TW200515923A - Method for producing a coat formulation improved discomfort taste - Google Patents
Method for producing a coat formulation improved discomfort tasteInfo
- Publication number
- TW200515923A TW200515923A TW093132662A TW93132662A TW200515923A TW 200515923 A TW200515923 A TW 200515923A TW 093132662 A TW093132662 A TW 093132662A TW 93132662 A TW93132662 A TW 93132662A TW 200515923 A TW200515923 A TW 200515923A
- Authority
- TW
- Taiwan
- Prior art keywords
- wax
- taste
- substance
- producing
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided is a flavor-improved coated preparation without unpleasant taste which can be produced by conducting a heat treatment to a raw granular preparation comprising a pharmaceutical composition and a wax-like substance, further adding a wax-like substance powder at the temperature that the surface of the wax-like substance is moisturized, and proceeding heat-molten coating to the surface of said raw granular preparation. In addition, the administration can be further improved by mixing the said coated preparation with a sweet-taste subtilized granule which is obtained by using a binding solution comprising sweetening agent and binder dissolved or dispersed therein, and then forming a granule by means of a wetting method.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003368891 | 2003-10-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200515923A true TW200515923A (en) | 2005-05-16 |
TWI367767B TWI367767B (en) | 2012-07-11 |
Family
ID=34510363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093132662A TWI367767B (en) | 2003-10-29 | 2004-10-28 | Method for producing a coat formulation improved discomfort taste |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP3981134B2 (en) |
KR (1) | KR101168189B1 (en) |
CN (1) | CN100528233C (en) |
TW (1) | TWI367767B (en) |
WO (1) | WO2005039538A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8871273B2 (en) | 2005-02-25 | 2014-10-28 | Takeda Pharmaceutical Company Limited | Method for producing granules |
JP2011153075A (en) * | 2008-04-04 | 2011-08-11 | Shionogi & Co Ltd | Fine granule having improved suspension performance in water |
JP4336380B1 (en) * | 2008-11-06 | 2009-09-30 | 塩野義製薬株式会社 | Fine granules with improved water suspension |
WO2015152190A1 (en) * | 2014-03-31 | 2015-10-08 | 富山化学工業株式会社 | Granular solid formulation containing cephalosporin ester, and method for producing same |
CN104586854B (en) * | 2014-12-24 | 2017-08-15 | 石家庄四药有限公司 | Cefuroxime axetil pharmaceutical composition and preparation method thereof |
JP6809675B2 (en) * | 2016-10-14 | 2021-01-06 | ハウスウェルネスフーズ株式会社 | Method for Producing Immediate Oral Granules Containing Plant Extract |
SG10202109130WA (en) * | 2017-02-21 | 2021-09-29 | Ea Pharma Co Ltd | Granular preparation |
US20230016901A1 (en) * | 2019-09-25 | 2023-01-19 | Nobelpharma Co., Ltd. | Granule in which unpleasant taste is masked and method for producing granule |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58214333A (en) * | 1982-06-04 | 1983-12-13 | Dai Ichi Seiyaku Co Ltd | Granular substance |
JPH0647531B2 (en) * | 1986-02-06 | 1994-06-22 | 第一製薬株式会社 | Method for manufacturing sustained-release granules |
JPS6327423A (en) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | Coating method for solid pharmaceutical |
JPH07100665B2 (en) * | 1987-12-23 | 1995-11-01 | 信越化学工業株式会社 | Method for producing coating agent |
JPH01287021A (en) * | 1988-05-13 | 1989-11-17 | Shin Etsu Chem Co Ltd | Preparation of wax-coated drug preparation |
JP3130058B2 (en) * | 1991-02-15 | 2001-01-31 | 第一製薬株式会社 | Masked granules |
JP2960790B2 (en) * | 1991-03-25 | 1999-10-12 | 塩野義製薬株式会社 | Cephalosporin hydrate crystals for oral administration |
JP3006901B2 (en) * | 1991-03-29 | 2000-02-07 | 塩野義製薬株式会社 | Coated preparation |
JP2987813B2 (en) * | 1993-07-12 | 1999-12-06 | 住友製薬株式会社 | Wax-coated preparation and its production method |
JP3776941B2 (en) * | 1993-12-24 | 2006-05-24 | 塩野義製薬株式会社 | Granules with improved taste and method for producing the same |
WO1997003656A1 (en) * | 1995-07-21 | 1997-02-06 | Daiichi Pharmaceutical Co., Ltd. | Granular preparation and process for producing the same |
DE69732983T2 (en) * | 1996-09-13 | 2006-02-16 | Shionogi & Co., Ltd. | PREPARATION WITH EXTENDED RELEASE USING A THERMAL CONVERSION AND METHOD FOR THE PRODUCTION THEREOF |
JP3466921B2 (en) * | 1998-06-03 | 2003-11-17 | 大塚製薬株式会社 | Taste masking pharmaceutical formulation |
JP2001270821A (en) * | 2000-03-23 | 2001-10-02 | Eisai Co Ltd | Powder medicine having excellent taking easiness |
JP2001302497A (en) * | 2000-04-21 | 2001-10-31 | Eisai Co Ltd | Powdery preparation excellent in miscibility |
JP4300821B2 (en) * | 2002-03-05 | 2009-07-22 | 住友化学株式会社 | Amino acid compounds |
JP3797605B2 (en) * | 2002-03-20 | 2006-07-19 | 旭化成ファーマ株式会社 | Method for producing granular coated preparation |
-
2004
- 2004-10-27 WO PCT/JP2004/015884 patent/WO2005039538A1/en active Application Filing
- 2004-10-27 KR KR1020067007456A patent/KR101168189B1/en active IP Right Grant
- 2004-10-27 CN CNB2004800322353A patent/CN100528233C/en active Active
- 2004-10-27 JP JP2005515009A patent/JP3981134B2/en not_active Expired - Fee Related
- 2004-10-28 TW TW093132662A patent/TWI367767B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20060095564A (en) | 2006-08-31 |
WO2005039538A1 (en) | 2005-05-06 |
CN1874759A (en) | 2006-12-06 |
JP3981134B2 (en) | 2007-09-26 |
TWI367767B (en) | 2012-07-11 |
JPWO2005039538A1 (en) | 2007-11-22 |
KR101168189B1 (en) | 2012-07-25 |
CN100528233C (en) | 2009-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |