CN101557830A - 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 - Google Patents
具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 Download PDFInfo
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- CN101557830A CN101557830A CNA2007800463016A CN200780046301A CN101557830A CN 101557830 A CN101557830 A CN 101557830A CN A2007800463016 A CNA2007800463016 A CN A2007800463016A CN 200780046301 A CN200780046301 A CN 200780046301A CN 101557830 A CN101557830 A CN 101557830A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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- Enzymes And Modification Thereof (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610304880.0A CN105838699A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87521706P | 2006-12-15 | 2006-12-15 | |
US60/875,217 | 2006-12-15 | ||
PCT/US2007/087553 WO2008074032A1 (en) | 2006-12-15 | 2007-12-14 | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310698649.0A Division CN103804489A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
CN201610304880.0A Division CN105838699A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101557830A true CN101557830A (zh) | 2009-10-14 |
CN101557830B CN101557830B (zh) | 2016-06-08 |
Family
ID=39119264
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310698649.0A Pending CN103804489A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
CN201610304880.0A Pending CN105838699A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
CN200780046301.6A Active CN101557830B (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310698649.0A Pending CN103804489A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
CN201610304880.0A Pending CN105838699A (zh) | 2006-12-15 | 2007-12-14 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
Country Status (13)
Country | Link |
---|---|
US (4) | US8637007B2 (zh) |
EP (3) | EP2101821B1 (zh) |
JP (4) | JP5876208B2 (zh) |
CN (3) | CN103804489A (zh) |
AU (1) | AU2007333049B2 (zh) |
BR (1) | BRPI0720282B8 (zh) |
CA (1) | CA2670618C (zh) |
DK (1) | DK2101821T3 (zh) |
ES (2) | ES2521490T3 (zh) |
HK (1) | HK1198172A1 (zh) |
PL (1) | PL2101821T3 (zh) |
PT (1) | PT2101821E (zh) |
WO (1) | WO2008074032A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106029106A (zh) * | 2014-02-12 | 2016-10-12 | 诺和诺德保健股份有限公司 | 凝血因子ix缀合物 |
CN106164097A (zh) * | 2014-04-11 | 2016-11-23 | 杰特有限公司 | 用于预防和治疗出血的半衰期延长的因子fviia以及为此的给药方案 |
CN109620963A (zh) * | 2012-05-16 | 2019-04-16 | 百深有限责任公司 | 用于肟键联的亲核性催化剂 |
Families Citing this family (30)
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US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
US7683158B2 (en) | 2006-03-31 | 2010-03-23 | Baxter International Inc. | Pegylated factor VIII |
US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
EP2101821B1 (en) * | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
JP6050927B2 (ja) * | 2007-04-26 | 2016-12-21 | シーエヌジェイ ホールディングス,インコーポレイテッド | 高シアル酸含量を有する組換えビタミンk依存性タンパク質およびその調製方法 |
AR067627A1 (es) | 2007-06-26 | 2009-10-21 | Baxter Int | Enlazador fmoc polimerico hidrolizable. procedimiento de preparacion |
PT2349342T (pt) * | 2008-10-17 | 2018-10-26 | Baxalta Inc | Factores sanguíneos modificados que compreendem um baixo grau de polímero solúvel na água |
WO2010102886A1 (en) | 2009-02-19 | 2010-09-16 | Novo Nordisk A/S | Modification of factor viii |
NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
SG10201401194VA (en) | 2009-07-27 | 2014-07-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
EP2459224B1 (en) | 2009-07-27 | 2016-06-01 | Baxalta GmbH | Blood coagulation protein conjugates |
PL2499165T3 (pl) | 2009-11-13 | 2017-04-28 | Grifols Therapeutics Inc. | Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane |
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GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
KR102269494B1 (ko) | 2010-07-30 | 2021-06-25 | 박스알타 인코퍼레이티드 | 옥심 결합용 친핵성 촉매 |
NZ612320A (en) | 2010-12-22 | 2015-06-26 | Baxter Healthcare Sa | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
IN2014CN02448A (zh) | 2011-09-23 | 2015-06-19 | Novo Nordisk As | |
EA033469B1 (ru) | 2012-04-16 | 2019-10-31 | Cantab Biopharmaceuticals Patents Ltd | Подкожное введение конъюгатов факторов крови с полиэтиленгликолем |
CN104661685A (zh) | 2012-10-15 | 2015-05-27 | 诺和诺德保健Ag(股份有限公司) | 因子vii缀合物 |
MX362275B (es) | 2013-04-18 | 2019-01-10 | Novo Nordisk As | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. |
EP3058066A1 (en) | 2013-10-15 | 2016-08-24 | Novo Nordisk Health Care AG | Coagulation factor vii polypeptides |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第fviii因子ポリマー結合体 |
CN118085104A (zh) * | 2016-07-11 | 2024-05-28 | Opko生物科学有限公司 | 长效凝血因子及其制备方法 |
JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第fviii因子ポリマー結合体 |
WO2020163269A1 (en) * | 2019-02-04 | 2020-08-13 | Xenetic Biosciences, Inc. | Methods of using glycopolysialylated therapeutic proteins |
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CN109620963B (zh) * | 2012-05-16 | 2022-10-28 | 武田药品工业株式会社 | 用于肟键联的亲核性催化剂 |
CN106029106A (zh) * | 2014-02-12 | 2016-10-12 | 诺和诺德保健股份有限公司 | 凝血因子ix缀合物 |
CN106164097A (zh) * | 2014-04-11 | 2016-11-23 | 杰特有限公司 | 用于预防和治疗出血的半衰期延长的因子fviia以及为此的给药方案 |
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