CN101784545B - 用作raf激酶抑制剂的嘧啶衍生物 - Google Patents
用作raf激酶抑制剂的嘧啶衍生物 Download PDFInfo
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- CN101784545B CN101784545B CN200880022788.9A CN200880022788A CN101784545B CN 101784545 B CN101784545 B CN 101784545B CN 200880022788 A CN200880022788 A CN 200880022788A CN 101784545 B CN101784545 B CN 101784545B
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- 0 CC(C1CC(C(NC2CC*(*)CC2)=O)=CCCC1)N(*)C(c1ncnc(*)c1*)=O Chemical compound CC(C1CC(C(NC2CC*(*)CC2)=O)=CCCC1)N(*)C(c1ncnc(*)c1*)=O 0.000 description 11
- NXFWIRWDNSPGLA-UHFFFAOYSA-N C=Nc1cc(C(O)=O)cc(C(F)(F)F)c1 Chemical compound C=Nc1cc(C(O)=O)cc(C(F)(F)F)c1 NXFWIRWDNSPGLA-UHFFFAOYSA-N 0.000 description 1
- OHRSMOABLOCNKF-UHFFFAOYSA-N CC(C(CC1)CCC1C(NC1CCCCC1)=O)N Chemical compound CC(C(CC1)CCC1C(NC1CCCCC1)=O)N OHRSMOABLOCNKF-UHFFFAOYSA-N 0.000 description 1
- LWINVKDSGJDBQF-UHFFFAOYSA-N CC(C(CCC1)CC1C(NC1CCCCC1)=O)N Chemical compound CC(C(CCC1)CC1C(NC1CCCCC1)=O)N LWINVKDSGJDBQF-UHFFFAOYSA-N 0.000 description 1
- VOXCVLUIHREXGI-UHFFFAOYSA-N CC(CS1=CC=C1C(Nc1cc(C(F)(F)F)cc(C(N(C)C)=O)c1)=O)N Chemical compound CC(CS1=CC=C1C(Nc1cc(C(F)(F)F)cc(C(N(C)C)=O)c1)=O)N VOXCVLUIHREXGI-UHFFFAOYSA-N 0.000 description 1
- RNAXPKYALUQPOD-UHFFFAOYSA-N CC(c1ccc(Nc(cc2C(F)(F)F)ccc2Cl)nc1)N Chemical compound CC(c1ccc(Nc(cc2C(F)(F)F)ccc2Cl)nc1)N RNAXPKYALUQPOD-UHFFFAOYSA-N 0.000 description 1
- PEYBQISICYJZBE-UHFFFAOYSA-N CN(C)C(c1cc(C(F)(F)F)cc(N)c1)=O Chemical compound CN(C)C(c1cc(C(F)(F)F)cc(N)c1)=O PEYBQISICYJZBE-UHFFFAOYSA-N 0.000 description 1
- IHCUJWDFSMLODH-IUDNXUCKSA-N C[C@H](C(CC1)CCC1C(NCC1CCCCCC1)=O)N Chemical compound C[C@H](C(CC1)CCC1C(NCC1CCCCCC1)=O)N IHCUJWDFSMLODH-IUDNXUCKSA-N 0.000 description 1
- HAIIFVMMOJJTNH-ZCFIWIBFSA-N C[C@H](c1cc(-c2nc(cc(C(F)(F)F)cc3)c3[nH]2)n[o]1)N Chemical compound C[C@H](c1cc(-c2nc(cc(C(F)(F)F)cc3)c3[nH]2)n[o]1)N HAIIFVMMOJJTNH-ZCFIWIBFSA-N 0.000 description 1
- WUMTUMNNMDPCQY-SECBINFHSA-N C[C@H](c1cc(-c2nc(cc(C(F)(F)F)cc3)c3[nH]2)n[o]1)NC(OC(C)(C)C)=O Chemical compound C[C@H](c1cc(-c2nc(cc(C(F)(F)F)cc3)c3[nH]2)n[o]1)NC(OC(C)(C)C)=O WUMTUMNNMDPCQY-SECBINFHSA-N 0.000 description 1
- QHPHGGWCQRZOIQ-ZCFIWIBFSA-N C[C@H](c1cc(C(O)=O)n[o]1)NC(OC(C)(C)C)=O Chemical compound C[C@H](c1cc(C(O)=O)n[o]1)NC(OC(C)(C)C)=O QHPHGGWCQRZOIQ-ZCFIWIBFSA-N 0.000 description 1
- IUTRXWNRCBITFD-UHFFFAOYSA-N O=C(C1CCCCC1)NC1CCCCC1 Chemical compound O=C(C1CCCCC1)NC1CCCCC1 IUTRXWNRCBITFD-UHFFFAOYSA-N 0.000 description 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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| CN201611139456.1A CN106957314B (zh) | 2007-06-29 | 2008-06-30 | 用作raf激酶抑制剂的嘧啶衍生物 |
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| CN201611139456.1A Division CN106957314B (zh) | 2007-06-29 | 2008-06-30 | 用作raf激酶抑制剂的嘧啶衍生物 |
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| CN201410466320.6A Active CN104370828B (zh) | 2007-06-29 | 2008-06-30 | 用作raf激酶抑制剂的嘧啶衍生物 |
| CN201611139456.1A Active CN106957314B (zh) | 2007-06-29 | 2008-06-30 | 用作raf激酶抑制剂的嘧啶衍生物 |
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| CN201611139456.1A Active CN106957314B (zh) | 2007-06-29 | 2008-06-30 | 用作raf激酶抑制剂的嘧啶衍生物 |
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