CN100439336C - 制备环状苯甲脒衍生物的方法 - Google Patents

制备环状苯甲脒衍生物的方法 Download PDF

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Publication number
CN100439336C
CN100439336C CNB2004800105008A CN200480010500A CN100439336C CN 100439336 C CN100439336 C CN 100439336C CN B2004800105008 A CNB2004800105008 A CN B2004800105008A CN 200480010500 A CN200480010500 A CN 200480010500A CN 100439336 C CN100439336 C CN 100439336C
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China
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compound
expression
salt
formula
reaction
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN1777583A (zh
Inventor
下村直之
佐生学
栢野明生
吉泽一洋
辻井昌彦
黑田浩史
布留川健
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R&amp D Management Co Ltd
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Sanitary Material R&d Management Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
CNB2004800105008A 2003-02-19 2004-02-10 制备环状苯甲脒衍生物的方法 Expired - Fee Related CN100439336C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003040949 2003-02-19
JP040949/2003 2003-02-19

Publications (2)

Publication Number Publication Date
CN1777583A CN1777583A (zh) 2006-05-24
CN100439336C true CN100439336C (zh) 2008-12-03

Family

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Family Applications (1)

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CNB2004800105008A Expired - Fee Related CN100439336C (zh) 2003-02-19 2004-02-10 制备环状苯甲脒衍生物的方法

Country Status (10)

Country Link
US (1) US7375236B2 (enExample)
EP (2) EP1602646A4 (enExample)
JP (1) JP4549970B2 (enExample)
KR (1) KR20050104376A (enExample)
CN (1) CN100439336C (enExample)
AU (1) AU2004218187C1 (enExample)
CA (1) CA2515715C (enExample)
IL (1) IL170175A (enExample)
TW (1) TW200500340A (enExample)
WO (1) WO2004078721A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106905388A (zh) * 2017-02-16 2017-06-30 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

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US7585982B2 (en) 2004-08-16 2009-09-08 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
JP4787757B2 (ja) 2004-08-17 2011-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 ジブロモフルオロベンゼン誘導体の製造方法
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CN101917990B (zh) 2008-01-11 2012-11-28 卫材R&D管理有限公司 药物组合物、2-亚氨基吡咯烷衍生物用于制造药物组合物的用途和心脏病治疗用或改善用试剂盒
DK2240487T3 (da) 2008-02-05 2012-04-02 Sanofi Sa Triazolopyridaziner som para-inhibitorer, fremstilling og anvendelse heraf som lægemiddel
RU2494100C2 (ru) 2008-02-05 2013-09-27 Санофи-Авентис Соли триазолия в качестве ингибиторов par1, их получение и применение в качестве лекарственного средства
EP2242740B1 (de) 2008-02-05 2012-12-12 Sanofi Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
US20120053067A1 (en) 2009-05-04 2012-03-01 University Of Maryland, Baltimore Method for binding site identification by molecular dynamics simulation (silcs: site identification by ligand competitive saturation)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
US20150095007A1 (en) * 2012-03-20 2015-04-02 University Of Maryland, Baltimore Site-specific fragment identification guided by single-step free energy perturbation calculations

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106905388A (zh) * 2017-02-16 2017-06-30 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

Also Published As

Publication number Publication date
TW200500340A (en) 2005-01-01
TWI305774B (enExample) 2009-02-01
EP2444393A1 (en) 2012-04-25
US7375236B2 (en) 2008-05-20
US20060058370A1 (en) 2006-03-16
JPWO2004078721A1 (ja) 2006-06-08
EP1602646A4 (en) 2010-07-28
AU2004218187A1 (en) 2004-09-16
KR20050104376A (ko) 2005-11-02
HK1091494A1 (zh) 2007-01-19
CA2515715C (en) 2012-05-08
WO2004078721A1 (ja) 2004-09-16
AU2004218187B2 (en) 2010-09-30
EP1602646A1 (en) 2005-12-07
IL170175A (en) 2010-12-30
CA2515715A1 (en) 2004-09-16
AU2004218187C1 (en) 2011-04-07
CN1777583A (zh) 2006-05-24
JP4549970B2 (ja) 2010-09-22

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