CN104491439A - Traditional Chinese medicinal composition for treating infant dental ulcer and preparation method of preparation of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating infant dental ulcer and preparation method of preparation of traditional Chinese medicinal composition Download PDFInfo
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- CN104491439A CN104491439A CN201410820786.1A CN201410820786A CN104491439A CN 104491439 A CN104491439 A CN 104491439A CN 201410820786 A CN201410820786 A CN 201410820786A CN 104491439 A CN104491439 A CN 104491439A
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- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 208000025865 Ulcer Diseases 0.000 title claims abstract description 27
- 231100000397 ulcer Toxicity 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 23
- 239000003814 drug Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 11
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
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- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 1
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- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
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- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
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- 210000005182 tip of the tongue Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for treating infant dental ulcer. The traditional Chinese medicinal composition is prepared from 0.4-0.8 part of borneol, 10-20 parts of bletilla striata, 15-25 parts of gallnut, 6-10 parts of coptis chinensis, 15-25 parts of fossil fragments, 15-25 parts of cuttle bone and 1-3 parts of cutch; the traditional Chinese medicinal composition is in the form of external oil or powder. The traditional Chinese medicinal composition disclosed by the invention is low in medicine dosage, rapid to take effect by external use directly, low in side effect, good in curative effect on infant dental ulcer and suitable for external use for a long term; and the composition is low in raw material cost, simple to operate, good in treatment effect and worth of being popularized and applied.
Description
Technical field
The present invention relates to and be a kind ofly used for the treatment of the Chinese medicine composition of dental ulcer of infant and the preparation method of preparation thereof, belong to tcm field.
Background technology
Oral aphthae in children is the pathological changes that the unhygienic the tip of the tongue that causes in children's oral cavity or oral mucosa occur, and easily causes infantile appetite to suck the breast not smooth.Oral aphthae in children easily occurs in season in spring and autumn, and aphtha, also known as " mouth infections ", refers to and a kind of disease that the shallow table of dispute festers is found in the children's at any age, but more with infant morbidity.Dental ulcer of infant comprises thrush, herpes simplex aphtha, exedens aphtha.Thrush is the invasion and attack owing to there is Candida albicans, forms thrush.There are point-like and strip white scales in cheek mucosa, tongue, gums, palate place, and are fused into sheet gradually in the early stage, not easily wipe away.Herpes simplex rash aphtha occurs slight bright folliculus, shortly very fast diabrosis on the mucosa of oral cavity, tongue and pharyngeal congestion, forms ulcer.Cervical lymph node is also corresponding there is enlargement, has tenderness.Exedens aphtha is that various coccus often invades infant, and cause stomatitis, oral mucosa has obvious hyperemia, with the ulcer differed in size, ulcer has linen pseudomembrane be covered with, children's is pain very, and sialorrhea is more than, dysphoria, refusal feed, often with heating and cervical lymph node enlargement.
The herpetic aphtha of current dental ulcer of infant and exedens aphtha, multiplex 1% tetracaine or XILEI SAN, Zhu Huang San painting mouth.Treatment thrush is commonly used nystatin and is coated with mouth or adjusts Mel to put dispute affected part on the skin with BINGPENG SAN, glycerol, Pulvis Indigo Naturalis.Also by increasing vitamin V B1, VB2, VC, VE or eating green vegetables, fruit more, and note personal oral hygiene, before or after meals is brushed teeth and is gargled.But therapeutic effect differs, feature is that curative effect is slow, and Applicative time is long, DeGrain.Application the present invention treats dental ulcer of infant instant effect, and Applicative time is short, successful, is worthy of popularization.
Summary of the invention
The problem to be solved in the present invention is for above deficiency, provides a kind of and is used for the treatment of the Chinese medicine composition of dental ulcer of infant and the preparation method of preparation thereof.
Technical scheme of the present invention is:
Be used for the treatment of a Chinese medicine composition for dental ulcer of infant, comprise the raw material of following weight portion:
Borneolum Syntheticum 0.4-0.8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Galla Chinensis 15-25 part, Rhizoma Coptidis 6-10 part, Os Draconis 15-25 part, Os Sepiae 15-25 part, catechu 1-3 part.
As technique scheme further preferably, described Chinese medicine composition comprises the raw material of following weight portion:
Borneolum Syntheticum 0.6 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Galla Chinensis 20 parts, Rhizoma Coptidis 8 parts, Os Draconis 20 parts, Os Sepiae 20 parts, 2 parts, catechu.
According to the present invention, a kind of preparation method for the treatment of the Chinese medicinal composition preparation of dental ulcer of infant:
Proportionally get the mixing of each composition of raw material, be ground into 100 object fine powder mix homogeneously and obtain powder.
According to the present invention, a kind of preparation method for the treatment of the Chinese medicinal composition preparation of dental ulcer of infant:
A, the Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Rhizoma Coptidis, Os Draconis, cuttlefish bone meal are broken into 80-100 object fine powder;
B, Borneolum Syntheticum, catechu to be soaked 15 days in linum Oleum sesami, after then making oil, slag be separated, to oils and fats 120 object screen filtrations;
C, by filter after linum Oleum sesami mix according to the above ratio with the fine powder of step a, furnishing scattered paste shape, bottling seal after, carry out sterilization process, obtain external-use oil preparation.
In above raw material:
Borneolum Syntheticum leads to all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
The Pseudobulbus Bletillae (Rhizoma Bletillae) has astringing to arrest bleeding, effect of detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Galla Chinensis is astringed the lung, astringing intestine to stop diarrhea, hemostasis, removing toxic substances.Control chronic cough of deficiency lung, chronic dysentery.Chronic diarrhea, proctoptosis, order antiperspirant, night sweat, seminal emission, has blood in stool, epistaxis, metrorrhagia, traumatic hemorrhage, toxic swelling, furuncle, trichiasis.
Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion acid regurgitation, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle the moon, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Os Draconis subduing hyperactive YANG to ease mental disorders, for hyperactivity of YANG due to deficiency of YIN, irritable, palpitation and insomnia, has a dizzy spell, demented frightened disease such as grade; Forging rear merit restrains astringent or styptic treatment for spontaneous sweating partially, and be used for premature ejaculation of passing out semen, leukorrhagia metrorrhagia, sweating due to debility chronic diarrhea, eczema prurigo, the open sore part is not held back, traumatic hemorrhage etc.In addition, forge and grind external, energy removing dampness sore, controls again eczema flowing water, with the passing of time unhealed.
Os Sepiae is restrained, antacid, hemostasis.For Peptic Ulcers, hyperchlorhydria, spits blood, metrorrhagia, leucorrhea: outer for traumatic hemorrhage, Peptic Ulcers disunion of a specified duration.
Catechu removing dampness promoting tissue regeneration and ulcer healing.For ulcer being unable to heal, eczema, aphtha, falls and flutters the pain of injury, traumatic hemorrhage.
The present invention adopts above technical scheme, compared with prior art, have the following advantages: monarch of the present invention, minister, help, make respectively to execute its effect, there is medication few, direct external instant effect, side effect is little, rather good to dental ulcer of infant curative effect, can long-term taking, and the prices of raw and semifnished materials are cheap, simple to operate, therapeutic effect is good, is worthy of popularization.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: a kind of Chinese medicine composition being used for the treatment of dental ulcer of infant, raw-material weight part is: a kind of Chinese medicine compound being used for the treatment of acne, and raw-material weight part is: Borneolum Syntheticum 0.6 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Galla Chinensis 20 parts, Rhizoma Coptidis 8 parts, Os Draconis 20 parts, Os Sepiae 20 parts, 2 parts, catechu.
Embodiment 2: a kind of Chinese medicine composition being used for the treatment of dental ulcer of infant, raw-material weight part is: Borneolum Syntheticum 0.4 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Galla Chinensis 15 parts, Rhizoma Coptidis 6 parts, Os Draconis 15 parts, Os Sepiae 15 parts, 1 part, catechu.
Embodiment 3: a kind of Chinese medicine composition being used for the treatment of dental ulcer of infant, raw-material weight part is: Borneolum Syntheticum 0.8 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Galla Chinensis 25 parts, Rhizoma Coptidis 10 parts, Os Draconis 25 parts, Os Sepiae 25 parts, 3 parts, catechu.
Embodiment 4: the medicine of above embodiment 1-3 is prepared into different dosage forms according to following steps: powder, external-use oil preparation.：
A, the Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Rhizoma Coptidis, Os Draconis, cuttlefish bone meal are broken into 80-100 object fine powder;
B, Borneolum Syntheticum, catechu to be soaked 15 days in linum Oleum sesami, after then making oil, slag be separated, to oils and fats 120 object screen filtrations;
C, by filter after linum Oleum sesami mix according to the above ratio with the fine powder of step a, furnishing scattered paste shape, bottling seal after, carry out sterilization process, obtain external-use oil preparation.
According to the present invention, a kind of preparation method for the treatment of the Chinese medicinal composition preparation of dental ulcer of infant:
Proportionally get the mixing of each composition of raw material, be ground into 100 object fine powder mix homogeneously and obtain powder.
Contrast test:
Observation of curative effect:
Efficacy assessment standard adopts the criterion of therapeutical effect of " TCM Pediatrics section Illnesses Diagnoses criterion of therapeutical effect " thrush: cure: oral mucosa white scales disappears.Take a turn for the better: oral mucosa white scales reduces.Invalid oral mucosa white scales is unchanged.
Choose 200 routine dental ulcer of infant patients, random selecting 150 example is as treatment group, other 50 examples as a control group, wherein 150 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3,50 routine patients of each treatment group treatment random selecting, treatment group 1 uses the external-use oil preparation of the embodiment of the present invention 1 to treat, and treatment group 2 uses the external-use oil preparation of the embodiment of the present invention 2 to treat, and it is a course for the treatment of that treatment group 3 uses the external-use oil preparation of the embodiment of the present invention 3 to treat .7 day
The patient of matched group adopts XILEI SAN.
Therapeutic outcome is as following table:
As can be seen from above tables of data, treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 1 is higher than all the other treatment groups 2 and treatment group 3, and treatment group 1 prescription is the most effective in sum.
Claims (4)
1. be used for the treatment of a Chinese medicine composition for dental ulcer of infant, be made up of the raw material of following weight portion:
Borneolum Syntheticum 0.4-0.8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Galla Chinensis 15-25 part, Rhizoma Coptidis 6-10 part, Os Draconis 15-25 part, Os Sepiae 15-25 part, catechu 1-3 part.
2. a kind of Chinese medicine composition for the treatment of dental ulcer of infant as claimed in claim 1, be made up of the raw material of following weight portion:
Borneolum Syntheticum 0.6 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Galla Chinensis 20 parts, Rhizoma Coptidis 8 parts, Os Draconis 20 parts, Os Sepiae 20 parts, 2 parts, catechu.
3. preparation is used for the treatment of the method for the Chinese medicine composition of dental ulcer of infant as claimed in claim 1 or 2: comprise the following steps:
A, the Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Rhizoma Coptidis, Os Draconis, cuttlefish bone meal are broken into 80-100 object fine powder;
B, Borneolum Syntheticum, catechu to be soaked 15 days in linum Oleum sesami, after then making oil, slag be separated, to oils and fats 120 object screen filtrations;
C, by filter after linum Oleum sesami mix according to the above ratio with the fine powder of step a, furnishing scattered paste shape, bottling seal after, carry out sterilization process, obtain external-use oil preparation.
4. preparation is used for the treatment of the method for the Chinese medicine composition of dental ulcer of infant as claimed in claim 1 or 2: comprise and proportionally get the mixing of each composition of raw material, be ground into 100 object fine powder mix homogeneously and obtain powder.
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| CN105055817A (en) * | 2015-08-31 | 2015-11-18 | 青岛海之源智能技术有限公司 | Patch for treating oral ulcer and preparation method thereof |
| CN109453211A (en) * | 2018-12-18 | 2019-03-12 | 李风林 | Chinese medicine composition and preparation method thereof for treating canker sore |
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