HUE044034T2 - Nukleotid- és oligonukleotid-prodrogokat tartalmazó készítmények - Google Patents

Nukleotid- és oligonukleotid-prodrogokat tartalmazó készítmények

Info

Publication number
HUE044034T2
HUE044034T2 HUE16158945A HUE16158945A HUE044034T2 HU E044034 T2 HUE044034 T2 HU E044034T2 HU E16158945 A HUE16158945 A HU E16158945A HU E16158945 A HUE16158945 A HU E16158945A HU E044034 T2 HUE044034 T2 HU E044034T2
Authority
HU
Hungary
Prior art keywords
nucleotide
compositions
oligonucleotide prodrugs
prodrugs
oligonucleotide
Prior art date
Application number
HUE16158945A
Other languages
English (en)
Inventor
Radhakrishnan Iyer
Seetharamaiyer Padmanabhan
Original Assignee
Spring Bank Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spring Bank Pharmaceuticals Inc filed Critical Spring Bank Pharmaceuticals Inc
Publication of HUE044034T2 publication Critical patent/HUE044034T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
HUE16158945A 2005-12-13 2006-12-13 Nukleotid- és oligonukleotid-prodrogokat tartalmazó készítmények HUE044034T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US80029406P 2006-05-15 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs

Publications (1)

Publication Number Publication Date
HUE044034T2 true HUE044034T2 (hu) 2019-09-30

Family

ID=38194676

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE06848625A HUE029190T2 (hu) 2005-12-13 2006-12-13 Dinukleotid prodrogok
HUE16158945A HUE044034T2 (hu) 2005-12-13 2006-12-13 Nukleotid- és oligonukleotid-prodrogokat tartalmazó készítmények

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE06848625A HUE029190T2 (hu) 2005-12-13 2006-12-13 Dinukleotid prodrogok

Country Status (17)

Country Link
US (6) US8076303B2 (hu)
EP (3) EP3553072A1 (hu)
JP (1) JP5044854B2 (hu)
KR (2) KR101123534B1 (hu)
CN (2) CN102796155B (hu)
CY (2) CY1117576T1 (hu)
DK (2) DK3090748T3 (hu)
ES (2) ES2573928T3 (hu)
HR (1) HRP20160531T1 (hu)
HU (2) HUE029190T2 (hu)
IN (1) IN2015DN01786A (hu)
LT (1) LT3090748T (hu)
PL (2) PL1968612T3 (hu)
PT (1) PT3090748T (hu)
RS (1) RS54867B1 (hu)
SI (2) SI1968612T1 (hu)
WO (1) WO2007070598A2 (hu)

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CN110467647B (zh) * 2018-05-09 2022-08-30 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物的制备方法
CN110467646A (zh) * 2018-05-09 2019-11-19 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物
CN111918870B (zh) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
WO2019232392A1 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods for the treatment of bladder cancer
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Also Published As

Publication number Publication date
US10344046B2 (en) 2019-07-09
SI1968612T1 (sl) 2016-10-28
US20200087338A1 (en) 2020-03-19
EP3090748A1 (en) 2016-11-09
KR20110125677A (ko) 2011-11-21
US20180273574A1 (en) 2018-09-27
HUE029190T2 (hu) 2017-02-28
US10047114B2 (en) 2018-08-14
LT3090748T (lt) 2019-08-26
DK3090748T3 (da) 2019-05-27
RS54867B1 (sr) 2016-10-31
JP2009519345A (ja) 2009-05-14
HRP20160531T1 (hr) 2016-08-12
CN101437397A (zh) 2009-05-20
PL3090748T3 (pl) 2020-03-31
IN2015DN01786A (hu) 2015-07-10
CN102796155A (zh) 2012-11-28
EP1968612B1 (en) 2016-03-09
WO2007070598A8 (en) 2008-12-31
PL1968612T3 (pl) 2016-11-30
EP3553072A1 (en) 2019-10-16
WO2007070598A2 (en) 2007-06-21
KR101248873B1 (ko) 2013-04-02
WO2007070598A9 (en) 2007-11-08
EP1968612A4 (en) 2013-01-09
ES2573928T3 (es) 2016-06-13
WO2007070598A3 (en) 2008-10-30
CY1121639T1 (el) 2020-07-31
KR20080072084A (ko) 2008-08-05
SI3090748T1 (sl) 2019-09-30
US8691787B2 (en) 2014-04-08
JP5044854B2 (ja) 2012-10-10
CN101437397B (zh) 2012-09-05
ES2729657T3 (es) 2019-11-05
CY1117576T1 (el) 2017-04-26
EP3090748B1 (en) 2019-02-20
US8076303B2 (en) 2011-12-13
CN102796155B (zh) 2015-08-26
DK1968612T3 (en) 2017-05-22
US20120264709A1 (en) 2012-10-18
US20070149462A1 (en) 2007-06-28
EP1968612A2 (en) 2008-09-17
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
PT3090748T (pt) 2019-06-04
KR101123534B1 (ko) 2012-03-13

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