CO6362009A2 - Derivados de morfolinopurina - Google Patents
Derivados de morfolinopurinaInfo
- Publication number
- CO6362009A2 CO6362009A2 CO11056552A CO11056552A CO6362009A2 CO 6362009 A2 CO6362009 A2 CO 6362009A2 CO 11056552 A CO11056552 A CO 11056552A CO 11056552 A CO11056552 A CO 11056552A CO 6362009 A2 CO6362009 A2 CO 6362009A2
- Authority
- CO
- Colombia
- Prior art keywords
- morfolinopurine
- derivatives
- mtor
- formula
- pi3k
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe un compuesto novedoso que puede inhibir fosfatidilinositol 3-cinasa (PI3K) y/o el objetivo de la rapamicina en mamíferos (mTOR) y tiene una actividad antitumor. Se describe específicamente un compuesto que puede inhibir PI3K y/o mTOR, tiene actividad antitumor y es representado por la fórmula (1) que tiene varios sustituyentes:en la fórmula (1), R1, R2, R3, R4, Ra, Rb, Rc y X son como se define en la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008264797 | 2008-10-14 | ||
JP2009121690 | 2009-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6362009A2 true CO6362009A2 (es) | 2012-01-20 |
Family
ID=42106564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11056552A CO6362009A2 (es) | 2008-10-14 | 2011-05-09 | Derivados de morfolinopurina |
Country Status (22)
Country | Link |
---|---|
US (2) | US8097622B2 (es) |
EP (1) | EP2336132B1 (es) |
JP (1) | JP5090423B2 (es) |
KR (1) | KR101614976B1 (es) |
CN (1) | CN102245607B (es) |
AU (1) | AU2009304789B2 (es) |
BR (1) | BRPI0920199A2 (es) |
CA (1) | CA2740471C (es) |
CO (1) | CO6362009A2 (es) |
DK (1) | DK2336132T3 (es) |
ES (1) | ES2452541T3 (es) |
HK (1) | HK1158189A1 (es) |
IL (1) | IL212278A (es) |
MX (1) | MX2011003490A (es) |
MY (1) | MY156456A (es) |
NZ (1) | NZ592761A (es) |
PL (1) | PL2336132T3 (es) |
PT (1) | PT2336132E (es) |
RU (1) | RU2490269C2 (es) |
TW (1) | TWI378933B (es) |
WO (1) | WO2010044401A1 (es) |
ZA (1) | ZA201102449B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102105474B (zh) * | 2008-05-30 | 2014-01-08 | 健泰科生物技术公司 | 嘌呤pi3k抑制剂化合物及使用方法 |
TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
KR101469334B1 (ko) * | 2009-11-12 | 2014-12-04 | 에프. 호프만-라 로슈 아게 | N-9-치환된 퓨린 화합물, 조성물 및 사용 방법 |
CN102260263A (zh) * | 2010-05-26 | 2011-11-30 | 四川大学 | 一类二苯胺基嘌呤衍生物及制备方法和医药用途 |
EP2593455B1 (en) | 2010-07-14 | 2015-03-18 | F.Hoffmann-La Roche Ag | Purine compounds selective for i3 p110 delta, and methods of use |
TWI441824B (zh) | 2010-12-16 | 2014-06-21 | Hoffmann La Roche | 三環pi3k抑制劑化合物及其使用方法 |
PL2771342T3 (pl) | 2011-10-28 | 2016-11-30 | Nowe pochodne puryny i ich zastosowanie w leczeniu chorób | |
CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
WO2014185368A1 (ja) * | 2013-05-13 | 2014-11-20 | 第一三共株式会社 | 5-{8-[(3r)-4-アセチル-3-メチルピペラジン-1-イル]-6-モルホリン-4-イル-9-(2,2,2-トリフルオロエチル)-9h-プリン-2-イル}ピリミジン-2-アミン、およびその薬理上許容される塩の新規な結晶、およびその製造方法 |
TW201520215A (zh) * | 2013-05-13 | 2015-06-01 | Daiichi Sankyo Co Ltd | N-□啉基嘌呤衍生物之製造方法 |
WO2015013579A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
ES2721302T3 (es) * | 2013-10-04 | 2019-07-30 | Univ Basel | Inhibidores de PI3k y mTOR conformacionalmente restringidos |
LT3277682T (lt) | 2015-03-30 | 2019-06-25 | Daiichi Sankyo Company, Limited | 6-morfolinil-2-pirazolil-9h-purino dariniai ir jų panaudojimas kaip pi3k inhibitorių |
US10765681B2 (en) | 2016-02-05 | 2020-09-08 | Academia Sinica | Purine compounds possessing anticancer activity |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
CN110036109A (zh) | 2016-12-02 | 2019-07-19 | 第一三共株式会社 | 新颖的内-β-N-乙酰基氨基葡糖苷酶 |
EP3360865A1 (en) * | 2017-02-13 | 2018-08-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272 |
JP7479292B2 (ja) | 2018-11-29 | 2024-05-08 | 第一三共株式会社 | 組み合わせ医薬として用いられるezh1/2二重阻害剤を含有する医薬組成物 |
CN113368114B (zh) * | 2020-03-10 | 2022-04-22 | 四川大学 | 一种吗啉嘧啶类化合物的抗肿瘤应用 |
BR112023018799A2 (pt) * | 2021-03-17 | 2023-12-12 | Medivir Ab | Derivados de purina como agentes anticâncer |
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2009
- 2009-10-12 TW TW098134442A patent/TWI378933B/zh not_active IP Right Cessation
- 2009-10-13 DK DK09820579.2T patent/DK2336132T3/da active
- 2009-10-13 JP JP2009236444A patent/JP5090423B2/ja not_active Expired - Fee Related
- 2009-10-13 RU RU2011119525/04A patent/RU2490269C2/ru not_active IP Right Cessation
- 2009-10-13 AU AU2009304789A patent/AU2009304789B2/en not_active Ceased
- 2009-10-13 ES ES09820579.2T patent/ES2452541T3/es active Active
- 2009-10-13 WO PCT/JP2009/067738 patent/WO2010044401A1/ja active Application Filing
- 2009-10-13 NZ NZ592761A patent/NZ592761A/en not_active IP Right Cessation
- 2009-10-13 EP EP09820579.2A patent/EP2336132B1/en not_active Not-in-force
- 2009-10-13 MY MYPI2011001420A patent/MY156456A/en unknown
- 2009-10-13 KR KR1020117008413A patent/KR101614976B1/ko not_active IP Right Cessation
- 2009-10-13 CN CN200980151585.4A patent/CN102245607B/zh not_active Expired - Fee Related
- 2009-10-13 PT PT98205792T patent/PT2336132E/pt unknown
- 2009-10-13 CA CA2740471A patent/CA2740471C/en not_active Expired - Fee Related
- 2009-10-13 BR BRPI0920199A patent/BRPI0920199A2/pt not_active IP Right Cessation
- 2009-10-13 PL PL09820579T patent/PL2336132T3/pl unknown
- 2009-10-13 MX MX2011003490A patent/MX2011003490A/es active IP Right Grant
- 2009-10-14 US US12/579,175 patent/US8097622B2/en not_active Expired - Fee Related
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2011
- 2011-04-01 ZA ZA2011/02449A patent/ZA201102449B/en unknown
- 2011-04-12 IL IL212278A patent/IL212278A/en not_active IP Right Cessation
- 2011-05-09 CO CO11056552A patent/CO6362009A2/es active IP Right Grant
- 2011-11-18 HK HK11112477.4A patent/HK1158189A1/xx not_active IP Right Cessation
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