ZA865260B - Derivatives of 4-oh quinoline carboxylic acid substituted at position 2 by a dihydroxylated group possibly etherified or esterified,the process and the intermediates for their preparation,their application as medicaments and the compositions containing them - Google Patents

Derivatives of 4-oh quinoline carboxylic acid substituted at position 2 by a dihydroxylated group possibly etherified or esterified,the process and the intermediates for their preparation,their application as medicaments and the compositions containing them

Info

Publication number
ZA865260B
ZA865260B ZA865260A ZA865260A ZA865260B ZA 865260 B ZA865260 B ZA 865260B ZA 865260 A ZA865260 A ZA 865260A ZA 865260 A ZA865260 A ZA 865260A ZA 865260 B ZA865260 B ZA 865260B
Authority
ZA
South Africa
Prior art keywords
esterified
medicaments
intermediates
derivatives
preparation
Prior art date
Application number
ZA865260A
Inventor
Francois Clemence
Odile Le Martret
Francoise Delevallee
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA865260B publication Critical patent/ZA865260B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Compounds of formula (I): <IMAGE> in which X at 5, 6, 7 or 8 is H, halogen, (C1-5) alkyl, (C1-4) alkoxy, -CF3, -SCF3, -OCF3, R1 is phenyl optionally substituted by at least OH, (C1-5) alkyl, (C1-4) alkoxy, CF3, NO2, halogen or a heterocyclic radical optionally substituted by a (C1-4) alkyl radical, R2 and R3 which are identical or different are H, (C1-4) alkyl, aryl, -C(:O)-R5, R5 being (C1-4) alkyl or aryl. R4 is H, (C1-4) alkyl or aryl, and their addition salts with acids and bases.
ZA865260A 1985-07-25 1986-07-15 Derivatives of 4-oh quinoline carboxylic acid substituted at position 2 by a dihydroxylated group possibly etherified or esterified,the process and the intermediates for their preparation,their application as medicaments and the compositions containing them ZA865260B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8511389A FR2585356B1 (en) 1985-07-25 1985-07-25 NOVEL DERIVATIVES OF 4-OH QUINOLEINE CARBOXYLIC ACID SUBSTITUTED IN 2 BY TWO POSSIBLE ETHERIFIED OR ESTERIFIED HYDROXYL FUNCTIONS, THEIR PREPARATION PROCESSES, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS

Publications (1)

Publication Number Publication Date
ZA865260B true ZA865260B (en) 1987-09-30

Family

ID=9321642

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA865260A ZA865260B (en) 1985-07-25 1986-07-15 Derivatives of 4-oh quinoline carboxylic acid substituted at position 2 by a dihydroxylated group possibly etherified or esterified,the process and the intermediates for their preparation,their application as medicaments and the compositions containing them

Country Status (16)

Country Link
EP (1) EP0214004B1 (en)
JP (1) JPH0710863B2 (en)
KR (1) KR940003759B1 (en)
AT (1) ATE87625T1 (en)
AU (1) AU609377B2 (en)
CA (1) CA1262903A (en)
DE (1) DE3688161T2 (en)
DK (1) DK172034B1 (en)
ES (1) ES2000739A6 (en)
FI (1) FI86426C (en)
FR (1) FR2585356B1 (en)
GR (1) GR861924B (en)
HU (1) HU202526B (en)
PT (1) PT83064B (en)
SU (1) SU1584749A3 (en)
ZA (1) ZA865260B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845105A (en) * 1984-10-30 1989-07-04 Roussel Uclaf 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
US5438344A (en) * 1990-11-05 1995-08-01 Oliva; Anthony Portable video book
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
JP3337992B2 (en) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 5-Substituted picolinic acid compound and method for producing the same
JP4804590B1 (en) 2010-04-14 2011-11-02 帝人テクノプロダクツ株式会社 Meta-type wholly aromatic polyamide fiber

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS593996B2 (en) * 1975-11-25 1984-01-27 キツセイ薬品工業株式会社 2-styryl-3,1-benzoxazin-4-one derivative and method for producing the same
JPS593995B2 (en) * 1975-12-31 1984-01-27 キツセイヤクヒンコウギヨウ カブシキガイシヤ 2- Styryl -3,1- Benzoxazine -4-
FR2509728A1 (en) * 1981-07-17 1983-01-21 Roussel Uclaf NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2530633A1 (en) * 1982-06-03 1984-01-27 Roussel Uclaf NOVEL SUBSTITUTED 2-SUBSTITUTED 4-HYDROXY 3-QUINOLINE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION, THEIR USE AS A MEDICINAL PRODUCT, AND THE COMPOSITIONS COMPRISING THE SAME
FR2566405B1 (en) * 1984-06-25 1986-09-26 Roussel Uclaf NOVEL DERIVATIVES OF 4-HYDROXY 3-QUINOLEINE CARBOXYLIC ACID SUBSTITUTED IN 2 BY AN AMINE FUNCTION, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES NEW OBTAINED
ZA871658B (en) * 1986-03-27 1987-08-28 Warner-Lambert Company Chewing gum and confectionery compositions containing a soy flavor enhancer

Also Published As

Publication number Publication date
CA1262903A (en) 1989-11-14
FI86426C (en) 1992-08-25
PT83064A (en) 1986-08-01
HUT43598A (en) 1987-11-30
ATE87625T1 (en) 1993-04-15
EP0214004A2 (en) 1987-03-11
FR2585356B1 (en) 1987-10-23
SU1584749A3 (en) 1990-08-07
AU609377B2 (en) 1991-05-02
EP0214004A3 (en) 1989-04-05
HU202526B (en) 1991-03-28
DE3688161T2 (en) 1993-10-14
PT83064B (en) 1989-02-28
DK351886D0 (en) 1986-07-24
DK351886A (en) 1987-01-26
FI863040A (en) 1987-01-26
GR861924B (en) 1986-11-25
JPH0710863B2 (en) 1995-02-08
AU6050986A (en) 1987-01-29
FI863040A0 (en) 1986-07-24
EP0214004B1 (en) 1993-03-31
DK172034B1 (en) 1997-09-22
FI86426B (en) 1992-05-15
DE3688161D1 (en) 1993-05-06
ES2000739A6 (en) 1988-03-16
JPS6229585A (en) 1987-02-07
FR2585356A1 (en) 1987-01-30
KR870001206A (en) 1987-03-12
KR940003759B1 (en) 1994-04-30

Similar Documents

Publication Publication Date Title
DK58292A (en) INTERMEDIATE APPLICABLE 4 (5) IMIDAZOLD DERIVATIVES
FI965020A0 (en) New compounds, processes for their preparation and anti-tumor agents
ES2031569T3 (en) DERIVATIVES OF QUINOLINOCARBOXILIC ACIDS.
ES2000604A6 (en) Process for the preparation of aryl-piperidine esters.
ES2040213T3 (en) NEW DERIVATIVES OF 3-OXADIAZOL- AND 3- (ESTER OF CARBOXYLIC ACID) -BETA-CARBOLINE, ITS PREPARATION AND ITS USE AS MEDICINES.
ZA865260B (en) Derivatives of 4-oh quinoline carboxylic acid substituted at position 2 by a dihydroxylated group possibly etherified or esterified,the process and the intermediates for their preparation,their application as medicaments and the compositions containing them
ATE6252T1 (en) PROCESSES AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 3,3&#39;-AZO-BIS(6-HYDROXYBENZOACID).
EP0161220A3 (en) Process for the preparation of beta-(benzothiazolylthio) and beta (benzimidazolylthio)carboxylic-acid derivatives
DE69110107D1 (en) Process for the preparation of 3-alkoxymethyl cephalosporin derivatives.
JPS55133366A (en) Thiazole derivative
DK133083A (en) METHOD OF PREPARING PHENYLALKYLOXIRANCARBOXYL ACID
SE8301785L (en) SET TO MAKE 2-THIOPHENIC ACETIC ACID DERIVATIVES AND INTERMEDIATES REQUIRED FOR THEIR PREPARATION
NO865121D0 (en) PROCEDURE FOR THE PREPARATION OF 5- OR 6-SUBSTITUTED-BETA-CARBOLIN-3-CARBOXYLIC ACIDS.
HUT37126A (en) Pocess for the production of new amino-ethyl-imidazola-derivatives, as well as of pharmaceutical preparations containing thes compounds
FI941650A0 (en) New fluoroquinoline-3-carboxylic acid derivatives and their preparation
JPS6490184A (en) Pyridonecarboxylic acids
GB2003874A (en) Diarylbutylpiperazines
ATE53008T1 (en) PROCESS FOR THE PREPARATION OF N-ACYL-2,3DEHYDROAMINOCARBONS|UREESTERS.
FI833971A (en) NYA SEMIKARBAZIDER, DERAS FRAMSTAELLNING OCH ANVAENDNING
FI870098A (en) NEW PREPARATIONS, PHARMACEUTICAL FORM FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS, VILKA INNEHAOLLER DESAMMA.