JP4077411B2 - ジヒドロベンゾジアゼピン−２−オン誘導体ｉｉｉ - Google Patents

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Publication number

JP4077411B2

JP4077411B2 JP2003565996A JP2003565996A JP4077411B2 JP 4077411 B2 JP4077411 B2 JP 4077411B2 JP 2003565996 A JP2003565996 A JP 2003565996A JP 2003565996 A JP2003565996 A JP 2003565996A JP 4077411 B2 JP4077411 B2 JP 4077411B2

Authority

JP

Japan

Prior art keywords

phenyl

pyridin

mmol

methyl

butyl ester

Prior art date

2002-02-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 238000000034 method Methods 0.000 claims description 786
• 150000001875 compounds Chemical class 0.000 claims description 629
• -1 -NR'R " Chemical group 0.000 claims description 371
• 125000000217 alkyl group Chemical group 0.000 claims description 78
• 125000003545 alkoxy group Chemical group 0.000 claims description 52
• 239000001257 hydrogen Substances 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 31
• 125000003282 alkyl amino group Chemical group 0.000 claims description 30
• 229910052736 halogen Inorganic materials 0.000 claims description 30
• 238000006243 chemical reaction Methods 0.000 claims description 29
• 150000002431 hydrogen Chemical class 0.000 claims description 26
• 150000002367 halogens Chemical class 0.000 claims description 25
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 22
• 150000003839 salts Chemical class 0.000 claims description 22
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 19
• 238000002360 preparation method Methods 0.000 claims description 19
• 125000001424 substituent group Chemical group 0.000 claims description 19
• 125000001153 fluoro group Chemical group F* 0.000 claims description 18
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
• 125000004414 alkyl thio group Chemical group 0.000 claims description 12
• 239000003814 drug Substances 0.000 claims description 11
• 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims description 10
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
• 125000004076 pyridyl group Chemical group 0.000 claims description 8
• 239000002253 acid Substances 0.000 claims description 7
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 7
• 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims description 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
• 230000001154 acute effect Effects 0.000 claims description 6
• 230000001684 chronic effect Effects 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 230000002265 prevention Effects 0.000 claims description 6
• ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims description 6
• 208000012902 Nervous system disease Diseases 0.000 claims description 5
• 208000025966 Neurological disease Diseases 0.000 claims description 5
• 208000028017 Psychotic disease Diseases 0.000 claims description 5
• 125000003277 amino group Chemical group 0.000 claims description 5
• XFCBAUSXXGLTIP-UHFFFAOYSA-N 4-(3-pyridin-3-ylphenyl)-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC(F)(F)F)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 XFCBAUSXXGLTIP-UHFFFAOYSA-N 0.000 claims description 4
• QWFYXUVFCJKYON-UHFFFAOYSA-N 8-chloro-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(Cl)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QWFYXUVFCJKYON-UHFFFAOYSA-N 0.000 claims description 4
• RRJHUDLALLDKRL-UHFFFAOYSA-N 8-chloro-4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-methyl-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C)C=C3N=2)=C1 RRJHUDLALLDKRL-UHFFFAOYSA-N 0.000 claims description 4
• CWZIXKLALYDKHJ-UHFFFAOYSA-N 8-chloro-7-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C)C=C3N=2)=C1 CWZIXKLALYDKHJ-UHFFFAOYSA-N 0.000 claims description 4
• 208000024827 Alzheimer disease Diseases 0.000 claims description 4
• 208000028698 Cognitive impairment Diseases 0.000 claims description 4
• 208000010877 cognitive disease Diseases 0.000 claims description 4
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 4
• 206010027175 memory impairment Diseases 0.000 claims description 4
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
• LYTVXCQQTLUEQR-UHFFFAOYSA-N ro4491533 Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 LYTVXCQQTLUEQR-UHFFFAOYSA-N 0.000 claims description 4
• 201000000980 schizophrenia Diseases 0.000 claims description 4
• XTQHVAXLUHGINO-UHFFFAOYSA-N 4-(3-pyridin-3-ylphenyl)-7-(2,2,2-trifluoroethoxy)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C2=CC(OCC(F)(F)F)=CC=C2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 XTQHVAXLUHGINO-UHFFFAOYSA-N 0.000 claims description 3
• NBKPYZLFZCYJJE-UHFFFAOYSA-N 4-(3-pyridin-4-ylphenyl)-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC(F)(F)F)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 NBKPYZLFZCYJJE-UHFFFAOYSA-N 0.000 claims description 3
• JYTRCRINABXASK-UHFFFAOYSA-N 4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(C(F)(F)F)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 JYTRCRINABXASK-UHFFFAOYSA-N 0.000 claims description 3
• PXNOUTUNFINTTA-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-(2,2,2-trifluoroethoxy)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(OCC(F)(F)F)C=C3N=2)C(F)(F)F)=C1 PXNOUTUNFINTTA-UHFFFAOYSA-N 0.000 claims description 3
• GGCAJGPNBPIIQA-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-ethoxy-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC(C)=NC(C)=C1 GGCAJGPNBPIIQA-UHFFFAOYSA-N 0.000 claims description 3
• PQWNWLVSPGJPAF-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)C(F)(F)F)=C1 PQWNWLVSPGJPAF-UHFFFAOYSA-N 0.000 claims description 3
• DFWDFOZNVALGES-UHFFFAOYSA-N 4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)C(F)(F)F)=C1 DFWDFOZNVALGES-UHFFFAOYSA-N 0.000 claims description 3
• CUBHTWLIWFXCKK-UHFFFAOYSA-N 7,8-dichloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(Cl)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 CUBHTWLIWFXCKK-UHFFFAOYSA-N 0.000 claims description 3
• VMEZSFFCHLCBBK-UHFFFAOYSA-N 7,8-dichloro-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(Cl)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 VMEZSFFCHLCBBK-UHFFFAOYSA-N 0.000 claims description 3
• HXTQTHUBKDBECJ-UHFFFAOYSA-N 7,8-dichloro-4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(Cl)C=C3N=2)=C1 HXTQTHUBKDBECJ-UHFFFAOYSA-N 0.000 claims description 3
• CMLVJJVYIVBZNH-UHFFFAOYSA-N 7,8-dichloro-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(Cl)C=C3N=2)=C1 CMLVJJVYIVBZNH-UHFFFAOYSA-N 0.000 claims description 3
• DZCFLWXSUXKAJI-UHFFFAOYSA-N 7-(dimethylamino)-4-(3-pyridin-3-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 DZCFLWXSUXKAJI-UHFFFAOYSA-N 0.000 claims description 3
• YQKASQGOPRPMLH-UHFFFAOYSA-N 7-(dimethylamino)-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 YQKASQGOPRPMLH-UHFFFAOYSA-N 0.000 claims description 3
• CCOJJDFNFUBNKN-UHFFFAOYSA-N 7-(dimethylamino)-4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC(C)=C1 CCOJJDFNFUBNKN-UHFFFAOYSA-N 0.000 claims description 3
• GXQISOFEZQYHPI-UHFFFAOYSA-N 7-[methyl(propyl)amino]-4-(3-pyrazin-2-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(N(C)CCC)=CC=2N=C1C(C=1)=CC=CC=1C1=CN=CC=N1 GXQISOFEZQYHPI-UHFFFAOYSA-N 0.000 claims description 3
• OPUCFSUMZCYZKN-UHFFFAOYSA-N 7-chloro-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(Cl)C(C(F)(F)F)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 OPUCFSUMZCYZKN-UHFFFAOYSA-N 0.000 claims description 3
• AHDAHZZDQMCLJT-UHFFFAOYSA-N 7-chloro-4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(Cl)C=C3N=2)C(F)(F)F)=C1 AHDAHZZDQMCLJT-UHFFFAOYSA-N 0.000 claims description 3
• QFBDRSIFOKYSDY-UHFFFAOYSA-N 7-ethoxy-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(OCC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QFBDRSIFOKYSDY-UHFFFAOYSA-N 0.000 claims description 3
• JNFNUQBEVWFFJC-UHFFFAOYSA-N 7-methyl-4-(3-pyrazin-2-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CN=CC=N1 JNFNUQBEVWFFJC-UHFFFAOYSA-N 0.000 claims description 3
• OQTSPIQICMTNOL-UHFFFAOYSA-N 7-methyl-4-(3-pyridazin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NN=C1 OQTSPIQICMTNOL-UHFFFAOYSA-N 0.000 claims description 3
• ZYGZDPKEZBLAHD-UHFFFAOYSA-N 7-methyl-4-(3-pyridin-4-ylphenyl)-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 ZYGZDPKEZBLAHD-UHFFFAOYSA-N 0.000 claims description 3
• ZTMGYWMZJBHXBD-UHFFFAOYSA-N 7-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 ZTMGYWMZJBHXBD-UHFFFAOYSA-N 0.000 claims description 3
• NZWUYDARLBVUAZ-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=NC=CC=3)C2=C1 NZWUYDARLBVUAZ-UHFFFAOYSA-N 0.000 claims description 3
• DEOUQGPUEWWMNC-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=CN=CC=3)C2=C1 DEOUQGPUEWWMNC-UHFFFAOYSA-N 0.000 claims description 3
• VBTRNVBPGJSEAM-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-(3-pyrimidin-5-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound FC1=CC=CC=C1C1=CC=C(N=C(CC(=O)N2)C=3C=C(C=CC=3)C=3C=NC=NC=3)C2=C1 VBTRNVBPGJSEAM-UHFFFAOYSA-N 0.000 claims description 3
• QHWRKFWOOXWYMW-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-[3-(2-methylpyridin-3-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC=CC=C1C1=CC=CC(C=2CC(=O)NC3=CC(=CC=C3N=2)C=2C(=CC=CC=2)F)=C1 QHWRKFWOOXWYMW-UHFFFAOYSA-N 0.000 claims description 3
• LKVQKLAWCNGKSL-UHFFFAOYSA-N 8-(2-fluorophenyl)-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=CC=C3N=2)C=2C(=CC=CC=2)F)=C1 LKVQKLAWCNGKSL-UHFFFAOYSA-N 0.000 claims description 3
• PQMAJJWGJPOQQE-UHFFFAOYSA-N 8-chloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC2=CC(Cl)=CC=C2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 PQMAJJWGJPOQQE-UHFFFAOYSA-N 0.000 claims description 3
• JLXAVOQTRVUYKG-UHFFFAOYSA-N 8-chloro-4-[3-(2-methylpyridin-3-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC=CC=C1C1=CC=CC(C=2CC(=O)NC3=CC(Cl)=CC=C3N=2)=C1 JLXAVOQTRVUYKG-UHFFFAOYSA-N 0.000 claims description 3
• PRPOBZJPAWDSGQ-UHFFFAOYSA-N 8-chloro-4-[3-(2-methylpyridin-4-yl)phenyl]-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(Cl)=C(C=C3N=2)C(F)(F)F)=C1 PRPOBZJPAWDSGQ-UHFFFAOYSA-N 0.000 claims description 3
• HRSCABPISYBZJE-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyrazin-2-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CN=CC=N1 HRSCABPISYBZJE-UHFFFAOYSA-N 0.000 claims description 3
• ITPMBZMJFFOBBB-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridazin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NN=C1 ITPMBZMJFFOBBB-UHFFFAOYSA-N 0.000 claims description 3
• ODSWASRHKDESDR-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridin-3-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=CN=C1 ODSWASRHKDESDR-UHFFFAOYSA-N 0.000 claims description 3
• QPHSKVNFGZIDPN-UHFFFAOYSA-N 8-chloro-7-methyl-4-(3-pyridin-4-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(Cl)C(C)=CC=2N=C1C(C=1)=CC=CC=1C1=CC=NC=C1 QPHSKVNFGZIDPN-UHFFFAOYSA-N 0.000 claims description 3
• YJSYRZKLIDMQGG-UHFFFAOYSA-N 8-fluoro-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(F)=CC=C3N=2)=C1 YJSYRZKLIDMQGG-UHFFFAOYSA-N 0.000 claims description 3
• YYEKPNNSPXLPJC-UHFFFAOYSA-N 8-methyl-4-(3-pyridin-3-ylphenyl)-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(C(F)(F)F)C(C)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=CN=C1 YYEKPNNSPXLPJC-UHFFFAOYSA-N 0.000 claims description 3
• QRDOMCFVXRYHRK-UHFFFAOYSA-N 8-methyl-4-(3-pyridin-4-ylphenyl)-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound N=1C=2C=C(C(F)(F)F)C(C)=CC=2NC(=O)CC=1C(C=1)=CC=CC=1C1=CC=NC=C1 QRDOMCFVXRYHRK-UHFFFAOYSA-N 0.000 claims description 3
• YCFKJJCPSFWCPF-UHFFFAOYSA-N 8-methyl-4-[3-(2-methylpyridin-4-yl)phenyl]-7-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(C)=C(C=C3N=2)C(F)(F)F)=C1 YCFKJJCPSFWCPF-UHFFFAOYSA-N 0.000 claims description 3
• 125000003342 alkenyl group Chemical group 0.000 claims description 3
• 230000008569 process Effects 0.000 claims description 3
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
• UVNQIBJKZJJBQK-UHFFFAOYSA-N 4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-ethyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound C1C(=O)NC=2C=C(C(F)(F)F)C(CC)=CC=2N=C1C(C=1)=CC=CC=1C1=CC(C)=NC(C)=C1 UVNQIBJKZJJBQK-UHFFFAOYSA-N 0.000 claims description 2
• AFSJGBXRHLXBHV-UHFFFAOYSA-N 4-[3-(2-ethyl-6-methylpyridin-4-yl)phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one Chemical compound CC1=NC(CC)=CC(C=2C=C(C=CC=2)C=2CC(=O)NC3=CC(=C(C)C=C3N=2)C(F)(F)F)=C1 AFSJGBXRHLXBHV-UHFFFAOYSA-N 0.000 claims description 2
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• OYPDZZQTVXZYBI-UHFFFAOYSA-N methyl 3-(6-methylpyrimidin-4-yl)benzoate Chemical compound COC(=O)C1=CC=CC(C=2N=CN=C(C)C=2)=C1 OYPDZZQTVXZYBI-UHFFFAOYSA-N 0.000 description 1
• MEXYDEMLZDRPMD-UHFFFAOYSA-N methyl 3-[2-(2-methoxyethylamino)-6-methylpyrimidin-4-yl]benzoate Chemical compound COCCNC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)OC)=N1 MEXYDEMLZDRPMD-UHFFFAOYSA-N 0.000 description 1
• WFHIGNDVSVSHMV-UHFFFAOYSA-N methyl 3-[2-(dimethylamino)-6-methylpyrimidin-4-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2N=C(N=C(C)C=2)N(C)C)=C1 WFHIGNDVSVSHMV-UHFFFAOYSA-N 0.000 description 1
• COZADSLTQGYNMK-UHFFFAOYSA-N methyl 3-[2-(hydroxymethyl)-6-methylpyridin-4-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2C=C(CO)N=C(C)C=2)=C1 COZADSLTQGYNMK-UHFFFAOYSA-N 0.000 description 1
• DPKFMXPSGWFMNF-UHFFFAOYSA-N methyl 3-[2-(hydroxymethyl)pyridin-4-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2C=C(CO)N=CC=2)=C1 DPKFMXPSGWFMNF-UHFFFAOYSA-N 0.000 description 1
• BQEJDUQRPNKRJQ-UHFFFAOYSA-N methyl 3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=C(C)C=2)=C1 BQEJDUQRPNKRJQ-UHFFFAOYSA-N 0.000 description 1
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• YSDVGWJITRIKNE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,3-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=C(C)N=CC=2)C)=C1 YSDVGWJITRIKNE-UHFFFAOYSA-N 0.000 description 1
• SHCBBNACISWIOS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,5-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CN=C(C)C=2)C)=C1 SHCBBNACISWIOS-UHFFFAOYSA-N 0.000 description 1
• ITQYDISHXKKJNQ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(OC(F)(F)F)C=2)NC(=O)OC(C)(C)C)=C1 ITQYDISHXKKJNQ-UHFFFAOYSA-N 0.000 description 1
• ADNYTMZEEXURPR-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 ADNYTMZEEXURPR-UHFFFAOYSA-N 0.000 description 1
• ONZDDUPLYUFADF-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2-methoxyethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCOC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 ONZDDUPLYUFADF-UHFFFAOYSA-N 0.000 description 1
• ARXSKLDKTLSYEX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-[methyl(2-methylpropyl)amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 ARXSKLDKTLSYEX-UHFFFAOYSA-N 0.000 description 1
• MJULAPWOLIRZFS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-[methyl(propan-2-yl)amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 MJULAPWOLIRZFS-UHFFFAOYSA-N 0.000 description 1
• VQGUPJPJBQAWHS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-[methyl(propyl)amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 VQGUPJPJBQAWHS-UHFFFAOYSA-N 0.000 description 1
• URMNOGACKNTAIZ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethenyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C=C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 URMNOGACKNTAIZ-UHFFFAOYSA-N 0.000 description 1
• PRIQPPQWJSNNPD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 PRIQPPQWJSNNPD-UHFFFAOYSA-N 0.000 description 1
• ZMCHBQKUCNLDDW-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 ZMCHBQKUCNLDDW-UHFFFAOYSA-N 0.000 description 1
• PVSZOCGBAWHAOD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-fluoro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PVSZOCGBAWHAOD-UHFFFAOYSA-N 0.000 description 1
• ZWLHGKFMYGHYNK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-morpholin-4-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N2CCOCC2)NC(=O)OC(C)(C)C)=C1 ZWLHGKFMYGHYNK-UHFFFAOYSA-N 0.000 description 1
• XHHBAOSGAUPSDD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-propoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 XHHBAOSGAUPSDD-UHFFFAOYSA-N 0.000 description 1
• KYYZXADPWOVRAU-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 KYYZXADPWOVRAU-UHFFFAOYSA-N 0.000 description 1
• TWOFNZFDPFUQIH-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N2CCCC2)NC(=O)OC(C)(C)C)=C1 TWOFNZFDPFUQIH-UHFFFAOYSA-N 0.000 description 1
• KXCFMSUZRSHZME-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 KXCFMSUZRSHZME-UHFFFAOYSA-N 0.000 description 1
• IMWFWFGJLJXNCI-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2-methoxyethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCOC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 IMWFWFGJLJXNCI-UHFFFAOYSA-N 0.000 description 1
• MOXGNNRFYODCFV-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 MOXGNNRFYODCFV-UHFFFAOYSA-N 0.000 description 1
• ZDZISTWDPNTCIK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=C(C(F)(F)F)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 ZDZISTWDPNTCIK-UHFFFAOYSA-N 0.000 description 1
• HRNNPMBTWZAJHP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopentylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CCCC2)=C1 HRNNPMBTWZAJHP-UHFFFAOYSA-N 0.000 description 1
• OTOBVCANHWNUIC-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopentylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CCCC2)=C1 OTOBVCANHWNUIC-UHFFFAOYSA-N 0.000 description 1
• WGYATJSGDKWLIC-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopentylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CCCC2)=C1 WGYATJSGDKWLIC-UHFFFAOYSA-N 0.000 description 1
• KOMUZAJRDTVAKO-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopentylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CCCC2)=C1 KOMUZAJRDTVAKO-UHFFFAOYSA-N 0.000 description 1
• AZISKSMZULBMSM-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=CC=1C1CC1 AZISKSMZULBMSM-UHFFFAOYSA-N 0.000 description 1
• BOEZQUDSZKRROF-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=C(C)C=2)C2CC2)=C1 BOEZQUDSZKRROF-UHFFFAOYSA-N 0.000 description 1
• YBWNEANNPNQAEV-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=CC=1C1CC1 YBWNEANNPNQAEV-UHFFFAOYSA-N 0.000 description 1
• OZDIIEDZAMCNGN-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC=CC=2)C2CC2)=C1 OZDIIEDZAMCNGN-UHFFFAOYSA-N 0.000 description 1
• IMIABHYWOYUIFP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC=CC=2)C2CC2)=C1 IMIABHYWOYUIFP-UHFFFAOYSA-N 0.000 description 1
• BUTJRCJGXDCFCT-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC=CC=2)C2CC2)=C1 BUTJRCJGXDCFCT-UHFFFAOYSA-N 0.000 description 1
• OLRNCZKWPSXSKO-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CC2)=C1 OLRNCZKWPSXSKO-UHFFFAOYSA-N 0.000 description 1
• FSYKANAAXZIIDS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CC2)=C1 FSYKANAAXZIIDS-UHFFFAOYSA-N 0.000 description 1
• KEEIBMCHUQIKGE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CC2)=C1 KEEIBMCHUQIKGE-UHFFFAOYSA-N 0.000 description 1
• AHEPLOANRXEQKL-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-cyclopropylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C2CC2)=C1 AHEPLOANRXEQKL-UHFFFAOYSA-N 0.000 description 1
• PQKSSPVBXWJJSY-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethyl-6-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PQKSSPVBXWJJSY-UHFFFAOYSA-N 0.000 description 1
• SYEIZHUWSGRKFK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 SYEIZHUWSGRKFK-UHFFFAOYSA-N 0.000 description 1
• DMNNYLAWBHITAY-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical class CCC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 DMNNYLAWBHITAY-UHFFFAOYSA-N 0.000 description 1
• HGYGFXAKIKAXAE-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 HGYGFXAKIKAXAE-UHFFFAOYSA-N 0.000 description 1
• IVFHMVFVALEIHP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 IVFHMVFVALEIHP-UHFFFAOYSA-N 0.000 description 1
• SFFCGMUSTDBPCP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 SFFCGMUSTDBPCP-UHFFFAOYSA-N 0.000 description 1
• GAWGVGIFJHIAJX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(OC(F)(F)F)C=2)NC(=O)OC(C)(C)C)=C1 GAWGVGIFJHIAJX-UHFFFAOYSA-N 0.000 description 1
• LHRQEQNDWOPMMP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 LHRQEQNDWOPMMP-UHFFFAOYSA-N 0.000 description 1
• QSGQLXPYAUJXBX-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-pyrrol-1-ylphenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)N2C=CC=C2)NC(=O)OC(C)(C)C)=C1 QSGQLXPYAUJXBX-UHFFFAOYSA-N 0.000 description 1
• RQXCITFSHPMRBM-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(oxan-2-yloxymethyl)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(COC3OCCCC3)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 RQXCITFSHPMRBM-UHFFFAOYSA-N 0.000 description 1
• MJFGHEKMNSCRHL-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 MJFGHEKMNSCRHL-UHFFFAOYSA-N 0.000 description 1
• PWIVUWJXCISGCI-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(2-morpholin-4-ylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)N2CCOCC2)=C1 PWIVUWJXCISGCI-UHFFFAOYSA-N 0.000 description 1
• CRTUHSYQMXJIFJ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CRTUHSYQMXJIFJ-UHFFFAOYSA-N 0.000 description 1
• LDLFXXLNPUGDOB-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 LDLFXXLNPUGDOB-UHFFFAOYSA-N 0.000 description 1
• JIKGTETTXZRCNJ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CC(C)=NC=2)C)=C1 JIKGTETTXZRCNJ-UHFFFAOYSA-N 0.000 description 1
• IATKLHBGWSDXMA-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4,6-dimethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C)=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 IATKLHBGWSDXMA-UHFFFAOYSA-N 0.000 description 1
• NLRWJCQEWRBCLW-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC=NC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 NLRWJCQEWRBCLW-UHFFFAOYSA-N 0.000 description 1
• ZRBCNWHQJILXSH-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC=NC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 ZRBCNWHQJILXSH-UHFFFAOYSA-N 0.000 description 1
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• VYJSUUDJBHZGSC-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(5-ethyl-2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCC1=CN=C(C)C=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 VYJSUUDJBHZGSC-UHFFFAOYSA-N 0.000 description 1
• YCGPWHQHVGUNPW-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyanopyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C#N)=C1 YCGPWHQHVGUNPW-UHFFFAOYSA-N 0.000 description 1
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• WIICREGHTXRKNA-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-ethoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CC(=NC=2)C2CC2)C)=C1 WIICREGHTXRKNA-UHFFFAOYSA-N 0.000 description 1
• GKNSNJFCORUWLK-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=CC(C2CC2)=NC=C1C(C=1)=CC=CC=1C(=O)CC(=O)NC1=CC(C(F)(F)F)=C(C)C=C1NC(=O)OC(C)(C)C GKNSNJFCORUWLK-UHFFFAOYSA-N 0.000 description 1
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• AFOLXTOSCNMGRD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 AFOLXTOSCNMGRD-UHFFFAOYSA-N 0.000 description 1
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• FZBDRJQHDYVBSO-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 FZBDRJQHDYVBSO-UHFFFAOYSA-N 0.000 description 1
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• WVHLIYCNSRXLJD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 WVHLIYCNSRXLJD-UHFFFAOYSA-N 0.000 description 1
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• XXJWPPQNUFTAOZ-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(OC(F)(F)F)C=2)NC(=O)OC(C)(C)C)=C1 XXJWPPQNUFTAOZ-UHFFFAOYSA-N 0.000 description 1
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• QZSDRYHGXIVLGD-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=CC=2)NC(=O)OC(C)(C)C)=C1 QZSDRYHGXIVLGD-UHFFFAOYSA-N 0.000 description 1
• CHKRNPNGLRWUMS-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methoxypyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CHKRNPNGLRWUMS-UHFFFAOYSA-N 0.000 description 1
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• MOUMIOAJPKVWCP-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 MOUMIOAJPKVWCP-UHFFFAOYSA-N 0.000 description 1
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• ZCELBRNWROWOAG-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 ZCELBRNWROWOAG-UHFFFAOYSA-N 0.000 description 1
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• CGSOTBJBKAJWHG-UHFFFAOYSA-N tert-butyl n-[2-[[3-[3-[6-(dimethylamino)pyridin-3-yl]phenyl]-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(N(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CGSOTBJBKAJWHG-UHFFFAOYSA-N 0.000 description 1
• NZUUVGFYKKKXPB-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(2-pyridin-3-ylpyridin-4-yl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=NC(C=2C=NC=CC=2)=C1 NZUUVGFYKKKXPB-UHFFFAOYSA-N 0.000 description 1
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• JZILLAYPTWDNCT-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyrazin-2-ylphenyl)propanoyl]amino]-4-pyrrol-1-ylphenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(N2C=CC=C2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CN=CC=N1 JZILLAYPTWDNCT-UHFFFAOYSA-N 0.000 description 1
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• YCONOJOKKYQKBM-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]-4-(2-phenylethynyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CC=N1 YCONOJOKKYQKBM-UHFFFAOYSA-N 0.000 description 1
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• UNYJIADSXJRCEP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=CC=2)=C1 UNYJIADSXJRCEP-UHFFFAOYSA-N 0.000 description 1
• RMCNVDAGOLLBKG-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(OCC(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 RMCNVDAGOLLBKG-UHFFFAOYSA-N 0.000 description 1
• HXZMVCIKJVJCQO-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(2-phenylethynyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CN=C1 HXZMVCIKJVJCQO-UHFFFAOYSA-N 0.000 description 1
• DWDNHYOQWHZEAX-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(OC(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 DWDNHYOQWHZEAX-UHFFFAOYSA-N 0.000 description 1
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• ZPYDTMSSNAYDNW-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 ZPYDTMSSNAYDNW-UHFFFAOYSA-N 0.000 description 1
• MYUUDPKSWJXRIT-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-propoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 MYUUDPKSWJXRIT-UHFFFAOYSA-N 0.000 description 1
• PQJBIQCBKXIKHU-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-propyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 PQJBIQCBKXIKHU-UHFFFAOYSA-N 0.000 description 1
• KIWJJFBOGUDHQA-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C(NC(=O)OC(C)(C)C)=CC=1N1CCCC1 KIWJJFBOGUDHQA-UHFFFAOYSA-N 0.000 description 1
• KMAGHOMRZMSQFA-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 KMAGHOMRZMSQFA-UHFFFAOYSA-N 0.000 description 1
• NKAPFYHGQINYMV-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 NKAPFYHGQINYMV-UHFFFAOYSA-N 0.000 description 1
• STLZQVBAKLSDDP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 STLZQVBAKLSDDP-UHFFFAOYSA-N 0.000 description 1
• PPOBYHJKOFAPJC-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PPOBYHJKOFAPJC-UHFFFAOYSA-N 0.000 description 1
• YRLJBIAMGOUJNT-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-pyrrolidin-1-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical class CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)N2CCCC2)=C1 YRLJBIAMGOUJNT-UHFFFAOYSA-N 0.000 description 1
• SVZUQVDZBXGNEN-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(2-pyrrolidin-1-ylpyridin-4-yl)phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)N2CCCC2)=C1 SVZUQVDZBXGNEN-UHFFFAOYSA-N 0.000 description 1
• BFRQXKNNTHJHKQ-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(6-propan-2-ylpyridin-3-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 BFRQXKNNTHJHKQ-UHFFFAOYSA-N 0.000 description 1
• CAPZREDDLIZZHY-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-(6-propan-2-ylpyridin-3-yl)phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(OCC(F)(F)F)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 CAPZREDDLIZZHY-UHFFFAOYSA-N 0.000 description 1
• RCALJRMYKLASDP-UHFFFAOYSA-N tert-butyl n-[2-[[3-oxo-3-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]propanoyl]amino]-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(F)(F)F)=C1 RCALJRMYKLASDP-UHFFFAOYSA-N 0.000 description 1
• VZQQUUOWRMHQPG-UHFFFAOYSA-N tert-butyl n-[2-amino-4-chloro-5-[methyl(propan-2-yl)amino]phenyl]carbamate Chemical compound CC(C)N(C)C1=CC(NC(=O)OC(C)(C)C)=C(N)C=C1Cl VZQQUUOWRMHQPG-UHFFFAOYSA-N 0.000 description 1
• RSVLHUAHSFCCPQ-UHFFFAOYSA-N tert-butyl n-[2-nitro-4-(trifluoromethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(OC(F)(F)F)C=C1[N+]([O-])=O RSVLHUAHSFCCPQ-UHFFFAOYSA-N 0.000 description 1
• PHKCNXWTVZGKLM-UHFFFAOYSA-N tert-butyl n-[2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O PHKCNXWTVZGKLM-UHFFFAOYSA-N 0.000 description 1
• OWDYVWOBISSUIH-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(C(F)(F)F)C=C1[N+]([O-])=O OWDYVWOBISSUIH-UHFFFAOYSA-N 0.000 description 1
• GCNITTRPZHHGGU-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=CC=C1[N+]([O-])=O GCNITTRPZHHGGU-UHFFFAOYSA-N 0.000 description 1
• IKWPHCMXIKWDMJ-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-(oxan-2-yloxymethyl)-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C([N+]([O-])=O)C(NC(=O)OC(C)(C)C)=CC(COC2OCCCC2)=C1C(F)(F)F IKWPHCMXIKWDMJ-UHFFFAOYSA-N 0.000 description 1
• QTNLFONSWIGVPC-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-propoxy-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCCOC1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1C(F)(F)F QTNLFONSWIGVPC-UHFFFAOYSA-N 0.000 description 1
• GEGYSTYXJJPRBT-UHFFFAOYSA-N tert-butyl n-[2-nitro-5-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C([N+]([O-])=O)C(NC(=O)OC(C)(C)C)=CC(N2CCCC2)=C1C(F)(F)F GEGYSTYXJJPRBT-UHFFFAOYSA-N 0.000 description 1
• VVZPMMLFELNELO-UHFFFAOYSA-N tert-butyl n-[4-[2-(4-fluorophenyl)ethynyl]-2-[[3-oxo-3-(3-pyridin-2-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC(F)=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CC=N1 VVZPMMLFELNELO-UHFFFAOYSA-N 0.000 description 1
• FCEZDMQMHSZRDH-UHFFFAOYSA-N tert-butyl n-[4-[2-(4-fluorophenyl)ethynyl]-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(C#CC=2C=CC(F)=CC=2)C=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=CN=C1 FCEZDMQMHSZRDH-UHFFFAOYSA-N 0.000 description 1
• VMCZDVOUDACLSE-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(Cl)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 VMCZDVOUDACLSE-UHFFFAOYSA-N 0.000 description 1
• QDPXRPKRTHLBGR-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-[methyl(2-methylpropyl)amino]phenyl]carbamate Chemical compound C1=C(Cl)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 QDPXRPKRTHLBGR-UHFFFAOYSA-N 0.000 description 1
• UNLONZXJUYAWEQ-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 UNLONZXJUYAWEQ-UHFFFAOYSA-N 0.000 description 1
• IMWWDTSOVIAWKG-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2-cyanopyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C#N)=C1 IMWWDTSOVIAWKG-UHFFFAOYSA-N 0.000 description 1
• NQMNOPBAIYEGMC-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical class C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(Cl)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 NQMNOPBAIYEGMC-UHFFFAOYSA-N 0.000 description 1
• ZWDAKLYLAGRHKC-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methylphenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(=CC=2)C2CC2)=C1 ZWDAKLYLAGRHKC-UHFFFAOYSA-N 0.000 description 1
• LSWJZVKAMCSWKO-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-5-methylphenyl]carbamate Chemical compound C1=NC(CC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 LSWJZVKAMCSWKO-UHFFFAOYSA-N 0.000 description 1
• XCFCKOVHNVYAJH-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 XCFCKOVHNVYAJH-UHFFFAOYSA-N 0.000 description 1
• PKXCYFWUTLHLOW-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-5-(2,2,2-trifluoroethoxy)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC(F)(F)F)=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 PKXCYFWUTLHLOW-UHFFFAOYSA-N 0.000 description 1
• DQLSMBHPICEIKM-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 DQLSMBHPICEIKM-UHFFFAOYSA-N 0.000 description 1
• WQOSXOVPDUSLRR-UHFFFAOYSA-N tert-butyl n-[4-chloro-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(Cl)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 WQOSXOVPDUSLRR-UHFFFAOYSA-N 0.000 description 1
• NKQMESHTYIOCPN-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-(2-methylpropylamino)-2-nitrophenyl]carbamate Chemical compound CC(C)CNC1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1Cl NKQMESHTYIOCPN-UHFFFAOYSA-N 0.000 description 1
• HIJGGUTUMXRNPR-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-[methyl(2-methylpropyl)amino]-2-nitrophenyl]carbamate Chemical compound CC(C)CN(C)C1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1Cl HIJGGUTUMXRNPR-UHFFFAOYSA-N 0.000 description 1
• DHXRIXHZHMFOLC-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-ethoxy-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 DHXRIXHZHMFOLC-UHFFFAOYSA-N 0.000 description 1
• XMIUEPJSUSFUQD-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-fluoro-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(F)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 XMIUEPJSUSFUQD-UHFFFAOYSA-N 0.000 description 1
• WVMRVVSOSSLCAN-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 WVMRVVSOSSLCAN-UHFFFAOYSA-N 0.000 description 1
• ZMFJJJYNYCIREL-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=N1 ZMFJJJYNYCIREL-UHFFFAOYSA-N 0.000 description 1
• MYZABYHOAJHNGF-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 MYZABYHOAJHNGF-UHFFFAOYSA-N 0.000 description 1
• ICIISWNNUBLESU-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-[3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=CC=1COC1CCCCO1 ICIISWNNUBLESU-UHFFFAOYSA-N 0.000 description 1
• CGVDLYACFJEACR-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 CGVDLYACFJEACR-UHFFFAOYSA-N 0.000 description 1
• PIERZSOCQXGZKD-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-oxo-3-[3-(6-propan-2-ylpyridin-3-yl)phenyl]propanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(Cl)C=2)NC(=O)OC(C)(C)C)=C1 PIERZSOCQXGZKD-UHFFFAOYSA-N 0.000 description 1
• ZCPLTGWQXIPJPL-UHFFFAOYSA-N tert-butyl n-[4-chloro-5-methyl-2-[[3-oxo-3-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]propanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(F)(F)F)=C1 ZCPLTGWQXIPJPL-UHFFFAOYSA-N 0.000 description 1
• DYRAPSKBJKDTGN-UHFFFAOYSA-N tert-butyl n-[4-fluoro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 DYRAPSKBJKDTGN-UHFFFAOYSA-N 0.000 description 1
• NFBDWKSVJXYHCF-UHFFFAOYSA-N tert-butyl n-[4-fluoro-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=C(F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 NFBDWKSVJXYHCF-UHFFFAOYSA-N 0.000 description 1
• QBTMCRKXPQESSF-UHFFFAOYSA-N tert-butyl n-[4-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]-5-(trifluoromethyl)phenyl]carbamate Chemical class CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C)C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=N1 QBTMCRKXPQESSF-UHFFFAOYSA-N 0.000 description 1
• VWIIAKIRBQBGBZ-UHFFFAOYSA-N tert-butyl n-[5-(2-methoxyethoxy)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCOC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 VWIIAKIRBQBGBZ-UHFFFAOYSA-N 0.000 description 1
• VZPXPKDKSQRPIF-UHFFFAOYSA-N tert-butyl n-[5-(2-methoxyethoxy)-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCCOC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 VZPXPKDKSQRPIF-UHFFFAOYSA-N 0.000 description 1
• BJEUMHJPDGOPEB-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(OCC3CC3)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 BJEUMHJPDGOPEB-UHFFFAOYSA-N 0.000 description 1
• UGYMLBBXUDNUEI-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-[3-(6-cyclopropylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC(=CC=2)C2CC2)C(NC(=O)OC(C)(C)C)=CC=1OCC1CC1 UGYMLBBXUDNUEI-UHFFFAOYSA-N 0.000 description 1
• TZEACKVNBPGUOX-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound FC(F)(F)C=1C=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C(NC(=O)OC(C)(C)C)=CC=1OCC1CC1 TZEACKVNBPGUOX-UHFFFAOYSA-N 0.000 description 1
• DBSPUNGWCRETDA-UHFFFAOYSA-N tert-butyl n-[5-(cyclopropylmethoxy)-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C([N+]([O-])=O)C(NC(=O)OC(C)(C)C)=CC(OCC2CC2)=C1C(F)(F)F DBSPUNGWCRETDA-UHFFFAOYSA-N 0.000 description 1
• QQKHNGOWTLVSJO-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=C(C)C=2)=C1 QQKHNGOWTLVSJO-UHFFFAOYSA-N 0.000 description 1
• HQIQHMVJFHZSNI-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(2-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC=CC=2)C)=C1 HQIQHMVJFHZSNI-UHFFFAOYSA-N 0.000 description 1
• YLYQVAJQRLJSAF-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 YLYQVAJQRLJSAF-UHFFFAOYSA-N 0.000 description 1
• QEZOLOLBNJYXCI-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methoxypyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound N1=NC(OC)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)N(C)C)NC(=O)OC(C)(C)C)=C1 QEZOLOLBNJYXCI-UHFFFAOYSA-N 0.000 description 1
• SAQONGYYTBDYNR-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methylpyridazin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=NC(C)=CC=2)=C1 SAQONGYYTBDYNR-UHFFFAOYSA-N 0.000 description 1
• KPZQETHUCBOIEN-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methylpyridin-2-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=C(C)C=CC=2)=C1 KPZQETHUCBOIEN-UHFFFAOYSA-N 0.000 description 1
• FGXZSNWJBLESHN-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(C)=CC=2)=C1 FGXZSNWJBLESHN-UHFFFAOYSA-N 0.000 description 1
• CYHKYIHNWZMSTE-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 CYHKYIHNWZMSTE-UHFFFAOYSA-N 0.000 description 1
• QSOKYLAWCXMFLQ-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CN(C)C1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1C(F)(F)F QSOKYLAWCXMFLQ-UHFFFAOYSA-N 0.000 description 1
• LXESDSJTWCYMCF-UHFFFAOYSA-N tert-butyl n-[5-(dimethylamino)-4-(2-fluorophenyl)-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound C1=C(C=2C(=CC=CC=2)F)C(N(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C(C=1)=CC=CC=1C1=CC=NC=C1 LXESDSJTWCYMCF-UHFFFAOYSA-N 0.000 description 1
• ZXELKRCHWGUXOM-UHFFFAOYSA-N tert-butyl n-[5-[cyclopropyl(methyl)amino]-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C=1C(NC(=O)OC(C)(C)C)=C(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2C=NC=CC=2)C=C(C(F)(F)F)C=1N(C)C1CC1 ZXELKRCHWGUXOM-UHFFFAOYSA-N 0.000 description 1
• DFACHXTWSXOIER-UHFFFAOYSA-N tert-butyl n-[5-[methyl(2-methylpropyl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 DFACHXTWSXOIER-UHFFFAOYSA-N 0.000 description 1
• YUFKUZUHQXWZRI-UHFFFAOYSA-N tert-butyl n-[5-[methyl(2-methylpropyl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CC(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 YUFKUZUHQXWZRI-UHFFFAOYSA-N 0.000 description 1
• CZPDQHYOZKYZKK-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propan-2-yl)amino]-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 CZPDQHYOZKYZKK-UHFFFAOYSA-N 0.000 description 1
• YPTOGHWMHINNLF-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propan-2-yl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)C(C)C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 YPTOGHWMHINNLF-UHFFFAOYSA-N 0.000 description 1
• BPMURVIOBACFFO-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 BPMURVIOBACFFO-UHFFFAOYSA-N 0.000 description 1
• OMXQDZGLFAFFMG-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-oxo-3-(3-pyrazin-2-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2N=CC=NC=2)=C1 OMXQDZGLFAFFMG-UHFFFAOYSA-N 0.000 description 1
• DHRPZVAAUNBRBI-UHFFFAOYSA-N tert-butyl n-[5-[methyl(propyl)amino]-2-[[3-oxo-3-(3-pyridin-4-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=C(C(F)(F)F)C(N(C)CCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=CN=CC=2)=C1 DHRPZVAAUNBRBI-UHFFFAOYSA-N 0.000 description 1
• JEJOABWZPOUSTK-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,3-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1C JEJOABWZPOUSTK-UHFFFAOYSA-N 0.000 description 1
• ZJQAGBSNOVCCRC-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,5-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1C ZJQAGBSNOVCCRC-UHFFFAOYSA-N 0.000 description 1
• PJIWZZUXQDIICJ-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2,6-dimethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 PJIWZZUXQDIICJ-UHFFFAOYSA-N 0.000 description 1
• JQALVDYZZKDKBC-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 JQALVDYZZKDKBC-UHFFFAOYSA-N 0.000 description 1
• FAFVIQRAMQAMOH-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(CC(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 FAFVIQRAMQAMOH-UHFFFAOYSA-N 0.000 description 1
• LUFILFIFMYNLHC-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 LUFILFIFMYNLHC-UHFFFAOYSA-N 0.000 description 1
• UMTLAMPZCNPWLG-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-[3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound N=1C(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=CC=1COC1CCCCO1 UMTLAMPZCNPWLG-UHFFFAOYSA-N 0.000 description 1
• VGBZSTZEVUARLR-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 VGBZSTZEVUARLR-UHFFFAOYSA-N 0.000 description 1
• TWVMUYWBEQVMAP-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C(C)C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 TWVMUYWBEQVMAP-UHFFFAOYSA-N 0.000 description 1
• DBRLMEJJMQUJIN-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-[[3-oxo-3-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(Cl)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(F)(F)F)=C1 DBRLMEJJMQUJIN-UHFFFAOYSA-N 0.000 description 1
• HPOFWGSBPYENNC-UHFFFAOYSA-N tert-butyl n-[5-chloro-4-methyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C)C=2)NC(=O)OC(C)(C)C)=C1 HPOFWGSBPYENNC-UHFFFAOYSA-N 0.000 description 1
• KSOYVPMGIZSKDD-UHFFFAOYSA-N tert-butyl n-[5-chloro-4-methyl-2-[[3-[3-(6-methylpyrazin-2-yl)phenyl]-3-oxopropanoyl]amino]phenyl]carbamate Chemical compound CC1=CN=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(Cl)=C(C)C=2)NC(=O)OC(C)(C)C)=N1 KSOYVPMGIZSKDD-UHFFFAOYSA-N 0.000 description 1
• WGLJQSMQTFHIEH-UHFFFAOYSA-N tert-butyl n-[5-chloro-4-methyl-2-[[3-oxo-3-(3-pyrazin-2-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(C)=CC(NC(=O)CC(=O)C=2C=C(C=CC=2)C=2N=CC=NC=2)=C1NC(=O)OC(C)(C)C WGLJQSMQTFHIEH-UHFFFAOYSA-N 0.000 description 1
• KKIWZIPGDCNEAM-UHFFFAOYSA-N tert-butyl n-[5-cyclopropyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(=C(C=2)C(F)(F)F)C2CC2)NC(=O)OC(C)(C)C)=C1 KKIWZIPGDCNEAM-UHFFFAOYSA-N 0.000 description 1
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• WDELDXMEHREJDT-UHFFFAOYSA-N tert-butyl n-[5-ethenyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=NC(C)=CC(C=2C=C(C=CC=2)C(=O)CC(=O)NC=2C(=CC(C=C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 WDELDXMEHREJDT-UHFFFAOYSA-N 0.000 description 1
• DAMTZMIPHMORPZ-UHFFFAOYSA-N tert-butyl n-[5-ethenyl-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(C=C)=C(C(F)(F)F)C=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 DAMTZMIPHMORPZ-UHFFFAOYSA-N 0.000 description 1
• UQOUWWYMUATNBB-UHFFFAOYSA-N tert-butyl n-[5-ethenyl-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(C=C)=C(C(F)(F)F)C=C1[N+]([O-])=O UQOUWWYMUATNBB-UHFFFAOYSA-N 0.000 description 1
• YRIKBUOKVUJJCE-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(2-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=NC=CC=2)CC)=C1 YRIKBUOKVUJJCE-UHFFFAOYSA-N 0.000 description 1
• UQKWVFOAKZZKST-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(2-ethylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(CC)N=CC=2)=C1 UQKWVFOAKZZKST-UHFFFAOYSA-N 0.000 description 1
• FUQBLUYCWKHFPN-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 FUQBLUYCWKHFPN-UHFFFAOYSA-N 0.000 description 1
• YGZGBAOFCZGNDH-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(4-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C(=CC=NC=2)C)=C1 YGZGBAOFCZGNDH-UHFFFAOYSA-N 0.000 description 1
• ZRIAALBLUUSZKG-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(6-ethylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(CC)=CC=2)=C1 ZRIAALBLUUSZKG-UHFFFAOYSA-N 0.000 description 1
• KBSZDRGLOQDZDI-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC(C)=CC=2)=C1 KBSZDRGLOQDZDI-UHFFFAOYSA-N 0.000 description 1
• MAMRSPDHTRGHLW-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-[2-(2-methylpropyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(CC(C)C)N=CC=2)=C1 MAMRSPDHTRGHLW-UHFFFAOYSA-N 0.000 description 1
• XIAUSMVWURUJCY-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-[2-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=CC=2)=C1 XIAUSMVWURUJCY-UHFFFAOYSA-N 0.000 description 1
• XQNUXIRZQBYDSG-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-[3-[2-methyl-6-(oxan-2-yloxymethyl)pyridin-4-yl]phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(COC3OCCCC3)N=C(C)C=2)=C1 XQNUXIRZQBYDSG-UHFFFAOYSA-N 0.000 description 1
• BANBPEXLLUZZOF-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-oxo-3-(2-pyridin-3-ylpyridin-4-yl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=NC(C=2C=NC=CC=2)=C1 BANBPEXLLUZZOF-UHFFFAOYSA-N 0.000 description 1
• WMDLOCVWROFAII-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 WMDLOCVWROFAII-UHFFFAOYSA-N 0.000 description 1
• NDEBSJDZESYGTF-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-oxo-3-(3-pyridin-3-ylphenyl)propanoyl]amino]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(OCC)=CC=C1NC(=O)CC(=O)C1=CC=CC(C=2C=NC=CC=2)=C1 NDEBSJDZESYGTF-UHFFFAOYSA-N 0.000 description 1
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• HBIHVQVMEWYOPM-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-[[3-oxo-3-[3-(2-propan-2-ylpyridin-4-yl)phenyl]propanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(N=CC=2)C(C)C)=C1 HBIHVQVMEWYOPM-UHFFFAOYSA-N 0.000 description 1
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• IWYNYIRMZJXRJQ-UHFFFAOYSA-N tert-butyl n-[5-ethoxy-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CCOC1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1C(F)(F)F IWYNYIRMZJXRJQ-UHFFFAOYSA-N 0.000 description 1
• ZDZCLLXQJOPDJH-UHFFFAOYSA-N tert-butyl n-[5-ethyl-2-[[3-[3-(2-methylpyridin-4-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical class C1=C(C(F)(F)F)C(CC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C=2C=C(C)N=CC=2)=C1 ZDZCLLXQJOPDJH-UHFFFAOYSA-N 0.000 description 1
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• DTOKUIFRHZLFTL-UHFFFAOYSA-N tert-butyl n-[5-methyl-2-[[3-[3-(6-methylpyridin-3-yl)phenyl]-3-oxopropanoyl]amino]-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=NC(C)=CC=C1C1=CC=CC(C(=O)CC(=O)NC=2C(=CC(C)=C(C=2)C(F)(F)F)NC(=O)OC(C)(C)C)=C1 DTOKUIFRHZLFTL-UHFFFAOYSA-N 0.000 description 1
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