CN100528233C - 不愉快味道改善了的包覆制剂的制造方法 - Google Patents

不愉快味道改善了的包覆制剂的制造方法 Download PDF

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Publication number
CN100528233C
CN100528233C CNB2004800322353A CN200480032235A CN100528233C CN 100528233 C CN100528233 C CN 100528233C CN B2004800322353 A CNB2004800322353 A CN B2004800322353A CN 200480032235 A CN200480032235 A CN 200480032235A CN 100528233 C CN100528233 C CN 100528233C
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China
Prior art keywords
waxy substance
coated preparation
granule
manufacture method
weight
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English (en)
Chinese (zh)
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CN1874759A (zh
Inventor
田中宏
本多刚
北岛秀明
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication of CN1874759A publication Critical patent/CN1874759A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2004800322353A 2003-10-29 2004-10-27 不愉快味道改善了的包覆制剂的制造方法 Active CN100528233C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003368891 2003-10-29
JP368891/2003 2003-10-29

Publications (2)

Publication Number Publication Date
CN1874759A CN1874759A (zh) 2006-12-06
CN100528233C true CN100528233C (zh) 2009-08-19

Family

ID=34510363

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800322353A Active CN100528233C (zh) 2003-10-29 2004-10-27 不愉快味道改善了的包覆制剂的制造方法

Country Status (5)

Country Link
JP (1) JP3981134B2 (ja)
KR (1) KR101168189B1 (ja)
CN (1) CN100528233C (ja)
TW (1) TWI367767B (ja)
WO (1) WO2005039538A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275088B2 (en) * 2005-02-25 2018-09-26 Takeda Pharmaceutical Company Limited Method for producing granules
JP2011153075A (ja) * 2008-04-04 2011-08-11 Shionogi & Co Ltd 水懸濁性を向上させた細粒剤
JP4336380B1 (ja) * 2008-11-06 2009-09-30 塩野義製薬株式会社 水懸濁性を向上させた細粒剤
WO2015152190A1 (ja) * 2014-03-31 2015-10-08 富山化学工業株式会社 セファロスポリンエステルを含む粒状固形製剤およびその製造方法
CN104586854B (zh) * 2014-12-24 2017-08-15 石家庄四药有限公司 头孢呋辛酯药物组合物及其制备方法
JP6809675B2 (ja) * 2016-10-14 2021-01-06 ハウスウェルネスフーズ株式会社 植物抽出物を含有する口腔内即溶性顆粒の製造方法
SG10202109130WA (en) * 2017-02-21 2021-09-29 Ea Pharma Co Ltd Granular preparation
CN114340601A (zh) * 2019-09-25 2022-04-12 耐贝医药株式会社 掩盖了令人不快的味道的颗粒剂及其制造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948622A (en) * 1987-12-23 1990-08-14 Shin-Etsu Chemical Co., Ltd. Method for the preparation of coated solid medicament form
US6217910B1 (en) * 1995-07-21 2001-04-17 Daiichi Pharmaceutical Co., Ltd. Granular preparation and producing process thereof
US6238704B1 (en) * 1996-09-13 2001-05-29 Shionogi & Co., Ltd. Sustained-release preparation utilizing thermal change and process for the production thereof
JP4300821B2 (ja) * 2002-03-05 2009-07-22 住友化学株式会社 アミノ酸化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58214333A (ja) * 1982-06-04 1983-12-13 Dai Ichi Seiyaku Co Ltd 粒状物
JPH0647531B2 (ja) * 1986-02-06 1994-06-22 第一製薬株式会社 徐放性粒状物の製造法
JPS6327423A (ja) * 1986-07-17 1988-02-05 Shionogi & Co Ltd 固形製剤のコ−テイング法
JPH01287021A (ja) * 1988-05-13 1989-11-17 Shin Etsu Chem Co Ltd ワックス複覆薬剤の製造方法
JP3130058B2 (ja) * 1991-02-15 2001-01-31 第一製薬株式会社 マスクされた粒状物
JP2960790B2 (ja) * 1991-03-25 1999-10-12 塩野義製薬株式会社 経口投与用セファロスポリン水和物結晶
JP3006901B2 (ja) * 1991-03-29 2000-02-07 塩野義製薬株式会社 被覆製剤
JP2987813B2 (ja) * 1993-07-12 1999-12-06 住友製薬株式会社 ワックス被覆製剤およびその製法
JP3776941B2 (ja) * 1993-12-24 2006-05-24 塩野義製薬株式会社 味覚の改善された顆粒剤及びその製造方法
JP3466921B2 (ja) * 1998-06-03 2003-11-17 大塚製薬株式会社 味マスキング医薬製剤
JP2001270821A (ja) * 2000-03-23 2001-10-02 Eisai Co Ltd 服用感が優れた散剤
JP2001302497A (ja) * 2000-04-21 2001-10-31 Eisai Co Ltd 混合性に優れた散剤
JP3797605B2 (ja) * 2002-03-20 2006-07-19 旭化成ファーマ株式会社 粒状被覆製剤の製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948622A (en) * 1987-12-23 1990-08-14 Shin-Etsu Chemical Co., Ltd. Method for the preparation of coated solid medicament form
US6217910B1 (en) * 1995-07-21 2001-04-17 Daiichi Pharmaceutical Co., Ltd. Granular preparation and producing process thereof
US6238704B1 (en) * 1996-09-13 2001-05-29 Shionogi & Co., Ltd. Sustained-release preparation utilizing thermal change and process for the production thereof
JP4300821B2 (ja) * 2002-03-05 2009-07-22 住友化学株式会社 アミノ酸化合物

Also Published As

Publication number Publication date
JPWO2005039538A1 (ja) 2007-11-22
KR20060095564A (ko) 2006-08-31
CN1874759A (zh) 2006-12-06
WO2005039538A1 (ja) 2005-05-06
JP3981134B2 (ja) 2007-09-26
TWI367767B (en) 2012-07-11
TW200515923A (en) 2005-05-16
KR101168189B1 (ko) 2012-07-25

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