MX2020013322A - Sales de compuestos y cristales de los mismos. - Google Patents
Sales de compuestos y cristales de los mismos.Info
- Publication number
- MX2020013322A MX2020013322A MX2020013322A MX2020013322A MX2020013322A MX 2020013322 A MX2020013322 A MX 2020013322A MX 2020013322 A MX2020013322 A MX 2020013322A MX 2020013322 A MX2020013322 A MX 2020013322A MX 2020013322 A MX2020013322 A MX 2020013322A
- Authority
- MX
- Mexico
- Prior art keywords
- salts
- compound
- crystals
- compounds
- nonae
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000013078 crystal Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940088679 drug related substance Drugs 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención proporciona cristales de sales de amonio de (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39- bis(sulfanil)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27 -decaaza-34?5,39?5-difosfaoctaciclo[28.6.4.13,36.128,31.04,8.07,1 2.019,24.023,27]dotetrac onta-5,7,9,11,15,19,21,23,25-nonaeno-34,3 9-diona (compuesto (I)), sales de sodio del compuesto (I) o el compuesto (I), que presentan un potencial para usarse como sustancia farmacológica en productos farmacéuticos. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862764774P | 2018-08-16 | 2018-08-16 | |
PCT/JP2019/031951 WO2020036199A1 (en) | 2018-08-16 | 2019-08-14 | Salts of compounds and crystals thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020013322A true MX2020013322A (es) | 2021-02-22 |
Family
ID=69525441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020013322A MX2020013322A (es) | 2018-08-16 | 2019-08-14 | Sales de compuestos y cristales de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US11691990B2 (es) |
EP (1) | EP3837268A4 (es) |
JP (1) | JP6767589B1 (es) |
KR (1) | KR20210045352A (es) |
CN (1) | CN112041325B (es) |
AU (1) | AU2019322722A1 (es) |
BR (1) | BR112021001349A2 (es) |
CA (1) | CA3099904A1 (es) |
MX (1) | MX2020013322A (es) |
SG (1) | SG11202009262VA (es) |
TW (1) | TWI717804B (es) |
WO (1) | WO2020036199A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220111028A1 (en) | 2020-10-14 | 2022-04-14 | Boehringer Ingelheim International Gmbh | Combination Of A STING Agonist And A Complex Comprising A Cell Penetrating Peptide, A Cargo And A TLR Peptide Agonist |
Family Cites Families (40)
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---|---|---|---|---|
GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
WO2005089777A1 (en) | 2004-03-15 | 2005-09-29 | Karaolis David K R | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
IN2014MN02492A (es) | 2012-06-08 | 2015-07-17 | Aduro Biotech | |
JP6333843B2 (ja) | 2012-12-13 | 2018-05-30 | アデュロ バイオテック,インコーポレイテッド | 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法 |
ES2678194T3 (es) | 2012-12-19 | 2018-08-09 | Board Of Regents, The University Of Texas System | Determinación farmacéutica de una vía de señalización de dinucleótido cíclico de mamífero |
WO2014179335A1 (en) | 2013-04-29 | 2014-11-06 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
PT2996473T (pt) | 2013-05-18 | 2019-11-18 | Univ California | Composições e métodos para a ativação da sinalização dependente do ''estimulador de genes de interferão'' |
US20160287623A1 (en) | 2013-11-19 | 2016-10-06 | The University Of Chicago | Use of sting agonist as cancer treatment |
EP3071229A4 (en) | 2013-11-22 | 2017-05-10 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
MX2016015928A (es) * | 2014-06-04 | 2017-03-20 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting. |
WO2016079899A1 (ja) | 2014-11-20 | 2016-05-26 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Th1誘導性アジュバントおよびその用途 |
WO2016096577A1 (en) | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
US10011630B2 (en) | 2014-12-16 | 2018-07-03 | Invivogen | Cyclic dinucleotides for cytokine induction |
CN112626153A (zh) | 2014-12-17 | 2021-04-09 | 立博美华基因科技有限责任公司 | 用cGAMP或cGAsMP治疗癌症的方法 |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
AR103894A1 (es) | 2015-03-10 | 2017-06-14 | Aduro Biotech Inc | Composiciones y métodos para activar la señalización dependiente del estimulador del gen interferón |
WO2017011622A1 (en) | 2015-07-14 | 2017-01-19 | Spring Bank Pharmaceuticals, Inc. | Compounds and compositions that induce rig-i-and other pattern recongnition receptors |
US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
GEP20207182B (en) | 2015-08-13 | 2020-11-25 | Merck Sharp & Dohme | Cyclic di-nucleotide compounds as sting agonists |
US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
US20170056448A1 (en) | 2015-09-01 | 2017-03-02 | Ifm Therapeutics, Inc | Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same |
WO2017075477A1 (en) | 2015-10-28 | 2017-05-04 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
MY194058A (en) | 2016-01-11 | 2022-11-10 | Innate Tumor Immunity Inc | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | タンパク質調節物質として有用な複素環アミド |
US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
EP3574018A4 (en) | 2017-01-27 | 2020-10-07 | Silverback Therapeutics, Inc. | CONJUGATES TARGETING TUMORS AND THEIR METHODS OF USE |
US20200055883A1 (en) * | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
WO2018198084A1 (en) | 2017-04-27 | 2018-11-01 | Lupin Limited | Cyclic di-nucleotide compounds with tricyclic nucleobases |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
JP6909061B2 (ja) | 2017-06-13 | 2021-07-28 | 株式会社三共 | 遊技機 |
-
2019
- 2019-08-14 JP JP2019565031A patent/JP6767589B1/ja active Active
- 2019-08-14 KR KR1020207030563A patent/KR20210045352A/ko not_active Application Discontinuation
- 2019-08-14 TW TW108128873A patent/TWI717804B/zh not_active IP Right Cessation
- 2019-08-14 CA CA3099904A patent/CA3099904A1/en active Pending
- 2019-08-14 AU AU2019322722A patent/AU2019322722A1/en not_active Abandoned
- 2019-08-14 MX MX2020013322A patent/MX2020013322A/es unknown
- 2019-08-14 SG SG11202009262VA patent/SG11202009262VA/en unknown
- 2019-08-14 EP EP19850709.7A patent/EP3837268A4/en active Pending
- 2019-08-14 CN CN201980025277.0A patent/CN112041325B/zh active Active
- 2019-08-14 US US17/058,406 patent/US11691990B2/en active Active
- 2019-08-14 BR BR112021001349-0A patent/BR112021001349A2/pt not_active Application Discontinuation
- 2019-08-14 WO PCT/JP2019/031951 patent/WO2020036199A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN112041325A (zh) | 2020-12-04 |
KR20210045352A (ko) | 2021-04-26 |
US20210198282A1 (en) | 2021-07-01 |
BR112021001349A2 (pt) | 2021-04-20 |
EP3837268A1 (en) | 2021-06-23 |
CA3099904A1 (en) | 2020-02-20 |
US11691990B2 (en) | 2023-07-04 |
TWI717804B (zh) | 2021-02-01 |
EP3837268A4 (en) | 2022-04-20 |
JP2020529967A (ja) | 2020-10-15 |
CN112041325B (zh) | 2023-10-24 |
WO2020036199A1 (en) | 2020-02-20 |
JP6767589B1 (ja) | 2020-10-14 |
AU2019322722A1 (en) | 2020-10-15 |
SG11202009262VA (en) | 2020-10-29 |
TW202015701A (zh) | 2020-05-01 |
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