KR20050104376A - 고리형상 벤즈아미딘 유도체의 제조방법 - Google Patents

고리형상 벤즈아미딘 유도체의 제조방법 Download PDF

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Publication number
KR20050104376A
KR20050104376A KR1020057015182A KR20057015182A KR20050104376A KR 20050104376 A KR20050104376 A KR 20050104376A KR 1020057015182 A KR1020057015182 A KR 1020057015182A KR 20057015182 A KR20057015182 A KR 20057015182A KR 20050104376 A KR20050104376 A KR 20050104376A
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KR
South Korea
Prior art keywords
formula
group
compound
compound represented
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020057015182A
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English (en)
Korean (ko)
Inventor
나오유키 시모무라
마나부 사소
아키오 카야노
카즈히로 요시자와
마사히코 츠지이
히로시 쿠로다
켄 후루카와
Original Assignee
에자이 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에자이 가부시키가이샤 filed Critical 에자이 가부시키가이샤
Publication of KR20050104376A publication Critical patent/KR20050104376A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
KR1020057015182A 2003-02-19 2004-02-10 고리형상 벤즈아미딘 유도체의 제조방법 Abandoned KR20050104376A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003040949 2003-02-19
JPJP-P-2003-00040949 2003-02-19

Publications (1)

Publication Number Publication Date
KR20050104376A true KR20050104376A (ko) 2005-11-02

Family

ID=32958626

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057015182A Abandoned KR20050104376A (ko) 2003-02-19 2004-02-10 고리형상 벤즈아미딘 유도체의 제조방법

Country Status (10)

Country Link
US (1) US7375236B2 (enExample)
EP (2) EP1602646A4 (enExample)
JP (1) JP4549970B2 (enExample)
KR (1) KR20050104376A (enExample)
CN (1) CN100439336C (enExample)
AU (1) AU2004218187C1 (enExample)
CA (1) CA2515715C (enExample)
IL (1) IL170175A (enExample)
TW (1) TW200500340A (enExample)
WO (1) WO2004078721A1 (enExample)

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ATE534627T1 (de) 2001-04-19 2011-12-15 Eisai R&D Man Co Ltd 2-iminopyrrolidin-derivate
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US7585982B2 (en) 2004-08-16 2009-09-08 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
JP4787757B2 (ja) 2004-08-17 2011-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 ジブロモフルオロベンゼン誘導体の製造方法
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DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
CN101917990B (zh) 2008-01-11 2012-11-28 卫材R&D管理有限公司 药物组合物、2-亚氨基吡咯烷衍生物用于制造药物组合物的用途和心脏病治疗用或改善用试剂盒
DK2240487T3 (da) 2008-02-05 2012-04-02 Sanofi Sa Triazolopyridaziner som para-inhibitorer, fremstilling og anvendelse heraf som lægemiddel
RU2494100C2 (ru) 2008-02-05 2013-09-27 Санофи-Авентис Соли триазолия в качестве ингибиторов par1, их получение и применение в качестве лекарственного средства
EP2242740B1 (de) 2008-02-05 2012-12-12 Sanofi Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
US20120053067A1 (en) 2009-05-04 2012-03-01 University Of Maryland, Baltimore Method for binding site identification by molecular dynamics simulation (silcs: site identification by ligand competitive saturation)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
US20150095007A1 (en) * 2012-03-20 2015-04-02 University Of Maryland, Baltimore Site-specific fragment identification guided by single-step free energy perturbation calculations
CN106905388B (zh) * 2017-02-16 2021-01-01 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

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Also Published As

Publication number Publication date
TW200500340A (en) 2005-01-01
TWI305774B (enExample) 2009-02-01
EP2444393A1 (en) 2012-04-25
US7375236B2 (en) 2008-05-20
US20060058370A1 (en) 2006-03-16
JPWO2004078721A1 (ja) 2006-06-08
EP1602646A4 (en) 2010-07-28
CN100439336C (zh) 2008-12-03
AU2004218187A1 (en) 2004-09-16
HK1091494A1 (zh) 2007-01-19
CA2515715C (en) 2012-05-08
WO2004078721A1 (ja) 2004-09-16
AU2004218187B2 (en) 2010-09-30
EP1602646A1 (en) 2005-12-07
IL170175A (en) 2010-12-30
CA2515715A1 (en) 2004-09-16
AU2004218187C1 (en) 2011-04-07
CN1777583A (zh) 2006-05-24
JP4549970B2 (ja) 2010-09-22

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