ES2382979T3 - Derivado éter del ácido aromático de ligustrazina, su método de preparación, composición farmacéutica y aplicación - Google Patents
Derivado éter del ácido aromático de ligustrazina, su método de preparación, composición farmacéutica y aplicación Download PDFInfo
- Publication number
- ES2382979T3 ES2382979T3 ES08843800T ES08843800T ES2382979T3 ES 2382979 T3 ES2382979 T3 ES 2382979T3 ES 08843800 T ES08843800 T ES 08843800T ES 08843800 T ES08843800 T ES 08843800T ES 2382979 T3 ES2382979 T3 ES 2382979T3
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- ES
- Spain
- Prior art keywords
- acid
- ligustrazine
- trimethylpyrazine
- aromatic
- reduced pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FINHMKGKINIASC-UHFFFAOYSA-N tetramethyl-pyrazine Natural products CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title description 5
- 150000002170 ethers Chemical class 0.000 title description 2
- -1 Ligustrazine aromatic acid ether derivative Chemical class 0.000 claims abstract description 41
- 125000005504 styryl group Chemical group 0.000 claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 41
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- 239000007787 solid Substances 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 25
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 23
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 18
- HOPVUIZLMIEGMJ-UHFFFAOYSA-N 2-(bromomethyl)-3,5,6-trimethylpyrazine Chemical compound CC1=NC(C)=C(CBr)N=C1C HOPVUIZLMIEGMJ-UHFFFAOYSA-N 0.000 claims description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 14
- 238000001704 evaporation Methods 0.000 claims description 13
- 230000008020 evaporation Effects 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 12
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 12
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims description 12
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- 208000026106 cerebrovascular disease Diseases 0.000 claims description 10
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- 159000000032 aromatic acids Chemical class 0.000 claims description 9
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- POSNCTVMUZDYGJ-UHFFFAOYSA-N 4-methoxy-3-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1OCC1=NC(C)=C(C)N=C1C POSNCTVMUZDYGJ-UHFFFAOYSA-N 0.000 claims description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
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- 235000015320 potassium carbonate Nutrition 0.000 claims description 6
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- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims description 6
- TYZVLOKXCAMNQF-UHFFFAOYSA-N 4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoic acid Chemical compound N1=C(C)C(C)=NC(C)=C1COC1=CC=C(C(O)=O)C=C1 TYZVLOKXCAMNQF-UHFFFAOYSA-N 0.000 claims description 5
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 150000007530 organic bases Chemical class 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017550 sodium carbonate Nutrition 0.000 claims description 4
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 229960002317 succinimide Drugs 0.000 claims description 3
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
- 125000003368 amide group Chemical group 0.000 claims description 2
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
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- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 57
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 36
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 28
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical group [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 14
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710163477 | 2007-10-26 | ||
| CN2007101634771A CN101143851B (zh) | 2007-10-26 | 2007-10-26 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
| PCT/CN2008/072840 WO2009056070A1 (en) | 2007-10-26 | 2008-10-27 | Ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application |
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| WO (1) | WO2009056070A1 (enExample) |
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| CN101143851B (zh) * | 2007-10-26 | 2010-07-21 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
| CN101812025B (zh) * | 2010-04-15 | 2011-12-07 | 李家明 | 吡嗪芳酸醚类化合物、制备方法和医药应用 |
| CN101851209B (zh) * | 2010-06-21 | 2012-09-19 | 合肥医工医药有限公司 | 咪唑乙基香草酸醚、其制备方法及其医药用途 |
| CN102675401B (zh) * | 2011-03-09 | 2014-08-13 | 雷海民 | 抗肿瘤药物lqc-y的制备及其应用 |
| CN104151388B (zh) * | 2011-03-09 | 2016-08-31 | 思路迪（北京）医药科技有限公司 | 抗肿瘤药物lqc-y的制备及其应用 |
| CN102675228B (zh) | 2011-03-16 | 2014-08-13 | 雷海民 | 一种治疗缺血性脑损伤中风及其后遗症的药物与制备方法 |
| CN103467383B (zh) * | 2013-09-13 | 2015-07-15 | 上海海虹实业(集团)巢湖今辰药业有限公司 | 一种丹皮酚与奥扎格雷偶联物及其药物组合物、医药用途 |
| CN104513207B (zh) * | 2013-10-08 | 2017-06-20 | 昆药集团股份有限公司 | 一种苄醇醚类化合物及其制备方法、制剂与应用 |
| CN104557740B (zh) * | 2013-10-17 | 2018-01-02 | 雷海民 | 具有神经保护活性的川芎嗪取代苯甲酸类衍生物(lqc‑a)及其应用 |
| CN103864768B (zh) * | 2014-03-04 | 2016-04-06 | 广西师范大学 | 川芎嗪茋类衍生物及其制备方法与应用 |
| CN105801496B (zh) * | 2014-12-31 | 2018-03-13 | 广州喜鹊医药有限公司 | 三氟乙酰肼类化合物及其制备方法和在制药中的应用 |
| CN105017165B (zh) * | 2015-07-07 | 2018-04-03 | 广州喜鹊医药有限公司 | 一种新的吡嗪衍生物及其制备方法和医药应用 |
| CN108456179B (zh) * | 2017-02-20 | 2021-09-28 | 雷鹏程 | 具有神经保护作用的化合物tva-x及其制备方法和应用 |
| CN107556251B (zh) * | 2017-08-23 | 2018-06-22 | 广东昊邦医药健康有限责任公司 | 一种磷酸川芎嗪衍生化合物及其药物组合物 |
| CN112028875B (zh) * | 2019-06-04 | 2023-08-15 | 南昌弘益科技有限公司 | 一类pgi2蛋白激动剂、txa2蛋白抑制剂的酸酐类化合物 |
| CN110749679B (zh) * | 2019-11-08 | 2022-11-01 | 华熙生物科技股份有限公司 | 一种三甲基吡嗪残留的检测方法 |
| CN111825664B (zh) * | 2020-08-01 | 2023-01-17 | 泰州学院 | 一种川芎嗪衍生物、制备方法和医药用途 |
| CN114805224B (zh) * | 2022-04-01 | 2024-03-22 | 山东大学 | 一种川芎嗪查尔酮衍生物及其制备方法与应用 |
| CN115201372B (zh) * | 2022-07-14 | 2023-11-10 | 四川新绿色药业科技发展有限公司 | 一种同时检测川芎和水蛭的薄层色谱方法 |
| CN116063237B (zh) * | 2023-02-20 | 2025-11-21 | 武汉科技大学 | 一类no供体型川芎嗪衍生物、制备方法、组合物及用途 |
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| CN1184209C (zh) * | 2002-12-20 | 2005-01-12 | 山东大学 | 川芎醇酯类衍生物及其制备方法和含有川芎醇酯类衍生物的药物组合物与应用 |
| CN101012201B (zh) * | 2007-02-05 | 2010-07-28 | 中国药科大学 | 川芎嗪衍生物、其制备方法及其医药用途 |
| CN101143851B (zh) * | 2007-10-26 | 2010-07-21 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
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|---|---|
| EP2213666B1 (en) | 2012-02-15 |
| ATE545634T1 (de) | 2012-03-15 |
| EP2213666A4 (en) | 2010-11-17 |
| CN101143851B (zh) | 2010-07-21 |
| US20100228029A1 (en) | 2010-09-09 |
| CN101143851A (zh) | 2008-03-19 |
| WO2009056070A1 (en) | 2009-05-07 |
| JP5265691B2 (ja) | 2013-08-14 |
| EP2213666A1 (en) | 2010-08-04 |
| US8350033B2 (en) | 2013-01-08 |
| JP2011500736A (ja) | 2011-01-06 |
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