CN102245607B - 吗啉代嘌呤衍生物 - Google Patents

吗啉代嘌呤衍生物 Download PDF

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Publication number
CN102245607B
CN102245607B CN200980151585.4A CN200980151585A CN102245607B CN 102245607 B CN102245607 B CN 102245607B CN 200980151585 A CN200980151585 A CN 200980151585A CN 102245607 B CN102245607 B CN 102245607B
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CN
China
Prior art keywords
compound
morpholin
group
purin
amine
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Expired - Fee Related
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CN200980151585.4A
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English (en)
Chinese (zh)
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CN102245607A (zh
Inventor
中山清
杉田和幸
濑户口正树
冨永裕一
斎藤正规
小田桐高志
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Publication of CN102245607A publication Critical patent/CN102245607A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980151585.4A 2008-10-14 2009-10-13 吗啉代嘌呤衍生物 Expired - Fee Related CN102245607B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2008264797 2008-10-14
JP2008-264797 2008-10-14
JP2009121690 2009-05-20
JP2009-121690 2009-05-20
PCT/JP2009/067738 WO2010044401A1 (ja) 2008-10-14 2009-10-13 モルホリノプリン誘導体

Publications (2)

Publication Number Publication Date
CN102245607A CN102245607A (zh) 2011-11-16
CN102245607B true CN102245607B (zh) 2014-07-02

Family

ID=42106564

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980151585.4A Expired - Fee Related CN102245607B (zh) 2008-10-14 2009-10-13 吗啉代嘌呤衍生物

Country Status (21)

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US (2) US8097622B2 (enExample)
EP (1) EP2336132B1 (enExample)
JP (1) JP5090423B2 (enExample)
KR (1) KR101614976B1 (enExample)
CN (1) CN102245607B (enExample)
AU (1) AU2009304789B2 (enExample)
BR (1) BRPI0920199A2 (enExample)
CA (1) CA2740471C (enExample)
CO (1) CO6362009A2 (enExample)
DK (1) DK2336132T3 (enExample)
ES (1) ES2452541T3 (enExample)
IL (1) IL212278A (enExample)
MX (1) MX2011003490A (enExample)
MY (1) MY156456A (enExample)
NZ (1) NZ592761A (enExample)
PL (1) PL2336132T3 (enExample)
PT (1) PT2336132E (enExample)
RU (1) RU2490269C2 (enExample)
TW (1) TWI378933B (enExample)
WO (1) WO2010044401A1 (enExample)
ZA (1) ZA201102449B (enExample)

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CN102260263A (zh) * 2010-05-26 2011-11-30 四川大学 一类二苯胺基嘌呤衍生物及制备方法和医药用途
CN103003279B (zh) 2010-07-14 2015-09-23 弗·哈夫曼-拉罗切有限公司 对PI3K P110δ具有选择性的嘌呤化合物及其使用方法
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CN103012284A (zh) * 2012-12-26 2013-04-03 无锡捷化医药科技有限公司 一种2-氨基-5-溴嘧啶类化合物的制备方法
TW201521791A (zh) * 2013-05-13 2015-06-16 Daiichi Sankyo Co Ltd ５－｛８－［（３ｒ）－４－乙醯基－３－甲基哌－１－基］－６－□啉－４－基－９－（２，２，２－三氟乙基）－９ｈ－嘌呤－２－基｝嘧啶－２－胺、及其藥理容許鹽之新穎結晶、及其製造方法
TW201520215A (zh) * 2013-05-13 2015-06-01 Daiichi Sankyo Co Ltd Ｎ－□啉基嘌呤衍生物之製造方法
CA2928568A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Combinatorial methods to improve the therapeutic benefit of bisantrene
WO2015049369A1 (en) * 2013-10-04 2015-04-09 Universitaet Basel Conformationally restricted pi3k and mtor inhibitors
EP3277682B1 (en) 2015-03-30 2019-04-24 Daiichi Sankyo Company, Limited 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors
CN108602825A (zh) * 2016-02-05 2018-09-28 中央研究院 具有抗癌活性的嘌呤化合物
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
CN110036109A (zh) 2016-12-02 2019-07-19 第一三共株式会社 新颖的内-β-N-乙酰基氨基葡糖苷酶
EP3360865A1 (en) 2017-02-13 2018-08-15 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272
TWI837231B (zh) 2018-11-29 2024-04-01 日商第一三共股份有限公司 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途
CN113368114B (zh) * 2020-03-10 2022-04-22 四川大学 一种吗啉嘧啶类化合物的抗肿瘤应用
JP2024511996A (ja) * 2021-03-17 2024-03-18 タンゴ セラピューティクス， インコーポレイテッド 抗がん剤としてのプリン誘導体

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Also Published As

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EP2336132A4 (en) 2012-03-21
PT2336132E (pt) 2014-04-02
WO2010044401A1 (ja) 2010-04-22
RU2011119525A (ru) 2012-11-27
ES2452541T3 (es) 2014-04-01
NZ592761A (en) 2012-05-25
CN102245607A (zh) 2011-11-16
CO6362009A2 (es) 2012-01-20
DK2336132T3 (da) 2014-04-07
JP2011001339A (ja) 2011-01-06
AU2009304789A1 (en) 2010-04-22
US8097622B2 (en) 2012-01-17
ZA201102449B (en) 2011-12-28
PL2336132T3 (pl) 2014-06-30
CA2740471C (en) 2013-09-17
US8309546B2 (en) 2012-11-13
EP2336132B1 (en) 2014-01-01
TW201018690A (en) 2010-05-16
IL212278A0 (en) 2011-06-30
BRPI0920199A2 (pt) 2019-09-24
MX2011003490A (es) 2011-04-21
MY156456A (en) 2016-02-26
CA2740471A1 (en) 2010-04-22
TWI378933B (en) 2012-12-11
HK1158189A1 (en) 2012-07-13
IL212278A (en) 2016-07-31
KR20110067038A (ko) 2011-06-20
EP2336132A1 (en) 2011-06-22
KR101614976B1 (ko) 2016-04-22
RU2490269C2 (ru) 2013-08-20
US20100130492A1 (en) 2010-05-27
JP5090423B2 (ja) 2012-12-05
AU2009304789B2 (en) 2012-04-05
US20120071476A1 (en) 2012-03-22

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