CO6362009A2 - Derivados de morfolinopurina - Google Patents

Derivados de morfolinopurina

Info

Publication number
CO6362009A2
CO6362009A2 CO11056552A CO11056552A CO6362009A2 CO 6362009 A2 CO6362009 A2 CO 6362009A2 CO 11056552 A CO11056552 A CO 11056552A CO 11056552 A CO11056552 A CO 11056552A CO 6362009 A2 CO6362009 A2 CO 6362009A2
Authority
CO
Colombia
Prior art keywords
morfolinopurine
derivatives
mtor
formula
pi3k
Prior art date
Application number
CO11056552A
Other languages
English (en)
Spanish (es)
Inventor
Kiyoshi Nakayama
Kazuyuki Sugita
Takashi Odagiri
Masanori Saitou
Yuichi Tominaga
Masaki Setoguchi
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CO6362009A2 publication Critical patent/CO6362009A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CO11056552A 2008-10-14 2011-05-09 Derivados de morfolinopurina CO6362009A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008264797 2008-10-14
JP2009121690 2009-05-20

Publications (1)

Publication Number Publication Date
CO6362009A2 true CO6362009A2 (es) 2012-01-20

Family

ID=42106564

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11056552A CO6362009A2 (es) 2008-10-14 2011-05-09 Derivados de morfolinopurina

Country Status (21)

Country Link
US (2) US8097622B2 (enExample)
EP (1) EP2336132B1 (enExample)
JP (1) JP5090423B2 (enExample)
KR (1) KR101614976B1 (enExample)
CN (1) CN102245607B (enExample)
AU (1) AU2009304789B2 (enExample)
BR (1) BRPI0920199A2 (enExample)
CA (1) CA2740471C (enExample)
CO (1) CO6362009A2 (enExample)
DK (1) DK2336132T3 (enExample)
ES (1) ES2452541T3 (enExample)
IL (1) IL212278A (enExample)
MX (1) MX2011003490A (enExample)
MY (1) MY156456A (enExample)
NZ (1) NZ592761A (enExample)
PL (1) PL2336132T3 (enExample)
PT (1) PT2336132E (enExample)
RU (1) RU2490269C2 (enExample)
TW (1) TWI378933B (enExample)
WO (1) WO2010044401A1 (enExample)
ZA (1) ZA201102449B (enExample)

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JP2011521968A (ja) * 2008-05-30 2011-07-28 ジェネンテック， インコーポレイテッド プリンｐｉ３ｋ阻害剤化合物および使用方法
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BR112012011188A2 (pt) * 2009-11-12 2021-06-29 F.Hoffmann - La Roche Ag ''composto,composição farmacêutica e uso de um composto"
CN102260263A (zh) * 2010-05-26 2011-11-30 四川大学 一类二苯胺基嘌呤衍生物及制备方法和医药用途
EP2593455B1 (en) 2010-07-14 2015-03-18 F.Hoffmann-La Roche Ag Purine compounds selective for i3 p110 delta, and methods of use
SG10201510347QA (en) 2010-12-16 2016-01-28 Hoffmann La Roche Tricyclic pi3k inhibitor compounds and methods of use
US9334271B2 (en) 2011-10-28 2016-05-10 Novarits Ag Purine derivatives and their use in the treatment of disease
CN103012284A (zh) * 2012-12-26 2013-04-03 无锡捷化医药科技有限公司 一种2-氨基-5-溴嘧啶类化合物的制备方法
WO2014185368A1 (ja) * 2013-05-13 2014-11-20 第一三共株式会社 ５－｛８－［（３ｒ）－４－アセチル－３－メチルピペラジン－１－イル］－６－モルホリン－４－イル－９－（２，２，２－トリフルオロエチル）－９ｈ－プリン－２－イル｝ピリミジン－２－アミン、およびその薬理上許容される塩の新規な結晶、およびその製造方法
WO2014185367A1 (ja) * 2013-05-13 2014-11-20 第一三共株式会社 モルホリノプリン誘導体の製造方法
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US10765681B2 (en) 2016-02-05 2020-09-08 Academia Sinica Purine compounds possessing anticancer activity
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US11208442B2 (en) 2016-12-02 2021-12-28 Daiichi Sankyo Company, Limited Endo-beta-N-acetylglucosaminidase
EP3360865A1 (en) 2017-02-13 2018-08-15 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272
TWI837231B (zh) 2018-11-29 2024-04-01 日商第一三共股份有限公司 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途
CN113368114B (zh) * 2020-03-10 2022-04-22 四川大学 一种吗啉嘧啶类化合物的抗肿瘤应用
JP2024511996A (ja) * 2021-03-17 2024-03-18 タンゴ セラピューティクス， インコーポレイテッド 抗がん剤としてのプリン誘導体

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Also Published As

Publication number Publication date
IL212278A0 (en) 2011-06-30
EP2336132B1 (en) 2014-01-01
CA2740471A1 (en) 2010-04-22
US20120071476A1 (en) 2012-03-22
US20100130492A1 (en) 2010-05-27
US8309546B2 (en) 2012-11-13
WO2010044401A1 (ja) 2010-04-22
NZ592761A (en) 2012-05-25
ZA201102449B (en) 2011-12-28
AU2009304789B2 (en) 2012-04-05
US8097622B2 (en) 2012-01-17
KR101614976B1 (ko) 2016-04-22
CA2740471C (en) 2013-09-17
KR20110067038A (ko) 2011-06-20
HK1158189A1 (en) 2012-07-13
PL2336132T3 (pl) 2014-06-30
CN102245607B (zh) 2014-07-02
JP5090423B2 (ja) 2012-12-05
CN102245607A (zh) 2011-11-16
BRPI0920199A2 (pt) 2019-09-24
MX2011003490A (es) 2011-04-21
RU2490269C2 (ru) 2013-08-20
EP2336132A1 (en) 2011-06-22
TWI378933B (en) 2012-12-11
PT2336132E (pt) 2014-04-02
EP2336132A4 (en) 2012-03-21
AU2009304789A1 (en) 2010-04-22
IL212278A (en) 2016-07-31
RU2011119525A (ru) 2012-11-27
MY156456A (en) 2016-02-26
JP2011001339A (ja) 2011-01-06
DK2336132T3 (da) 2014-04-07
TW201018690A (en) 2010-05-16
ES2452541T3 (es) 2014-04-01

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