CA2740471C - Morpholinopurine derivatives - Google Patents

Morpholinopurine derivatives Download PDF

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Publication number
CA2740471C
CA2740471C CA2740471A CA2740471A CA2740471C CA 2740471 C CA2740471 C CA 2740471C CA 2740471 A CA2740471 A CA 2740471A CA 2740471 A CA2740471 A CA 2740471A CA 2740471 C CA2740471 C CA 2740471C
Authority
CA
Canada
Prior art keywords
group
substituents
compound
alkylamino
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2740471A
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English (en)
French (fr)
Other versions
CA2740471A1 (en
Inventor
Kiyoshi Nakayama
Kazuyuki Sugita
Masaki Setoguchi
Yuichi Tominaga
Masanori Saitou
Takashi Odagiri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
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Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CA2740471A1 publication Critical patent/CA2740471A1/en
Application granted granted Critical
Publication of CA2740471C publication Critical patent/CA2740471C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2740471A 2008-10-14 2009-10-13 Morpholinopurine derivatives Expired - Fee Related CA2740471C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2008264797 2008-10-14
JP2008-264797 2008-10-14
JP2009121690 2009-05-20
JP2009-121690 2009-05-20
PCT/JP2009/067738 WO2010044401A1 (ja) 2008-10-14 2009-10-13 モルホリノプリン誘導体

Publications (2)

Publication Number Publication Date
CA2740471A1 CA2740471A1 (en) 2010-04-22
CA2740471C true CA2740471C (en) 2013-09-17

Family

ID=42106564

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2740471A Expired - Fee Related CA2740471C (en) 2008-10-14 2009-10-13 Morpholinopurine derivatives

Country Status (21)

Country Link
US (2) US8097622B2 (enExample)
EP (1) EP2336132B1 (enExample)
JP (1) JP5090423B2 (enExample)
KR (1) KR101614976B1 (enExample)
CN (1) CN102245607B (enExample)
AU (1) AU2009304789B2 (enExample)
BR (1) BRPI0920199A2 (enExample)
CA (1) CA2740471C (enExample)
CO (1) CO6362009A2 (enExample)
DK (1) DK2336132T3 (enExample)
ES (1) ES2452541T3 (enExample)
IL (1) IL212278A (enExample)
MX (1) MX2011003490A (enExample)
MY (1) MY156456A (enExample)
NZ (1) NZ592761A (enExample)
PL (1) PL2336132T3 (enExample)
PT (1) PT2336132E (enExample)
RU (1) RU2490269C2 (enExample)
TW (1) TWI378933B (enExample)
WO (1) WO2010044401A1 (enExample)
ZA (1) ZA201102449B (enExample)

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CN102260263A (zh) * 2010-05-26 2011-11-30 四川大学 一类二苯胺基嘌呤衍生物及制备方法和医药用途
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CN103012284A (zh) * 2012-12-26 2013-04-03 无锡捷化医药科技有限公司 一种2-氨基-5-溴嘧啶类化合物的制备方法
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TWI837231B (zh) 2018-11-29 2024-04-01 日商第一三共股份有限公司 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途
CN113368114B (zh) * 2020-03-10 2022-04-22 四川大学 一种吗啉嘧啶类化合物的抗肿瘤应用
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Also Published As

Publication number Publication date
JP2011001339A (ja) 2011-01-06
US8309546B2 (en) 2012-11-13
US20120071476A1 (en) 2012-03-22
CN102245607B (zh) 2014-07-02
TW201018690A (en) 2010-05-16
BRPI0920199A2 (pt) 2019-09-24
MX2011003490A (es) 2011-04-21
RU2011119525A (ru) 2012-11-27
JP5090423B2 (ja) 2012-12-05
MY156456A (en) 2016-02-26
CN102245607A (zh) 2011-11-16
ZA201102449B (en) 2011-12-28
AU2009304789A1 (en) 2010-04-22
US20100130492A1 (en) 2010-05-27
IL212278A0 (en) 2011-06-30
KR101614976B1 (ko) 2016-04-22
KR20110067038A (ko) 2011-06-20
TWI378933B (en) 2012-12-11
PT2336132E (pt) 2014-04-02
RU2490269C2 (ru) 2013-08-20
DK2336132T3 (da) 2014-04-07
US8097622B2 (en) 2012-01-17
HK1158189A1 (en) 2012-07-13
CA2740471A1 (en) 2010-04-22
ES2452541T3 (es) 2014-04-01
EP2336132A1 (en) 2011-06-22
IL212278A (en) 2016-07-31
EP2336132A4 (en) 2012-03-21
WO2010044401A1 (ja) 2010-04-22
NZ592761A (en) 2012-05-25
AU2009304789B2 (en) 2012-04-05
EP2336132B1 (en) 2014-01-01
PL2336132T3 (pl) 2014-06-30
CO6362009A2 (es) 2012-01-20

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