CN101679408B - 作为fgfr抑制剂的双环杂环化合物 - Google Patents

作为fgfr抑制剂的双环杂环化合物 Download PDF

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Publication number
CN101679408B
CN101679408B CN200780047672.6A CN200780047672A CN101679408B CN 101679408 B CN101679408 B CN 101679408B CN 200780047672 A CN200780047672 A CN 200780047672A CN 101679408 B CN101679408 B CN 101679408B
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group
compound
formula
phenyl
alkyl
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Expired - Fee Related
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CN200780047672.6A
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CN101679408A (zh
Inventor
瓦雷奥·伯蒂尼
基伯特·俄白·苯菘
欧文·卡拉格汉
马日拉·格拉斯阿·卡尔
莫尔·斯图阿特·空各日乌
阿德热安·利安姆·吉尔
莎乐特·马里·各热夫斯-琼斯
安竺·马丁
克斯托弗·威廉·姆热
娆吉狄浦·卡尔·尼基价
麦克·阿里斯塔·欧布赖恩
安竺·俳克
果登·萨克斯提
里查德·大为·忒勒
爱玛·魏克-斯塔夫
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GB0625826A external-priority patent/GB0625826D0/en
Priority claimed from GB0720000A external-priority patent/GB0720000D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
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  • Endocrinology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
CN200780047672.6A 2006-12-22 2007-12-21 作为fgfr抑制剂的双环杂环化合物 Expired - Fee Related CN101679408B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US87154306P 2006-12-22 2006-12-22
US60/871,543 2006-12-22
GB0625826.3 2006-12-22
GB0625826A GB0625826D0 (en) 2006-12-22 2006-12-22 New compounds
US97958707P 2007-10-12 2007-10-12
US60/979,587 2007-10-12
GB0720000.9 2007-10-12
GB0720000A GB0720000D0 (en) 2007-10-12 2007-10-12 New compounds
US98103907P 2007-10-18 2007-10-18
US60/981,039 2007-10-18
PCT/GB2007/004934 WO2008078091A1 (en) 2006-12-22 2007-12-21 Bicyclic heterocyclic compounds as fgfr inhibitors

Publications (2)

Publication Number Publication Date
CN101679408A CN101679408A (zh) 2010-03-24
CN101679408B true CN101679408B (zh) 2016-04-27

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CN200780047672.6A Expired - Fee Related CN101679408B (zh) 2006-12-22 2007-12-21 作为fgfr抑制剂的双环杂环化合物

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Country Link
US (1) US8895745B2 (enExample)
EP (1) EP2114941B1 (enExample)
JP (1) JP5442448B2 (enExample)
CN (1) CN101679408B (enExample)
AR (1) AR064491A1 (enExample)
AU (1) AU2007337886C1 (enExample)
CA (1) CA2672172C (enExample)
HR (1) HRP20150642T1 (enExample)
MX (1) MX2009006706A (enExample)
NO (1) NO343370B1 (enExample)
WO (1) WO2008078091A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

Families Citing this family (158)

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US8895745B2 (en) 2006-12-22 2014-11-25 Astex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
CA2672213C (en) 2006-12-22 2016-02-16 Astex Therapeutics Limited Bicyclic amine derivatives as protein tyrosine kinase inhibitors
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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MX2010005110A (es) 2007-11-14 2010-09-09 Ortho Mcneil Janssen Pharm Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2.
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JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
CA2744138C (en) * 2008-11-28 2015-08-11 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MX2011009796A (es) * 2009-03-20 2011-12-14 Amgen Inc Inhibidores de la cinasa pi3.
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
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MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
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UA111579C2 (uk) * 2009-08-17 2016-05-25 Інтеллікіне Ллк ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
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