PL3090748T3 - Kompozycje zawierające proleki nukleotydowe i oligonukleotydowe - Google Patents

Kompozycje zawierające proleki nukleotydowe i oligonukleotydowe

Info

Publication number
PL3090748T3
PL3090748T3 PL16158945T PL16158945T PL3090748T3 PL 3090748 T3 PL3090748 T3 PL 3090748T3 PL 16158945 T PL16158945 T PL 16158945T PL 16158945 T PL16158945 T PL 16158945T PL 3090748 T3 PL3090748 T3 PL 3090748T3
Authority
PL
Poland
Prior art keywords
nucleotide
compositions
oligonucleotide prodrugs
prodrugs
oligonucleotide
Prior art date
Application number
PL16158945T
Other languages
English (en)
Inventor
Radhakrishnan P. Iyer
Seetharamaiyer Padmanabhan
Original Assignee
Spring Bank Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spring Bank Pharmaceuticals, Inc. filed Critical Spring Bank Pharmaceuticals, Inc.
Publication of PL3090748T3 publication Critical patent/PL3090748T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
PL16158945T 2005-12-13 2006-12-13 Kompozycje zawierające proleki nukleotydowe i oligonukleotydowe PL3090748T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US80029406P 2006-05-15 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs
EP16158945.2A EP3090748B1 (en) 2005-12-13 2006-12-13 Compositions comprising nucleotide and oligonucleotide prodrugs
EP06848625.7A EP1968612B1 (en) 2005-12-13 2006-12-13 Dinucleotide prodrugs

Publications (1)

Publication Number Publication Date
PL3090748T3 true PL3090748T3 (pl) 2020-03-31

Family

ID=38194676

Family Applications (2)

Application Number Title Priority Date Filing Date
PL16158945T PL3090748T3 (pl) 2005-12-13 2006-12-13 Kompozycje zawierające proleki nukleotydowe i oligonukleotydowe
PL06848625.7T PL1968612T3 (pl) 2005-12-13 2006-12-13 Proleki dinukleotydowe

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL06848625.7T PL1968612T3 (pl) 2005-12-13 2006-12-13 Proleki dinukleotydowe

Country Status (17)

Country Link
US (6) US8076303B2 (pl)
EP (3) EP3553072A1 (pl)
JP (1) JP5044854B2 (pl)
KR (2) KR101248873B1 (pl)
CN (2) CN101437397B (pl)
CY (2) CY1117576T1 (pl)
DK (2) DK3090748T3 (pl)
ES (2) ES2573928T3 (pl)
HR (1) HRP20160531T1 (pl)
HU (2) HUE029190T2 (pl)
IN (1) IN2015DN01786A (pl)
LT (1) LT3090748T (pl)
PL (2) PL3090748T3 (pl)
PT (1) PT3090748T (pl)
RS (1) RS54867B1 (pl)
SI (2) SI1968612T1 (pl)
WO (1) WO2007070598A2 (pl)

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CN110467647B (zh) * 2018-05-09 2022-08-30 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物的制备方法
CN111918870B (zh) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
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Also Published As

Publication number Publication date
KR101248873B1 (ko) 2013-04-02
DK1968612T3 (en) 2017-05-22
KR20080072084A (ko) 2008-08-05
US20120264709A1 (en) 2012-10-18
WO2007070598A3 (en) 2008-10-30
LT3090748T (lt) 2019-08-26
SI3090748T1 (sl) 2019-09-30
WO2007070598A2 (en) 2007-06-21
HRP20160531T1 (hr) 2016-08-12
EP1968612B1 (en) 2016-03-09
WO2007070598A9 (en) 2007-11-08
EP3090748A1 (en) 2016-11-09
CN102796155A (zh) 2012-11-28
WO2007070598A8 (en) 2008-12-31
CN101437397B (zh) 2012-09-05
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
CN101437397A (zh) 2009-05-20
EP1968612A4 (en) 2013-01-09
CY1117576T1 (el) 2017-04-26
US10344046B2 (en) 2019-07-09
IN2015DN01786A (pl) 2015-07-10
ES2729657T3 (es) 2019-11-05
EP3553072A1 (en) 2019-10-16
US20180273574A1 (en) 2018-09-27
KR20110125677A (ko) 2011-11-21
CN102796155B (zh) 2015-08-26
DK3090748T3 (da) 2019-05-27
US10047114B2 (en) 2018-08-14
US8076303B2 (en) 2011-12-13
CY1121639T1 (el) 2020-07-31
PT3090748T (pt) 2019-06-04
KR101123534B1 (ko) 2012-03-13
EP3090748B1 (en) 2019-02-20
SI1968612T1 (sl) 2016-10-28
HUE029190T2 (en) 2017-02-28
EP1968612A2 (en) 2008-09-17
RS54867B1 (sr) 2016-10-31
HUE044034T2 (hu) 2019-09-30
ES2573928T3 (es) 2016-06-13
US20200087338A1 (en) 2020-03-19
US20070149462A1 (en) 2007-06-28
PL1968612T3 (pl) 2016-11-30
JP5044854B2 (ja) 2012-10-10
JP2009519345A (ja) 2009-05-14
US8691787B2 (en) 2014-04-08

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