CN101679405A - 作为葡萄糖激酶活性剂的2-氨基吡啶类似物 - Google Patents

作为葡萄糖激酶活性剂的2-氨基吡啶类似物 Download PDF

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Publication number
CN101679405A
CN101679405A CN200880017007A CN200880017007A CN101679405A CN 101679405 A CN101679405 A CN 101679405A CN 200880017007 A CN200880017007 A CN 200880017007A CN 200880017007 A CN200880017007 A CN 200880017007A CN 101679405 A CN101679405 A CN 101679405A
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alkyl
compound
formula
pyridin
mmol
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CN200880017007A
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Chinese (zh)
Inventor
托马斯·D·艾彻
史蒂文·A·博伊德
马克·J·齐卡雷利
凯文·R·康德罗斯基
罗纳德·J·欣克林
阿杰伊·辛格
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Array Biopharma Inc
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Array Biopharma Inc
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Priority claimed from PCT/US2007/007444 external-priority patent/WO2007117381A2/en
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Publication of CN101679405A publication Critical patent/CN101679405A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Obesity (AREA)
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  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
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  • Communicable Diseases (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
CN200880017007A 2007-03-23 2008-03-19 作为葡萄糖激酶活性剂的2-氨基吡啶类似物 Pending CN101679405A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91971907P 2007-03-23 2007-03-23
PCT/US2007/007444 WO2007117381A2 (en) 2006-03-24 2007-03-23 2 -aminopyridine analogs as glucokinase activators
US60/919,719 2007-03-23
USPCT/US2007/007444 2007-03-23
US97426007P 2007-09-21 2007-09-21
US60/974,260 2007-09-21
PCT/US2008/057543 WO2008118718A2 (en) 2007-03-23 2008-03-19 2-aminopyridine analogs as glucokinase activators

Publications (1)

Publication Number Publication Date
CN101679405A true CN101679405A (zh) 2010-03-24

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CN200880017007A Pending CN101679405A (zh) 2007-03-23 2008-03-19 作为葡萄糖激酶活性剂的2-氨基吡啶类似物

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Country Link
US (1) US8362037B2 (https=)
EP (1) EP2173745A2 (https=)
JP (1) JP5450108B2 (https=)
CN (1) CN101679405A (https=)
CA (1) CA2681695A1 (https=)
TW (1) TW200843765A (https=)
WO (1) WO2008118718A2 (https=)

Cited By (1)

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CN106349159A (zh) * 2016-08-29 2017-01-25 山东省联合农药工业有限公司 一种3‑氯‑2‑氰基‑5‑三氟甲基吡啶的制备方法

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WO2008091770A1 (en) * 2007-01-24 2008-07-31 Array Biopharma Inc. 2-aminopyridine derivatives as glucokinase activators
EP2573087A1 (en) 2007-09-21 2013-03-27 Array Biopharma, Inc. Pyridin-2-yl-amino-1,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
BRPI0818658A2 (pt) 2007-10-09 2015-04-14 Merck Patent Ges Mit Beschränkter Haftung Derivados de piridina úteis como ativadores de glicoquinase
CN101970432B (zh) * 2008-01-25 2014-05-28 杜邦公司 杀真菌杂环化合物
AR077821A1 (es) * 2009-08-11 2011-09-28 Sanofi Aventis Us Llc Procedimiento para preparar hidrocloruro de 4-metil-3-tienilamina
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CN102959076B (zh) 2010-03-31 2015-09-16 斯克里普斯研究所 重编程细胞
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
JPWO2012121314A1 (ja) 2011-03-09 2014-07-17 第一三共株式会社 ジピリジルアミン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2877026A1 (en) 2012-05-18 2013-11-21 Amgen Inc. Method for the preparation of thiadiazoles
ES2619708T3 (es) 2013-03-13 2017-06-26 VIIV Healthcare UK (No.5) Limited Inhibidores de la replicación del virus de inmunodeficiencia humana
WO2014164467A1 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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CN107286087B (zh) * 2017-04-16 2020-01-07 内蒙古佳瑞米精细化工有限公司 一种2-氰基-3-氯-5-三氟甲基吡啶的合成方法
MX2020002762A (es) 2017-09-15 2020-09-17 Azevan Pharmaceuticals Inc Composiciones y métodos para tratar una lesión cerebral.
SG11202003879RA (en) 2017-10-30 2020-05-28 Neuropore Therapies Inc Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
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EP4077276A1 (en) 2019-12-19 2022-10-26 Curia Spain S.A.U. Process and intermediates for the preparation of upadacitinib
TW202146393A (zh) 2020-03-03 2021-12-16 美商皮克醫療公司 Eif4e抑制劑及其用途
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
CA3229560A1 (en) 2021-08-25 2023-03-02 Christopher L. Vandeusen Eif4e inhibitors and uses thereof
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US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349159A (zh) * 2016-08-29 2017-01-25 山东省联合农药工业有限公司 一种3‑氯‑2‑氰基‑5‑三氟甲基吡啶的制备方法
CN106349159B (zh) * 2016-08-29 2019-03-22 山东省联合农药工业有限公司 一种3-氯-2-氰基-5-三氟甲基吡啶的制备方法

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JP5450108B2 (ja) 2014-03-26
CA2681695A1 (en) 2008-10-02
US8362037B2 (en) 2013-01-29
JP2010527911A (ja) 2010-08-19
EP2173745A2 (en) 2010-04-14
US20100105659A1 (en) 2010-04-29
WO2008118718A2 (en) 2008-10-02
WO2008118718A3 (en) 2008-11-13
TW200843765A (en) 2008-11-16

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