MY156456A - Morpholinopurine derivatives - Google Patents
Morpholinopurine derivativesInfo
- Publication number
- MY156456A MY156456A MYPI2011001420A MYPI20111420A MY156456A MY 156456 A MY156456 A MY 156456A MY PI2011001420 A MYPI2011001420 A MY PI2011001420A MY PI20111420 A MYPI20111420 A MY PI20111420A MY 156456 A MY156456 A MY 156456A
- Authority
- MY
- Malaysia
- Prior art keywords
- mtor
- pi3k
- tumor activity
- inhibits
- exhibits anti
- Prior art date
Links
- IBVOXEAVUMUIBU-UHFFFAOYSA-N 4-(7h-purin-2-yl)morpholine Chemical class C1COCCN1C1=NC=C(NC=N2)C2=N1 IBVOXEAVUMUIBU-UHFFFAOYSA-N 0.000 title 1
- 108091007960 PI3Ks Proteins 0.000 abstract 3
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 3
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 3
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 abstract 3
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 abstract 3
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008264797 | 2008-10-14 | ||
| JP2009121690 | 2009-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY156456A true MY156456A (en) | 2016-02-26 |
Family
ID=42106564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2011001420A MY156456A (en) | 2008-10-14 | 2009-10-13 | Morpholinopurine derivatives |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8097622B2 (enExample) |
| EP (1) | EP2336132B1 (enExample) |
| JP (1) | JP5090423B2 (enExample) |
| KR (1) | KR101614976B1 (enExample) |
| CN (1) | CN102245607B (enExample) |
| AU (1) | AU2009304789B2 (enExample) |
| BR (1) | BRPI0920199A2 (enExample) |
| CA (1) | CA2740471C (enExample) |
| CO (1) | CO6362009A2 (enExample) |
| DK (1) | DK2336132T3 (enExample) |
| ES (1) | ES2452541T3 (enExample) |
| IL (1) | IL212278A (enExample) |
| MX (1) | MX2011003490A (enExample) |
| MY (1) | MY156456A (enExample) |
| NZ (1) | NZ592761A (enExample) |
| PL (1) | PL2336132T3 (enExample) |
| PT (1) | PT2336132E (enExample) |
| RU (1) | RU2490269C2 (enExample) |
| TW (1) | TWI378933B (enExample) |
| WO (1) | WO2010044401A1 (enExample) |
| ZA (1) | ZA201102449B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2279188B1 (en) * | 2008-05-30 | 2015-01-28 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| CN102711766B (zh) * | 2009-11-12 | 2014-06-04 | 霍夫曼-拉罗奇有限公司 | N-9-取代的嘌呤化合物、组合物和使用方法 |
| CN102260263A (zh) * | 2010-05-26 | 2011-11-30 | 四川大学 | 一类二苯胺基嘌呤衍生物及制备方法和医药用途 |
| KR101531117B1 (ko) | 2010-07-14 | 2015-06-23 | 에프. 호프만-라 로슈 아게 | Pi3k p110 델타에 대해 선택적인 퓨린 화합물, 및 사용 방법 |
| BR112013014914B8 (pt) | 2010-12-16 | 2020-08-04 | Hoffmann La Roche | composto, composição farmacêutica e uso de um composto |
| KR20140090218A (ko) | 2011-10-28 | 2014-07-16 | 노파르티스 아게 | 신규 퓨린 유도체 및 질환의 치료에서의 그의 용도 |
| CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
| WO2014185368A1 (ja) * | 2013-05-13 | 2014-11-20 | 第一三共株式会社 | ５－｛８－［（３ｒ）－４－アセチル－３－メチルピペラジン－１－イル］－６－モルホリン－４－イル－９－（２，２，２－トリフルオロエチル）－９ｈ－プリン－２－イル｝ピリミジン－２－アミン、およびその薬理上許容される塩の新規な結晶、およびその製造方法 |
| TW201520215A (zh) * | 2013-05-13 | 2015-06-01 | Daiichi Sankyo Co Ltd | Ｎ－□啉基嘌呤衍生物之製造方法 |
| KR20160104612A (ko) | 2013-07-26 | 2016-09-05 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조성물 |
| ES2721302T3 (es) * | 2013-10-04 | 2019-07-30 | Univ Basel | Inhibidores de PI3k y mTOR conformacionalmente restringidos |
| AU2016242080B2 (en) | 2015-03-30 | 2019-09-19 | Daiichi Sankyo Company, Limited | 6-morpholinyl-2-pyrazolyl-9H-purine derivatives and their use as PI3K inhibitors |
| CN108602825A (zh) * | 2016-02-05 | 2018-09-28 | 中央研究院 | 具有抗癌活性的嘌呤化合物 |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| ES2911522T3 (es) | 2016-12-02 | 2022-05-19 | Daiichi Sankyo Co Ltd | Novedosa endo-ß-n-acetilglucosaminidasa |
| EP3360865A1 (en) | 2017-02-13 | 2018-08-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272 |
| TWI837231B (zh) | 2018-11-29 | 2024-04-01 | 日商第一三共股份有限公司 | 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途 |
| CN113368114B (zh) * | 2020-03-10 | 2022-04-22 | 四川大学 | 一种吗啉嘧啶类化合物的抗肿瘤应用 |
| BR112023018799A2 (pt) * | 2021-03-17 | 2023-12-12 | Medivir Ab | Derivados de purina como agentes anticâncer |
Family Cites Families (77)
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|---|---|---|---|---|
| GB864145A (en) * | 1959-06-02 | 1961-03-29 | Thomae Gmbh Dr K | Novel purines and a process for their manufacture |
| WO2001083456A1 (en) | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Condensed heteroaryl derivatives |
| US6608053B2 (en) | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| JP3810017B2 (ja) | 2000-04-27 | 2006-08-16 | アステラス製薬株式会社 | 縮合ヘテロアリール誘導体 |
| PT1389617E (pt) | 2001-04-27 | 2007-04-30 | Zenyaku Kogyo Kk | Composto heterocíclico e agente antitumoral contendo o mesmo como igrediente activo |
| US7122665B2 (en) | 2002-10-15 | 2006-10-17 | Synta Pharmaceuticals Corp. | Heterocyclic compounds |
| AU2003275630B2 (en) | 2002-10-25 | 2010-02-18 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compounds and antitumor agent comprising the same as effective component |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| EP2316831B1 (en) | 2002-11-21 | 2013-03-06 | Novartis AG | 2-(morpholin-4-yl)pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer |
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| GB0525081D0 (en) | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| KR20080083188A (ko) | 2006-01-11 | 2008-09-16 | 아스트라제네카 아베 | 모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도 |
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| WO2007127175A2 (en) | 2006-04-26 | 2007-11-08 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| BRPI0710874A2 (pt) | 2006-04-26 | 2012-02-14 | Hoffmann La Roche | compostos de tienopirimidina, processos de produção dos referidos compostos, composições farmacêuticas contendo os mesmos, kit, produto, e usos dos compostos |
| TW200801012A (en) | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| CA2650196A1 (en) | 2006-04-26 | 2007-11-01 | Stewart James Baker | Pyrimidine derivatives as pi3k inhibitors |
| GB0611152D0 (en) | 2006-06-06 | 2006-07-19 | Ucb Sa | Therapeutic agents |
| ES2657635T3 (es) | 2006-08-08 | 2018-03-06 | Chugai Seiyaku Kabushiki Kaisha | Derivado de pirimidina como inhibidor de PI3K y uso del mismo |
| HUE033894T2 (en) | 2006-08-23 | 2018-01-29 | Kudos Pharm Ltd | 2-Methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as MTOR inhibitors |
| EP2057129A1 (en) | 2006-08-24 | 2009-05-13 | AstraZeneca AB | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| AU2007287428B2 (en) | 2006-08-24 | 2011-08-11 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| WO2008032028A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 2 -benzimidazolyl- 6 -morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032091A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidaz0lyl-6-m0rph0lin0-2-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032033A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032072A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032060A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders |
| US20090325954A1 (en) | 2006-09-14 | 2009-12-31 | Sam Butterworth | 2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032089A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032036A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| GB0620818D0 (en) | 2006-10-19 | 2006-11-29 | Ucb Sa | Therapeutic agents |
| MX2009004077A (es) | 2006-10-19 | 2009-05-05 | Signal Pharm Llc | Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas. |
| JP2010510245A (ja) | 2006-11-21 | 2010-04-02 | スミスクライン ビーチャム コーポレーション | 抗ウイルス化合物 |
| EP2114950B1 (en) | 2006-12-07 | 2016-03-09 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| AU2007329352B2 (en) | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US8173647B2 (en) | 2007-02-06 | 2012-05-08 | Gordana Atallah | PI 3-kinase inhibitors and methods of their use |
| US20080234262A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
| US20080233127A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| KR20100016433A (ko) | 2007-04-12 | 2010-02-12 | 에프. 호프만-라 로슈 아게 | 포스파티딜이노시톨-3-키나제의 저해제로서의 피리미딘 유도체 |
| GB0707087D0 (en) | 2007-04-12 | 2007-05-23 | Piramed Ltd | Pharmaceutical compounds |
| EP2146981A1 (en) | 2007-04-12 | 2010-01-27 | F. Hoffmann-Roche AG | Pharmaceutical compounds |
| WO2008152387A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Quinazoline derivatives as pi3 kinase inhibitors |
| US7893060B2 (en) | 2007-06-12 | 2011-02-22 | F. Hoffmann-La Roche Ag | Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase |
| WO2008152394A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Pharmaceutical compounds |
| EA201000092A1 (ru) | 2007-07-09 | 2010-06-30 | Астразенека Аб | Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний |
| TW200908984A (en) | 2007-08-07 | 2009-03-01 | Piramal Life Sciences Ltd | Pyridyl derivatives, their preparation and use |
| EP2205242B1 (en) | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| ES2399774T3 (es) | 2007-09-24 | 2013-04-03 | Genentech, Inc. | Compuestos de tiazolopirimidina inhibidores de PI3K y métodos de uso |
| KR20160116045A (ko) | 2007-10-05 | 2016-10-06 | 베라스템, 인코포레이티드 | 피리미딘 치환된 퓨린 유도체 |
| US20110009403A1 (en) | 2007-10-05 | 2011-01-13 | S*Bio Pte Ltd. | 2-morpholinylpurines as inhibitors of pi3k |
| JP5547637B2 (ja) | 2007-10-05 | 2014-07-16 | インデックス・ファーマシューティカルズ・アクチエボラーグ | 浮腫を治療または軽減するための新規な化合物およびその使用方法 |
| JP2011500702A (ja) | 2007-10-16 | 2011-01-06 | ワイス・エルエルシー | チエノピリミジンおよびピラゾロピリミジン化合物ならびにｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのその使用 |
| JP5348725B2 (ja) | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| WO2009053716A1 (en) | 2007-10-26 | 2009-04-30 | F.Hoffmann-La Roche Ag | Purine derivatives useful as pi3 kinase inhibitors |
| GB0721095D0 (en) | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| WO2009066084A1 (en) | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| US20090149458A1 (en) | 2007-11-27 | 2009-06-11 | Wyeth | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS |
| GB0723747D0 (en) | 2007-12-04 | 2008-12-31 | Ucb Pharma Sa | Therapeutic agents |
| GB0723748D0 (en) | 2007-12-04 | 2008-01-16 | Ucb Pharma Sa | Therapeutic agents |
| WO2009071895A1 (en) | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Fused thiazole and thiophene derivatives as kinase inhibitors |
| WO2009071890A1 (en) | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Tricyclic kinase inhibitors |
| US7820665B2 (en) | 2007-12-19 | 2010-10-26 | Amgen Inc. | Imidazopyridazine inhibitors of PI3 kinase for cancer treatment |
| EA201001017A1 (ru) | 2008-01-15 | 2011-02-28 | ВАЙЕТ ЭлЭлСи | 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы |
| WO2009093981A1 (en) | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| EP2231152B1 (en) | 2008-01-24 | 2014-01-01 | SignalRX Pharmaceuticals, Inc. | Thienopyranones as kinase inhibitors |
| US9029411B2 (en) | 2008-01-25 | 2015-05-12 | Millennium Pharmaceuticals, Inc. | Thiophenes and uses thereof |
| JP2011510071A (ja) | 2008-01-25 | 2011-03-31 | アストラゼネカ アクチボラグ | 鏡像異性的に純粋な（−）２−［１−（７−メチル−２−（モルホリン−４−イル）−４−オキソ−４Ｈ−ピリド［１，２−ａ］ピリミジン−９−イル）エチルアミノ］安息香酸、医学的療法における該物質の使用、および該物質を含む薬学的組成物−０２６ |
| CL2009000241A1 (es) | 2008-02-07 | 2010-09-03 | Chugai Pharmaceutical Co Ltd | Compuestos derivados de 5-(2-morfolin-4-il-7h-pirrolo[2,3-d]pirimidin-4-il)pirimidin-2-ilamina; proceso de preparacion; composicion farmaceutica; y uso de los compuestos para tratar o prevenir una enfermedad proliferativa tal como el cancer. |
| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
-
2009
- 2009-10-12 TW TW098134442A patent/TWI378933B/zh not_active IP Right Cessation
- 2009-10-13 PT PT98205792T patent/PT2336132E/pt unknown
- 2009-10-13 MX MX2011003490A patent/MX2011003490A/es active IP Right Grant
- 2009-10-13 WO PCT/JP2009/067738 patent/WO2010044401A1/ja not_active Ceased
- 2009-10-13 NZ NZ592761A patent/NZ592761A/en not_active IP Right Cessation
- 2009-10-13 KR KR1020117008413A patent/KR101614976B1/ko not_active Expired - Fee Related
- 2009-10-13 ES ES09820579.2T patent/ES2452541T3/es active Active
- 2009-10-13 CA CA2740471A patent/CA2740471C/en not_active Expired - Fee Related
- 2009-10-13 JP JP2009236444A patent/JP5090423B2/ja not_active Expired - Fee Related
- 2009-10-13 CN CN200980151585.4A patent/CN102245607B/zh not_active Expired - Fee Related
- 2009-10-13 DK DK09820579.2T patent/DK2336132T3/da active
- 2009-10-13 MY MYPI2011001420A patent/MY156456A/en unknown
- 2009-10-13 BR BRPI0920199A patent/BRPI0920199A2/pt not_active IP Right Cessation
- 2009-10-13 AU AU2009304789A patent/AU2009304789B2/en not_active Ceased
- 2009-10-13 PL PL09820579T patent/PL2336132T3/pl unknown
- 2009-10-13 RU RU2011119525/04A patent/RU2490269C2/ru not_active IP Right Cessation
- 2009-10-13 EP EP09820579.2A patent/EP2336132B1/en not_active Not-in-force
- 2009-10-14 US US12/579,175 patent/US8097622B2/en not_active Expired - Fee Related
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2011
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- 2011-04-12 IL IL212278A patent/IL212278A/en not_active IP Right Cessation
- 2011-05-09 CO CO11056552A patent/CO6362009A2/es active IP Right Grant
- 2011-11-30 US US13/308,239 patent/US8309546B2/en not_active Expired - Fee Related
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