CN101437397B - 核苷酸和低聚核苷酸前体药物 - Google Patents

核苷酸和低聚核苷酸前体药物 Download PDF

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Publication number
CN101437397B
CN101437397B CN2006800509299A CN200680050929A CN101437397B CN 101437397 B CN101437397 B CN 101437397B CN 2006800509299 A CN2006800509299 A CN 2006800509299A CN 200680050929 A CN200680050929 A CN 200680050929A CN 101437397 B CN101437397 B CN 101437397B
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China
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nhc
aryl
alkyl
cycloalkyl
heteroaryl
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Expired - Fee Related
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Chinese (zh)
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CN101437397A (zh
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R·P·依耶
S·帕德玛那博汉
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Spring Bank
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Spring Bank
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN2006800509299A 2005-12-13 2006-12-13 核苷酸和低聚核苷酸前体药物 Expired - Fee Related CN101437397B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201210257654.3A CN102796155B (zh) 2005-12-13 2006-12-13 核苷酸和低聚核苷酸前体药物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US60/750,036 2005-12-13
US80029406P 2006-05-15 2006-05-15
US60/800,294 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
US11/637,520 2006-12-12
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs

Related Child Applications (1)

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CN201210257654.3A Division CN102796155B (zh) 2005-12-13 2006-12-13 核苷酸和低聚核苷酸前体药物

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CN101437397A CN101437397A (zh) 2009-05-20
CN101437397B true CN101437397B (zh) 2012-09-05

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US (6) US8076303B2 (https=)
EP (3) EP3090748B1 (https=)
JP (1) JP5044854B2 (https=)
KR (2) KR101123534B1 (https=)
CN (2) CN101437397B (https=)
CY (2) CY1117576T1 (https=)
DK (2) DK3090748T3 (https=)
ES (2) ES2573928T3 (https=)
HR (1) HRP20160531T1 (https=)
HU (2) HUE029190T2 (https=)
IN (1) IN2015DN01786A (https=)
LT (1) LT3090748T (https=)
PL (2) PL1968612T3 (https=)
PT (1) PT3090748T (https=)
RS (1) RS54867B1 (https=)
SI (2) SI1968612T1 (https=)
WO (1) WO2007070598A2 (https=)

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WO2007070598A2 (en) 2007-06-21
WO2007070598A8 (en) 2008-12-31
WO2007070598A3 (en) 2008-10-30
EP1968612A2 (en) 2008-09-17
US20200087338A1 (en) 2020-03-19
CY1117576T1 (el) 2017-04-26
KR101123534B1 (ko) 2012-03-13
HRP20160531T1 (hr) 2016-08-12
ES2729657T3 (es) 2019-11-05
US20120264709A1 (en) 2012-10-18
KR101248873B1 (ko) 2013-04-02
US20070149462A1 (en) 2007-06-28
US8076303B2 (en) 2011-12-13
JP5044854B2 (ja) 2012-10-10
PL1968612T3 (pl) 2016-11-30
KR20110125677A (ko) 2011-11-21
EP1968612B1 (en) 2016-03-09
EP3553072A1 (en) 2019-10-16
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
SI3090748T1 (sl) 2019-09-30
ES2573928T3 (es) 2016-06-13
LT3090748T (lt) 2019-08-26
US10047114B2 (en) 2018-08-14
US8691787B2 (en) 2014-04-08
SI1968612T1 (sl) 2016-10-28
RS54867B1 (sr) 2016-10-31
EP3090748B1 (en) 2019-02-20
US20180273574A1 (en) 2018-09-27
HUE029190T2 (en) 2017-02-28
CY1121639T1 (el) 2020-07-31
JP2009519345A (ja) 2009-05-14
KR20080072084A (ko) 2008-08-05
DK1968612T3 (en) 2017-05-22
PL3090748T3 (pl) 2020-03-31
PT3090748T (pt) 2019-06-04
DK3090748T3 (da) 2019-05-27
IN2015DN01786A (https=) 2015-07-10
WO2007070598A9 (en) 2007-11-08
CN101437397A (zh) 2009-05-20
US10344046B2 (en) 2019-07-09
HUE044034T2 (hu) 2019-09-30
EP1968612A4 (en) 2013-01-09
EP3090748A1 (en) 2016-11-09
CN102796155B (zh) 2015-08-26
CN102796155A (zh) 2012-11-28

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