoic acid derivative
FI833971A0 (en) NYA SEMIKARBAZIDER, DERAS FRAMSTAELLNING OCH ANVAENDNING
JPS54135763A (en) Azetidinone derivative having substituted amino group, its salt, and their preparation
JPS57154182A (en) Omega-piperazinyl-alpha-hydroxyalkylalkylene dioxybenzenes and their acid addition salts
JPS6422854A (en) Quinoline-3-carboxylic acid derivative

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL

MK14 Patent ceased section 143(a) (annual fees not paid) or expired