CN101143851B - 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 - Google Patents
川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 Download PDFInfo
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- CN101143851B CN101143851B CN2007101634771A CN200710163477A CN101143851B CN 101143851 B CN101143851 B CN 101143851B CN 2007101634771 A CN2007101634771 A CN 2007101634771A CN 200710163477 A CN200710163477 A CN 200710163477A CN 101143851 B CN101143851 B CN 101143851B
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- acid
- methoxy
- compound
- pharmaceutically acceptable
- ligustrazine
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- -1 Ligustrazine aromatic acid ether derivatives Chemical class 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
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- 125000005504 styryl group Chemical group 0.000 claims abstract description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 20
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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- QFOVBCHWFLWCSZ-UHFFFAOYSA-N methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate Chemical compound COC1=CC(C(=O)OC)=CC=C1OCC1=NC(C)=C(C)N=C1C QFOVBCHWFLWCSZ-UHFFFAOYSA-N 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
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|---|---|---|---|
| CN2007101634771A CN101143851B (zh) | 2007-10-26 | 2007-10-26 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
| JP2010530261A JP5265691B2 (ja) | 2007-10-26 | 2008-10-27 | リグストラジン芳香族酸エーテル類化合物、生成方法と薬物化合物及び応用 |
| US12/681,623 US8350033B2 (en) | 2007-10-26 | 2008-10-27 | 4-((3, 5, 6-trimethylpyrazine-2-yl) methoxyl) benzoic acid and its derivatives |
| AT08843800T ATE545634T1 (de) | 2007-10-26 | 2008-10-27 | Aromatisches säureether-derivat aus ligustrazin, herstellungsverfahren, pharmazeutische zusammensetzung und anwendung |
| EP08843800A EP2213666B1 (en) | 2007-10-26 | 2008-10-27 | Ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application |
| ES08843800T ES2382979T3 (es) | 2007-10-26 | 2008-10-27 | Derivado éter del ácido aromático de ligustrazina, su método de preparación, composición farmacéutica y aplicación |
| PCT/CN2008/072840 WO2009056070A1 (en) | 2007-10-26 | 2008-10-27 | Ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101634771A CN101143851B (zh) | 2007-10-26 | 2007-10-26 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
Publications (2)
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|---|---|
| CN101143851A CN101143851A (zh) | 2008-03-19 |
| CN101143851B true CN101143851B (zh) | 2010-07-21 |
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| CN2007101634771A Active CN101143851B (zh) | 2007-10-26 | 2007-10-26 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
Country Status (7)
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| US (1) | US8350033B2 (enExample) |
| EP (1) | EP2213666B1 (enExample) |
| JP (1) | JP5265691B2 (enExample) |
| CN (1) | CN101143851B (enExample) |
| AT (1) | ATE545634T1 (enExample) |
| ES (1) | ES2382979T3 (enExample) |
| WO (1) | WO2009056070A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143851B (zh) * | 2007-10-26 | 2010-07-21 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
| CN101812025B (zh) * | 2010-04-15 | 2011-12-07 | 李家明 | 吡嗪芳酸醚类化合物、制备方法和医药应用 |
| CN101851209B (zh) * | 2010-06-21 | 2012-09-19 | 合肥医工医药有限公司 | 咪唑乙基香草酸醚、其制备方法及其医药用途 |
| CN102675401B (zh) * | 2011-03-09 | 2014-08-13 | 雷海民 | 抗肿瘤药物lqc-y的制备及其应用 |
| CN104151388B (zh) * | 2011-03-09 | 2016-08-31 | 思路迪（北京）医药科技有限公司 | 抗肿瘤药物lqc-y的制备及其应用 |
| CN102675228B (zh) | 2011-03-16 | 2014-08-13 | 雷海民 | 一种治疗缺血性脑损伤中风及其后遗症的药物与制备方法 |
| CN103467383B (zh) * | 2013-09-13 | 2015-07-15 | 上海海虹实业(集团)巢湖今辰药业有限公司 | 一种丹皮酚与奥扎格雷偶联物及其药物组合物、医药用途 |
| CN104513207B (zh) * | 2013-10-08 | 2017-06-20 | 昆药集团股份有限公司 | 一种苄醇醚类化合物及其制备方法、制剂与应用 |
| CN104557740B (zh) * | 2013-10-17 | 2018-01-02 | 雷海民 | 具有神经保护活性的川芎嗪取代苯甲酸类衍生物(lqc‑a)及其应用 |
| CN103864768B (zh) * | 2014-03-04 | 2016-04-06 | 广西师范大学 | 川芎嗪茋类衍生物及其制备方法与应用 |
| CN105801496B (zh) * | 2014-12-31 | 2018-03-13 | 广州喜鹊医药有限公司 | 三氟乙酰肼类化合物及其制备方法和在制药中的应用 |
| CN105017165B (zh) * | 2015-07-07 | 2018-04-03 | 广州喜鹊医药有限公司 | 一种新的吡嗪衍生物及其制备方法和医药应用 |
| CN108456179B (zh) * | 2017-02-20 | 2021-09-28 | 雷鹏程 | 具有神经保护作用的化合物tva-x及其制备方法和应用 |
| CN107556251B (zh) * | 2017-08-23 | 2018-06-22 | 广东昊邦医药健康有限责任公司 | 一种磷酸川芎嗪衍生化合物及其药物组合物 |
| CN112028875B (zh) * | 2019-06-04 | 2023-08-15 | 南昌弘益科技有限公司 | 一类pgi2蛋白激动剂、txa2蛋白抑制剂的酸酐类化合物 |
| CN110749679B (zh) * | 2019-11-08 | 2022-11-01 | 华熙生物科技股份有限公司 | 一种三甲基吡嗪残留的检测方法 |
| CN111825664B (zh) * | 2020-08-01 | 2023-01-17 | 泰州学院 | 一种川芎嗪衍生物、制备方法和医药用途 |
| CN114805224B (zh) * | 2022-04-01 | 2024-03-22 | 山东大学 | 一种川芎嗪查尔酮衍生物及其制备方法与应用 |
| CN115201372B (zh) * | 2022-07-14 | 2023-11-10 | 四川新绿色药业科技发展有限公司 | 一种同时检测川芎和水蛭的薄层色谱方法 |
| CN116063237B (zh) * | 2023-02-20 | 2025-11-21 | 武汉科技大学 | 一类no供体型川芎嗪衍生物、制备方法、组合物及用途 |
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| CN101012201A (zh) * | 2007-02-05 | 2007-08-08 | 中国药科大学 | 川芎嗪衍生物、其制备方法及其医药用途 |
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| CN1184209C (zh) * | 2002-12-20 | 2005-01-12 | 山东大学 | 川芎醇酯类衍生物及其制备方法和含有川芎醇酯类衍生物的药物组合物与应用 |
| CN101143851B (zh) * | 2007-10-26 | 2010-07-21 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
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| EP2213666B1 (en) | 2012-02-15 |
| ATE545634T1 (de) | 2012-03-15 |
| EP2213666A4 (en) | 2010-11-17 |
| US20100228029A1 (en) | 2010-09-09 |
| CN101143851A (zh) | 2008-03-19 |
| WO2009056070A1 (en) | 2009-05-07 |
| JP5265691B2 (ja) | 2013-08-14 |
| EP2213666A1 (en) | 2010-08-04 |
| US8350033B2 (en) | 2013-01-08 |
| ES2382979T3 (es) | 2012-06-15 |
| JP2011500736A (ja) | 2011-01-06 |
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