CN104491439B - A kind of preparation method for being used to treat the Chinese medicine composition and its preparation of dental ulcer of infant - Google Patents

A kind of preparation method for being used to treat the Chinese medicine composition and its preparation of dental ulcer of infant Download PDF

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Publication number
CN104491439B
CN104491439B CN201410820786.1A CN201410820786A CN104491439B CN 104491439 B CN104491439 B CN 104491439B CN 201410820786 A CN201410820786 A CN 201410820786A CN 104491439 B CN104491439 B CN 104491439B
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parts
chinese medicine
infant
medicine composition
preparation
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CN104491439A (en
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于永锋
杨霞
李金文
王照奇
迟增磊
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Shanghai wuseshi Medical Technology Co.,Ltd.
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Suzhou Teng Teng Intellectual Property Advisory Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

A kind of Chinese medicine composition for treating dental ulcer of infant, by：0.4 0.8 parts of borneol, 10 20 parts of the bletilla striata, 15 25 parts of Chinese gall, 6 10 parts of the coptis, 15 25 parts of keel, 15 25 parts of cuttle bone, 13 parts of catechu are made, and the Chinese medicine composition pharmaceutical dosage form is external-use oil preparation, powder.Have that medication is few, and direct external application is quick, Small side effects, rather good to dental ulcer of infant curative effect using the present invention, can long-term external application, and the prices of raw materials are cheap, and simple to operate, therapeutic effect is good, is worthy of popularization.

Description

A kind of preparation for being used to treat the Chinese medicine composition and its preparation of dental ulcer of infant Method
Technical field
The present invention relates to a kind of preparation method for being used to treat the Chinese medicine composition and its preparation of dental ulcer of infant, belong to Tcm field.
Background technology
Oral aphthae in children be children oral cavity it is unhygienic caused by the lesion that occurs of the tip of the tongue or oral mucosa, easily cause infantile appetite Suck the breast not smooth.Oral aphthae in children easily occurs to be also known as " mouth ulcer " in season in spring and autumn, aphtha, refer to a kind of disease that dispute superficial is festered, The children at any age are found in, but it is more with infant's morbidity.Dental ulcer of infant includes thrush, herpes simplex mouth Sore, exedens aphtha.Thrush is due to that the invasion and attack of Candida albicans occur, and forms thrush.In the early stage in cheek mucous membrane, tongue, There are point-like and strip to consider to be worth doing in vain at gums, palate, and be gradually fused into sheet, be not easy to wipe away.Herpe simplex rash aphtha be Occur slight bright folliculus on the mucous membrane in oral cavity, tongue and congestion of throat, shortly diabrosis quickly, form ulcer.Cervical lymph Also accordingly there is enlargement in knot, there is tenderness.Exedens aphtha is that various coccuses often invade infant, causes stomatitis, mucous membrane of mouth There is obvious hyperemia, with the ulcer to differ in size, there is linen pseudomembrane to be covered with ulcer, children's very pain, salivation Incessantly, have the fidgets, refusal feed, be often accompanied by heating and cervical lymph node enlargement.
The herpetic aphtha of dental ulcer of infant and exedens aphtha at present, use 1% dicaine or xilei san, Zhu Huang San Apply mouth.Treatment thrush often applies mouth with nystatin or adjusts honey to put dispute affected part on the skin with Bingpeng San, glycerine, qingdai powder.Also by Increase vitamin V B1, VB2, VC, VE or eat green vegetables, fruit more, and pay attention to personal oral hygiene, and before or after meals, which are brushed teeth, to be gargled Mouthful.But therapeutic effect differs, feature is that curative effect is slow, application time length, DeGrain.Burst using present invention treatment children oral cavity Ulcer is quick, and application time is short, positive effect, is worthy of popularization.
The content of the invention
The problem to be solved in the present invention is the deficiency for more than, there is provided a kind of Chinese medicine group for being used to treat dental ulcer of infant The preparation method of compound and its preparation.
The technical scheme is that：
A kind of Chinese medicine composition for being used to treat dental ulcer of infant, include the raw material of following parts by weight：
Borneol 0.4-0.8 parts, bletilla striata 10-20 parts, Chinese gall 15-25 parts, coptis 6-10 parts, keel 15-25 parts, cuttle bone 15-25 parts, catechu 1-3 parts.
As the further preferred of above-mentioned technical proposal, the Chinese medicine composition includes the raw material of following parts by weight：
0.6 part of borneol, 15 parts of the bletilla striata, 20 parts of Chinese gall, 8 parts of the coptis, 20 parts of keel, 20 parts of cuttle bone, 2 parts of catechu.
According to the present invention, a kind of preparation method for the Chinese medicinal composition preparation for treating dental ulcer of infant：
Proportionally take each composition of raw material to mix, be ground into that 100 targeted fine powders are well mixed to obtain powder.
According to the present invention, a kind of preparation method for the Chinese medicinal composition preparation for treating dental ulcer of infant：
A, the bletilla striata, Chinese gall, the coptis, keel, cuttlefish bone meal are broken into 80-100 targeted fine powders；
B, borneol, catechu are soaked 15 days in flax sesame oil, after then making oil, slag separation, the sieve to grease with 120 mesh Net filtration；
C, the flax sesame oil after filtering is mixed according to the above ratio with step a fine powder, is tuned into scattered paste shape, bottling sealing Afterwards, sterilization processing is carried out, produces external-use oil preparation.
In above raw material：
Borneol leads to all keys, dissipates stagnated fire, removes screen improving eyesight, swelling and pain relieving.Apoplexy lockjaw is controlled, pyreticosis coma, frightened epilepsy phlegm fan is gas-tight Deafness, larynx numbness, aphtha, tympanitis, carbuncle swells, hemorrhoid, mesh also screen film, enterobiasis.
The bletilla striata has the effect of astringing to arrest bleeding, detumescence and promoting granulation.Spitted blood for hemoptysis, traumatism and bleeding, sore swollen toxin, skin chap Split；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Chinese gall is astringed the lung, puckery intestines, is stopped blooding, removing toxic substances.Control chronic cough of deficiency lung, protracted dysentery.Chronic diarrhea, prolapse of the anus, mesh sweat, night sweat, seminal emission, just Blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatism and bleeding, pyogenic infections, boil, trichiasis.
Coptis heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, vomit, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, Dysphoria and insomnia, blood-head tells nosebleed, hot eyes acid regurgitation, toothache, quench one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.Prepared RHIZOMA COPTIDIS with vino is apt to The clear part of the body cavity above the diaphragm housing the heart and lungs is burning hot.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.Mutually tied for fever and chills, damp and hot middle the moon, feeling of fullness vomiting.Cornel The easypro liver anti-vomiting of the coptis.For liver-stomach disharmony, acid regurgitation is vomitted.
Keel checking exuberant yang to ease mental strain, for hyperactivity of yang due to yin deficiency, irritable, palpitation and insomnia, have a dizzy spell, demented frightened grade disease；After forging Work(is restrained astringent or styptic treatment for spontaneous sweating partially, is used for premature ejaculation of passing out semen, is not held back with lower uterine bleeding, abnormal sweating chronic diarrhea, wet sore pruigo, the open sore part, traumatism and bleeding etc..This Outside, forge and grind external application, energy hygroscopic sore, control wet sore flowing water, with the passing of time unhealed again.
Cuttle bone is restrained, relieving haperacidity, hemostasis.For canker, hyperhydrochloria, spit blood, uterine bleeding, leukorrhea：Go out outside for wound Blood, the long disunion of canker.
Catechu hygroscopic myogenic sore.For unhealing ulcer, eczema, aphtha, the pain of injury caused by falling and tumbling, traumatism and bleeding.
The present invention uses above technical scheme, compared with prior art, have advantages below：Monarch of the present invention, minister, help, make Its effect is respectively applied, few with medication, direct external application is quick, Small side effects, rather good to dental ulcer of infant curative effect, can take for a long time With, and the prices of raw materials are cheap, simple to operate, therapeutic effect is good, is worthy of popularization.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1：A kind of Chinese medicine composition for being used to treat dental ulcer of infant, raw-material weight part are：One kind is used for The Chinese medicine compound of acne is treated, raw-material weight part is：0.6 part of borneol, 15 parts of the bletilla striata, 20 parts of Chinese gall, 8 parts of the coptis, dragon 20 parts of bone, 20 parts of cuttle bone, 2 parts of catechu.
Embodiment 2：A kind of Chinese medicine composition for being used to treat dental ulcer of infant, raw-material weight part are：Borneol 0.4 Part, 10 parts of the bletilla striata, 15 parts of Chinese gall, 6 parts of the coptis, 15 parts of keel, 15 parts of cuttle bone, 1 part of catechu.
Embodiment 3：A kind of Chinese medicine composition for being used to treat dental ulcer of infant, raw-material weight part are：Borneol 0.8 Part, 20 parts of the bletilla striata, 25 parts of Chinese gall, 10 parts of the coptis, 25 parts of keel, 25 parts of cuttle bone, 3 parts of catechu.
Embodiment 4：Above example 1-3 medicine is prepared into different formulations according to following steps：Powder, external application oil Agent.：
A, the bletilla striata, Chinese gall, the coptis, keel, cuttlefish bone meal are broken into 80-100 targeted fine powders；
B, borneol, catechu are soaked 15 days in flax sesame oil, after then making oil, slag separation, the sieve to grease with 120 mesh Net filtration；
C, the flax sesame oil after filtering is mixed according to the above ratio with step a fine powder, is tuned into scattered paste shape, bottling sealing Afterwards, sterilization processing is carried out, produces external-use oil preparation.
According to the present invention, a kind of preparation method for the Chinese medicinal composition preparation for treating dental ulcer of infant：
Proportionally take each composition of raw material to mix, be ground into that 100 targeted fine powders are well mixed to obtain powder.
Contrast test：
Observation of curative effect：
Efficacy assessment standard uses《TCM Pediatrics section Illnesses Diagnoses criterion of therapeutical effect》The effect of thrush standard：Cure：Mouthful Transmucosal considers disappearance to be worth doing in vain.Take a turn for the better：Oral mucosa considers reduction to be worth doing in vain.Invalid oral mucosa is considered to be worth doing unchanged in vain.
Choose 200 dental ulcer of infant patients, randomly select 150 and be used as treatment group, in addition 50 as a control group, Wherein 150 patients are divided into treatment group 1, treatment group 2 and treatment group 3,50 patients that each treatment group's treatment randomly selects, control Treatment group 1 is treated using the external-use oil preparation of the embodiment of the present invention 1, and treatment group 2 is entered using the external-use oil preparation of the embodiment of the present invention 2 Row treatment, treatment group 3 are a course for the treatment of using the external-use oil preparation treatment .7 days of the embodiment of the present invention 3
The patient of control group uses xilei san.
Treatment results such as following table：
Treatment group's effective percentage cure rate is can be seen that apparently higher than control group, the cure rate for the treatment of group 1 from data above table Effective percentage is higher than remaining treatment group 2 and treatment group 3, and the prescription for the treatment of group 1 is maximally efficient in summary.

Claims (3)

1. a kind of Chinese medicine composition for being used to treat dental ulcer of infant, it is characterized in that：The Chinese medicine composition is by following weight The raw material of part are made：
0.6 part of borneol, 15 parts of the bletilla striata, 20 parts of Chinese gall, 8 parts of the coptis, 20 parts of keel, 20 parts of cuttle bone, 2 parts of catechu.
2. prepare the method for being used to treat the Chinese medicine composition of dental ulcer of infant as claimed in claim 1：The Chinese medicine group The preparation method of compound comprises the following steps：
A, the bletilla striata, Chinese gall, the coptis, keel, cuttlefish bone meal are broken into 80-100 targeted fine powders；
B, borneol, catechu are soaked 15 days in flax sesame oil, after then making oil, slag separation, to the screen cloth mistake of 120 mesh of grease Filter；
C, the flax sesame oil after filtering is mixed according to the above ratio with step a fine powder, is tuned into scattered paste shape, after bottling sealing, enters The processing of row sterilization, produces external-use oil preparation.
3. prepare the method for being used to treat the Chinese medicine composition of dental ulcer of infant as claimed in claim 1：Proportionally take The mixing of each composition of raw material, is ground into that 100 targeted fine powders are well mixed to obtain powder.
CN201410820786.1A 2014-12-19 2014-12-19 A kind of preparation method for being used to treat the Chinese medicine composition and its preparation of dental ulcer of infant Active CN104491439B (en)

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Publication number Priority date Publication date Assignee Title
CN105055817A (en) * 2015-08-31 2015-11-18 青岛海之源智能技术有限公司 Patch for treating oral ulcer and preparation method thereof
CN109453211A (en) * 2018-12-18 2019-03-12 李风林 Chinese medicine composition and preparation method thereof for treating canker sore

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CN102579655A (en) * 2012-03-27 2012-07-18 李文汉 Externally applied traditional Chinese medicine preparation for treating oral ulcer
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CN102579655A (en) * 2012-03-27 2012-07-18 李文汉 Externally applied traditional Chinese medicine preparation for treating oral ulcer
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Inventor after: Yu Yongfeng

Inventor after: Yang Xia

Inventor after: Li Jinwen

Inventor after: Wang Zhaoqi

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Inventor before: Wang Jianling

Inventor before: Zhang Zhongping

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Address after: 234000 Anhui city in Suzhou Province, the Milky Way two road in the north east of Conrad Qing Yun Lu Jinxiu Jiangnan (West) B1 floor, room 1602

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Address before: The third people's Hospital of Haiyang City, Shandong province 265100 No. 3 Yantai Haiyang Sea Road

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