CN1016782B - 制备1-羟乙基-2-甲基-5-硝基咪唑的方法 - Google Patents

制备1-羟乙基-2-甲基-5-硝基咪唑的方法

Info

Publication number
CN1016782B
CN1016782B CN89100172A CN89100172A CN1016782B CN 1016782 B CN1016782 B CN 1016782B CN 89100172 A CN89100172 A CN 89100172A CN 89100172 A CN89100172 A CN 89100172A CN 1016782 B CN1016782 B CN 1016782B
Authority
CN
China
Prior art keywords
methyl
nitroimidazole
acetyl
ester
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN89100172A
Other languages
English (en)
Chinese (zh)
Other versions
CN1035111A (zh
Inventor
马索尼奥·维维安尼
姆赫瑟·米歇尔
布方·阿尔贝特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of CN1035111A publication Critical patent/CN1035111A/zh
Publication of CN1016782B publication Critical patent/CN1016782B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/24—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN89100172A 1988-01-15 1989-01-12 制备1-羟乙基-2-甲基-5-硝基咪唑的方法 Expired CN1016782B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8800416A FR2625996B1 (fr) 1988-01-15 1988-01-15 Procede de preparation d'agents d'hydroxyalkylation, les nouveaux agents ainsi obtenus et leur emploi
FR8800416 1988-01-15

Publications (2)

Publication Number Publication Date
CN1035111A CN1035111A (zh) 1989-08-30
CN1016782B true CN1016782B (zh) 1992-05-27

Family

ID=9362337

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89100172A Expired CN1016782B (zh) 1988-01-15 1989-01-12 制备1-羟乙基-2-甲基-5-硝基咪唑的方法

Country Status (22)

Country Link
US (2) US4925950A (enExample)
EP (1) EP0324692B1 (enExample)
JP (1) JPH02766A (enExample)
KR (1) KR890011833A (enExample)
CN (1) CN1016782B (enExample)
AT (1) ATE82747T1 (enExample)
AU (1) AU618776B2 (enExample)
CA (1) CA1310327C (enExample)
DE (1) DE68903570T2 (enExample)
DK (1) DK14189A (enExample)
ES (1) ES2046496T3 (enExample)
FI (1) FI890187L (enExample)
FR (1) FR2625996B1 (enExample)
GR (1) GR3006371T3 (enExample)
HU (1) HU201908B (enExample)
IE (1) IE890092L (enExample)
MX (1) MX14537A (enExample)
NO (1) NO890158L (enExample)
PT (1) PT89444B (enExample)
SU (1) SU1657058A3 (enExample)
YU (1) YU7389A (enExample)
ZA (1) ZA89308B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN214095A0 (en) 1995-04-03 1995-04-27 Australian Water Technologies Pty Ltd Method for detecting microorganisms using flow cytometry
US6764983B1 (en) * 2001-06-29 2004-07-20 Iowa State University Research Foundation Antioxidant compositions and industrial fluids containing same
EP2067770B1 (en) * 2006-09-12 2017-04-12 Wako Pure Chemical Industries, Ltd. Process for production of sulfonic acid ester
AU2015311674B2 (en) 2014-09-05 2018-03-08 Evofem Biosciences, Inc. Secnidazole for use in the treatment of bacterial vaginosis
US11253501B2 (en) 2015-06-01 2022-02-22 Lupin Inc. Secnidazole formulations and use in treating bacterial vaginosis
CN111499508B (zh) * 2020-05-06 2022-09-02 山东国邦药业有限公司 一种环丙甲酸甲酯的制备方法
US12280037B2 (en) 2020-09-22 2025-04-22 Evofem Biosciences, Inc. Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4950440A (en) * 1987-09-14 1990-08-21 Colgate-Palmolive Company Process for the manufacture of high fatty acid monoglyceride monosulfate detergents

Also Published As

Publication number Publication date
CA1310327C (fr) 1992-11-17
FI890187A0 (fi) 1989-01-13
FI890187A7 (fi) 1989-07-16
FR2625996A1 (fr) 1989-07-21
DK14189A (da) 1989-07-16
NO890158L (no) 1989-07-17
JPH02766A (ja) 1990-01-05
KR890011833A (ko) 1989-08-22
US5023361A (en) 1991-06-11
ES2046496T3 (es) 1994-02-01
FI890187L (fi) 1989-07-16
FR2625996B1 (fr) 1990-06-08
US4925950A (en) 1990-05-15
EP0324692B1 (fr) 1992-11-25
EP0324692A1 (fr) 1989-07-19
HU201908B (en) 1991-01-28
SU1657058A3 (ru) 1991-06-15
AU2845489A (en) 1989-07-20
AU618776B2 (en) 1992-01-09
CN1035111A (zh) 1989-08-30
NO890158D0 (no) 1989-01-13
ZA89308B (en) 1989-10-25
YU7389A (en) 1990-12-31
MX14537A (es) 1993-10-01
DK14189D0 (da) 1989-01-13
GR3006371T3 (enExample) 1993-06-21
IE890092L (en) 1989-07-15
PT89444B (pt) 1993-09-30
ATE82747T1 (de) 1992-12-15
DE68903570T2 (de) 1993-05-06
PT89444A (pt) 1990-02-08
DE68903570D1 (de) 1993-01-07
HUT49326A (en) 1989-09-28

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