CN102675401B - 抗肿瘤药物lqc-y的制备及其应用 - Google Patents
抗肿瘤药物lqc-y的制备及其应用 Download PDFInfo
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- CN102675401B CN102675401B CN201110055102.XA CN201110055102A CN102675401B CN 102675401 B CN102675401 B CN 102675401B CN 201110055102 A CN201110055102 A CN 201110055102A CN 102675401 B CN102675401 B CN 102675401B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (3)
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CN201410321529.3A CN104151388B (zh) | 2011-03-09 | 2011-03-09 | 抗肿瘤药物lqc-y的制备及其应用 |
CN201110055102.XA CN102675401B (zh) | 2011-03-09 | 2011-03-09 | 抗肿瘤药物lqc-y的制备及其应用 |
PCT/CN2011/081530 WO2012119458A1 (zh) | 2011-03-09 | 2011-10-28 | 抗肿瘤药物lqc-y的合成及其应用 |
US14/017,857 US9321804B2 (en) | 2011-03-09 | 2013-09-04 | Synthesis and use of anti-tumor drug LQC-Y |
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CN102225913B (zh) * | 2011-04-07 | 2013-09-04 | 栗进才 | 大黄酸衍生物以及它们的治疗用途 |
CN105315321B (zh) * | 2014-07-01 | 2018-10-16 | 思路迪(北京)医药科技有限公司 | 具有抗肿瘤作用的化合物及其制备方法和应用 |
CN105622704B (zh) * | 2014-10-29 | 2018-09-28 | 思路迪(北京)医药科技有限公司 | 抗肿瘤药物x-toa的制备方法及其应用 |
CN106478760B (zh) * | 2015-09-01 | 2018-10-16 | 思路迪(北京)医药科技有限公司 | 具有抗肿瘤作用的三帖类衍生物tba-x及其制备方法和应用 |
CN108350023B (zh) * | 2015-12-14 | 2021-01-08 | 四川思路迪药业有限公司 | 一种具有抗癌作用的化合物及其制备方法和应用 |
CN107011406A (zh) * | 2016-01-28 | 2017-08-04 | 思路迪(北京)医药科技有限公司 | 一种具有抗肿瘤作用的化合物及其制备方法和应用 |
CN105669823A (zh) * | 2016-03-04 | 2016-06-15 | 南京大学 | 一类含哌嗪骨架的甘草次酸衍生物、其制备方法及应用 |
CN109867709B (zh) * | 2017-12-01 | 2021-03-23 | 薪火炙药(北京)科技有限公司 | 具有抗肿瘤作用的甘草次酸系列衍生物(toga-x)的制备方法和应用 |
CN109867708B (zh) * | 2017-12-01 | 2021-03-23 | 薪火炙药(北京)科技有限公司 | 具有抗肿瘤作用的甘草次酸系列衍生物(tnga-x)的制备方法和应用 |
CN108033926B (zh) * | 2018-01-16 | 2020-11-06 | 西南大学 | 大黄素衍生物并唑类化合物及其制备方法和应用 |
CN110857295B (zh) * | 2018-08-22 | 2021-05-04 | 薪火炙药(北京)科技有限公司 | 具有选择性抗肝癌作用的黄酮-川芎嗪类化合物ch-x及其制备方法和应用 |
CN113603743B (zh) * | 2021-08-06 | 2022-07-15 | 南通大学 | 一类具有联合治疗作用的cddo/川芎嗪醇杂合物及其制备方法和用途 |
CN115873062B (zh) * | 2021-09-30 | 2024-04-09 | 深圳枫语生物医药科技有限公司 | 一种熊果酸吡嗪衍生物及其应用、制备方法 |
CN115819489A (zh) * | 2022-11-09 | 2023-03-21 | 遵义医科大学 | 茯苓酸衍生物、其制备方法及其应用 |
CN115677811A (zh) * | 2022-11-09 | 2023-02-03 | 遵义医科大学 | 茯苓酸衍生物、抗肿瘤药物中的应用及制备方法 |
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CN101143851A (zh) * | 2007-10-26 | 2008-03-19 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
CN101805390A (zh) * | 2010-04-13 | 2010-08-18 | 暨南大学 | 一种雷公藤红素衍生物及其用途 |
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CN101143851A (zh) * | 2007-10-26 | 2008-03-19 | 李家明 | 川芎嗪芳酸醚类衍生物、制备方法和药物组合物与应用 |
CN101805390A (zh) * | 2010-04-13 | 2010-08-18 | 暨南大学 | 一种雷公藤红素衍生物及其用途 |
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US9321804B2 (en) | 2016-04-26 |
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WO2012119458A1 (zh) | 2012-09-13 |
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Application publication date: 20120919 Assignee: Sichuan thought Kangrui Pharmaceutical Co.,Ltd. Assignor: 3D MEDICINES, Ltd. Contract record no.: X2022510000046 Denomination of invention: Preparation and application of antineoplastic drug LQC-Y Granted publication date: 20140813 License type: Common License Record date: 20220928 |
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Address after: 100176 101, Floor 1, Building 6, Zone 3, Yard 7, Liangshuihe 1st Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing (Yizhuang Cluster, High-end Industrial Zone, Beijing Pilot Free Trade Zone) Patentee after: 3D MEDICINES, Ltd. Address before: Room 1603, building 3, 88 Kechuang 6th Street, Beijing Economic and Technological Development Zone, Beijing Patentee before: 3D MEDICINES, Ltd. |