IN2015DN01786A - - Google Patents

Info

Publication number
IN2015DN01786A
IN2015DN01786A IN1786DEN2015A IN2015DN01786A IN 2015DN01786 A IN2015DN01786 A IN 2015DN01786A IN 1786DEN2015 A IN1786DEN2015 A IN 1786DEN2015A IN 2015DN01786 A IN2015DN01786 A IN 2015DN01786A
Authority
IN
India
Prior art keywords
subject
pronucleotide
administering
formula
need
Prior art date
Application number
Inventor
P Iyer Radhakrishnan
Padmanabhan Seetharamaiyer
Original Assignee
Spring Bank
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spring Bank filed Critical Spring Bank
Publication of IN2015DN01786A publication Critical patent/IN2015DN01786A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

A method for treating HBV in a subject in need thereof comprising administering to said subject a therapeutically effective amount of a pronucleotide according to Formula (I):
IN1786DEN2015 2005-12-13 2006-12-13 IN2015DN01786A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US80029406P 2006-05-15 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs

Publications (1)

Publication Number Publication Date
IN2015DN01786A true IN2015DN01786A (en) 2015-07-10

Family

ID=38194676

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1786DEN2015 IN2015DN01786A (en) 2005-12-13 2006-12-13

Country Status (17)

Country Link
US (6) US8076303B2 (en)
EP (3) EP1968612B1 (en)
JP (1) JP5044854B2 (en)
KR (2) KR101123534B1 (en)
CN (2) CN102796155B (en)
CY (2) CY1117576T1 (en)
DK (2) DK3090748T3 (en)
ES (2) ES2729657T3 (en)
HR (1) HRP20160531T1 (en)
HU (2) HUE029190T2 (en)
IN (1) IN2015DN01786A (en)
LT (1) LT3090748T (en)
PL (2) PL3090748T3 (en)
PT (1) PT3090748T (en)
RS (1) RS54867B1 (en)
SI (2) SI1968612T1 (en)
WO (1) WO2007070598A2 (en)

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KR101926419B1 (en) * 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. Design of oligonucleotide analogs as therapeutic agents
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JP6502267B2 (en) * 2013-02-18 2019-04-17 スプリング バンク ファーマシューティカルズ，インコーポレイテッド Design of short oligonucleotides as vaccine adjuvants and therapeutic agents
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US20180185404A1 (en) * 2015-07-02 2018-07-05 Spring Bank Pharmaceuticals, Inc. Compositions and methods for the treatment of viral infection
US20190070212A1 (en) * 2016-03-11 2019-03-07 Spring Bank Pharmaceuticals, Inc. Compounds and compositions for the treatment of infections
SG11201900154VA (en) * 2016-07-15 2019-02-27 Sperovie Biosciences Inc Compounds, compositions, and methods for the treatment of disease
JOP20170192A1 (en) * 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co Cyclic dinucleotide
US20200055883A1 (en) 2017-02-17 2020-02-20 Eisai R&D Management Co., Ltd. Cyclic di-nucleotides derivative for the treatment of cancer
AR113224A1 (en) 2017-04-28 2020-02-19 Novartis Ag ANTIBODY CONJUGATES INCLUDING A STING AGONIST
WO2019051488A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. Compounds compositions, and methods for the treatment of disease
US11707531B2 (en) * 2017-09-11 2023-07-25 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
CN110467646A (en) * 2018-05-09 2019-11-19 博瑞生物医药（苏州）股份有限公司 Dinucleotide pro-drug
CN110467647B (en) * 2018-05-09 2022-08-30 博瑞生物医药（苏州）股份有限公司 Process for preparing dinucleotide prodrug
CN111918870B (en) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 Deuterated oligonucleotides and prodrugs
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Also Published As

Publication number Publication date
KR101123534B1 (en) 2012-03-13
EP1968612B1 (en) 2016-03-09
RS54867B1 (en) 2016-10-31
JP5044854B2 (en) 2012-10-10
KR101248873B1 (en) 2013-04-02
US10344046B2 (en) 2019-07-09
US20120264709A1 (en) 2012-10-18
PL1968612T3 (en) 2016-11-30
CN101437397B (en) 2012-09-05
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
US20180273574A1 (en) 2018-09-27
ES2729657T3 (en) 2019-11-05
CN102796155B (en) 2015-08-26
CN101437397A (en) 2009-05-20
DK1968612T3 (en) 2017-05-22
SI1968612T1 (en) 2016-10-28
EP3090748B1 (en) 2019-02-20
SI3090748T1 (en) 2019-09-30
EP3090748A1 (en) 2016-11-09
CN102796155A (en) 2012-11-28
WO2007070598A8 (en) 2008-12-31
HRP20160531T1 (en) 2016-08-12
EP1968612A2 (en) 2008-09-17
US10047114B2 (en) 2018-08-14
US20200087338A1 (en) 2020-03-19
KR20110125677A (en) 2011-11-21
EP3553072A1 (en) 2019-10-16
US20070149462A1 (en) 2007-06-28
US8691787B2 (en) 2014-04-08
DK3090748T3 (en) 2019-05-27
WO2007070598A9 (en) 2007-11-08
JP2009519345A (en) 2009-05-14
HUE044034T2 (en) 2019-09-30
PT3090748T (en) 2019-06-04
HUE029190T2 (en) 2017-02-28
US8076303B2 (en) 2011-12-13
LT3090748T (en) 2019-08-26
KR20080072084A (en) 2008-08-05
CY1121639T1 (en) 2020-07-31
WO2007070598A2 (en) 2007-06-21
CY1117576T1 (en) 2017-04-26
EP1968612A4 (en) 2013-01-09
PL3090748T3 (en) 2020-03-31
ES2573928T3 (en) 2016-06-13
WO2007070598A3 (en) 2008-10-30

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