KR101123534B1 - 뉴클레오티드 및 올리고뉴클레오티드 전구약물 - Google Patents

뉴클레오티드 및 올리고뉴클레오티드 전구약물 Download PDF

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Publication number
KR101123534B1
KR101123534B1 KR1020087015713A KR20087015713A KR101123534B1 KR 101123534 B1 KR101123534 B1 KR 101123534B1 KR 1020087015713 A KR1020087015713 A KR 1020087015713A KR 20087015713 A KR20087015713 A KR 20087015713A KR 101123534 B1 KR101123534 B1 KR 101123534B1
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South Korea
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nhc
alkenyl
alkyl
aryl
cycloalkyl
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Expired - Fee Related
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KR1020087015713A
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English (en)
Korean (ko)
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KR20080072084A (ko
Inventor
라드하크리쉬난 피. 아이어
시타라마이어 파드마나반
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스프링 뱅크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020087015713A 2005-12-13 2006-12-13 뉴클레오티드 및 올리고뉴클레오티드 전구약물 Expired - Fee Related KR101123534B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US60/750,036 2005-12-13
US80029406P 2006-05-15 2006-05-15
US60/800,294 2006-05-15
US11/637,520 2006-12-12
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117025810A Division KR101248873B1 (ko) 2005-12-13 2006-12-13 뉴클레오티드 및 올리고뉴클레오티드 전구약물

Publications (2)

Publication Number Publication Date
KR20080072084A KR20080072084A (ko) 2008-08-05
KR101123534B1 true KR101123534B1 (ko) 2012-03-13

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KR1020087015713A Expired - Fee Related KR101123534B1 (ko) 2005-12-13 2006-12-13 뉴클레오티드 및 올리고뉴클레오티드 전구약물
KR1020117025810A Expired - Fee Related KR101248873B1 (ko) 2005-12-13 2006-12-13 뉴클레오티드 및 올리고뉴클레오티드 전구약물

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Country Status (17)

Country Link
US (6) US8076303B2 (https=)
EP (3) EP3090748B1 (https=)
JP (1) JP5044854B2 (https=)
KR (2) KR101123534B1 (https=)
CN (2) CN101437397B (https=)
CY (2) CY1117576T1 (https=)
DK (2) DK3090748T3 (https=)
ES (2) ES2573928T3 (https=)
HR (1) HRP20160531T1 (https=)
HU (2) HUE044034T2 (https=)
IN (1) IN2015DN01786A (https=)
LT (1) LT3090748T (https=)
PL (2) PL3090748T3 (https=)
PT (1) PT3090748T (https=)
RS (1) RS54867B1 (https=)
SI (2) SI3090748T1 (https=)
WO (1) WO2007070598A2 (https=)

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US8691971B2 (en) * 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
CN102307889A (zh) * 2008-12-23 2012-01-04 集润德斯股份公司 硫化剂及其用于寡核苷酸合成的用途
AU2015255202B2 (en) * 2009-07-06 2017-07-27 Wave Life Sciences Ltd. Novel nucleic acid prodrugs and methods of use thereof
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CN101659612B (zh) * 2009-09-24 2013-01-09 华润赛科药业有限责任公司 一种选择性酯化的方法
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Also Published As

Publication number Publication date
ES2729657T3 (es) 2019-11-05
US20120264709A1 (en) 2012-10-18
JP5044854B2 (ja) 2012-10-10
IN2015DN01786A (https=) 2015-07-10
EP1968612B1 (en) 2016-03-09
CN101437397A (zh) 2009-05-20
PL3090748T3 (pl) 2020-03-31
US20180273574A1 (en) 2018-09-27
EP1968612A4 (en) 2013-01-09
HRP20160531T1 (hr) 2016-08-12
US20070149462A1 (en) 2007-06-28
CY1117576T1 (el) 2017-04-26
CN102796155A (zh) 2012-11-28
KR101248873B1 (ko) 2013-04-02
PT3090748T (pt) 2019-06-04
KR20110125677A (ko) 2011-11-21
PL1968612T3 (pl) 2016-11-30
WO2007070598A2 (en) 2007-06-21
CN102796155B (zh) 2015-08-26
DK1968612T3 (en) 2017-05-22
EP3090748B1 (en) 2019-02-20
SI1968612T1 (sl) 2016-10-28
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
WO2007070598A9 (en) 2007-11-08
KR20080072084A (ko) 2008-08-05
LT3090748T (lt) 2019-08-26
HUE044034T2 (hu) 2019-09-30
ES2573928T3 (es) 2016-06-13
WO2007070598A8 (en) 2008-12-31
DK3090748T3 (da) 2019-05-27
CN101437397B (zh) 2012-09-05
US10047114B2 (en) 2018-08-14
EP3090748A1 (en) 2016-11-09
US20200087338A1 (en) 2020-03-19
US10344046B2 (en) 2019-07-09
CY1121639T1 (el) 2020-07-31
US8076303B2 (en) 2011-12-13
US8691787B2 (en) 2014-04-08
WO2007070598A3 (en) 2008-10-30
SI3090748T1 (sl) 2019-09-30
EP1968612A2 (en) 2008-09-17
RS54867B1 (sr) 2016-10-31
JP2009519345A (ja) 2009-05-14
HUE029190T2 (en) 2017-02-28
EP3553072A1 (en) 2019-10-16

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