CN100497333C - 用于治疗神经紊乱的二氢苯并二氮杂-2-酮衍生物 - Google Patents

用于治疗神经紊乱的二氢苯并二氮杂-2-酮衍生物 Download PDF

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Publication number
CN100497333C
CN100497333C CNB038065452A CN03806545A CN100497333C CN 100497333 C CN100497333 C CN 100497333C CN B038065452 A CNB038065452 A CN B038065452A CN 03806545 A CN03806545 A CN 03806545A CN 100497333 C CN100497333 C CN 100497333C
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CN
China
Prior art keywords
phenyl
pyridin
methyl
trifluoromethyl
dihydrobenzo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038065452A
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English (en)
Chinese (zh)
Other versions
CN1633430A (zh
Inventor
G·亚当
E·格斯奇
J·维希曼
T·J·沃特林
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB038065452A 2002-02-06 2003-01-28 用于治疗神经紊乱的二氢苯并二氮杂-2-酮衍生物 Expired - Fee Related CN100497333C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02002012.9 2002-02-06
EP02002012 2002-02-06

Publications (2)

Publication Number Publication Date
CN1633430A CN1633430A (zh) 2005-06-29
CN100497333C true CN100497333C (zh) 2009-06-10

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CNB038065452A Expired - Fee Related CN100497333C (zh) 2002-02-06 2003-01-28 用于治疗神经紊乱的二氢苯并二氮杂-2-酮衍生物

Country Status (30)

Country Link
US (1) US6949542B2 (enExample)
EP (1) EP1474416B1 (enExample)
JP (1) JP4077411B2 (enExample)
KR (1) KR20040081486A (enExample)
CN (1) CN100497333C (enExample)
AR (1) AR038481A1 (enExample)
AT (1) ATE374196T1 (enExample)
AU (1) AU2003205695B8 (enExample)
BR (1) BR0307474A (enExample)
CA (1) CA2474219C (enExample)
DE (1) DE60316538T2 (enExample)
DK (1) DK1474416T3 (enExample)
ES (1) ES2294264T3 (enExample)
GT (1) GT200300028A (enExample)
HR (1) HRP20040678A2 (enExample)
IL (1) IL163102A (enExample)
MX (1) MXPA04007516A (enExample)
MY (1) MY176608A (enExample)
NO (1) NO327697B1 (enExample)
NZ (1) NZ534122A (enExample)
PA (1) PA8565901A1 (enExample)
PE (1) PE20031011A1 (enExample)
PL (1) PL372425A1 (enExample)
PT (1) PT1474416E (enExample)
RU (1) RU2315764C2 (enExample)
SI (1) SI1474416T1 (enExample)
TW (1) TWI326599B (enExample)
UY (1) UY27654A1 (enExample)
WO (1) WO2003066623A1 (enExample)
ZA (1) ZA200406032B (enExample)

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JP5204232B2 (ja) 2007-08-27 2013-06-05 エフ．ホフマン−ラ ロシュ アーゲー Ｆｘｒアゴニストとして使用されるベンゾイミダゾール誘導体
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
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EA017648B1 (ru) 2007-09-14 2013-02-28 Орто-Макнейл-Янссен Фармасьютикалз, Инк. 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
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WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
HRP20131122T1 (hr) 2009-05-12 2013-12-20 Janssen Pharmaceuticals, Inc. Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
WO2011021676A1 (ja) 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法
NZ601547A (en) 2010-01-25 2014-04-30 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP5852664B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
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SG2014012926A (en) 2011-08-30 2014-06-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2013033068A1 (en) 2011-08-30 2013-03-07 Stephen Martin Courtney Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EP2877444B1 (en) 2012-07-27 2020-09-02 The Broad Institute, Inc. Inhibitors of histone deacetylase
HK1206615A1 (en) 2012-10-23 2016-01-15 霍夫曼-拉罗奇有限公司 Mglu2/3 antagonists for the treatment of autistic disorders
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
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Also Published As

Publication number Publication date
SI1474416T1 (sl) 2008-02-29
HK1078858A1 (zh) 2006-03-24
AU2003205695B2 (en) 2008-04-03
EP1474416B1 (en) 2007-09-26
KR20040081486A (ko) 2004-09-21
AU2003205695A1 (en) 2003-09-02
WO2003066623A1 (en) 2003-08-14
NO327697B1 (no) 2009-09-14
MY176608A (en) 2020-08-18
AR038481A1 (es) 2005-01-19
HRP20040678A2 (en) 2005-10-31
TW200302730A (en) 2003-08-16
BR0307474A (pt) 2004-11-09
AU2003205695B8 (en) 2008-05-01
CA2474219C (en) 2010-04-13
MXPA04007516A (es) 2004-11-10
PL372425A1 (en) 2005-07-25
ZA200406032B (en) 2005-10-12
NZ534122A (en) 2006-12-22
RU2004126945A (ru) 2005-06-27
ES2294264T3 (es) 2008-04-01
PT1474416E (pt) 2007-12-27
NO20043237L (no) 2004-08-02
TWI326599B (en) 2010-07-01
PE20031011A1 (es) 2003-11-29
IL163102A (en) 2011-07-31
RU2315764C2 (ru) 2008-01-27
UY27654A1 (es) 2003-08-29
JP2005522440A (ja) 2005-07-28
DE60316538T2 (de) 2008-08-21
US6949542B2 (en) 2005-09-27
DK1474416T3 (da) 2008-01-14
US20030166639A1 (en) 2003-09-04
PA8565901A1 (es) 2003-09-05
DE60316538D1 (de) 2007-11-08
ATE374196T1 (de) 2007-10-15
CA2474219A1 (en) 2003-08-14
GT200300028A (es) 2004-06-11
CN1633430A (zh) 2005-06-29
EP1474416A1 (en) 2004-11-10
JP4077411B2 (ja) 2008-04-16

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