TW200500340A - Processes for producing cyclic benzamidine derivative - Google Patents
Processes for producing cyclic benzamidine derivativeInfo
- Publication number
- TW200500340A TW200500340A TW093103470A TW93103470A TW200500340A TW 200500340 A TW200500340 A TW 200500340A TW 093103470 A TW093103470 A TW 093103470A TW 93103470 A TW93103470 A TW 93103470A TW 200500340 A TW200500340 A TW 200500340A
- Authority
- TW
- Taiwan
- Prior art keywords
- salt
- compound
- benzamidine derivative
- cyclic benzamidine
- producing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- -1 cyclic benzamidine derivative Chemical class 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 239000012046 mixed solvent Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical class [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003040949 | 2003-02-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200500340A true TW200500340A (en) | 2005-01-01 |
| TWI305774B TWI305774B (enExample) | 2009-02-01 |
Family
ID=32958626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093103470A TW200500340A (en) | 2003-02-19 | 2004-02-13 | Processes for producing cyclic benzamidine derivative |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7375236B2 (enExample) |
| EP (2) | EP2444393A1 (enExample) |
| JP (1) | JP4549970B2 (enExample) |
| KR (1) | KR20050104376A (enExample) |
| CN (1) | CN100439336C (enExample) |
| AU (1) | AU2004218187C1 (enExample) |
| CA (1) | CA2515715C (enExample) |
| IL (1) | IL170175A (enExample) |
| TW (1) | TW200500340A (enExample) |
| WO (1) | WO2004078721A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7476688B2 (en) | 2001-04-19 | 2009-01-13 | Eisai R&D Management Co., Ltd. | Cyclic amidine derivatives |
| JP4549970B2 (ja) | 2003-02-19 | 2010-09-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 環状ベンズアミジン誘導体の製造方法 |
| KR20070062520A (ko) | 2004-08-16 | 2007-06-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 이소인돌 유도체의 제조방법 |
| JP4787757B2 (ja) | 2004-08-17 | 2011-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ジブロモフルオロベンゼン誘導体の製造方法 |
| US7786330B2 (en) | 2005-02-28 | 2010-08-31 | Asahi Glass Company, Limited | Process for producing 1,2-dialkoxy-3-fluorobenzene |
| DE102006036023A1 (de) | 2006-08-02 | 2008-02-07 | Sanofi-Aventis | Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität |
| JPWO2008023438A1 (ja) | 2006-08-25 | 2010-01-07 | 旭硝子株式会社 | １，２−ジアルコキシ−３−フルオロベンゼンの製造方法 |
| EP2241315B1 (en) | 2008-01-11 | 2013-12-11 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases |
| CN101981034B (zh) | 2008-02-05 | 2013-08-14 | 赛诺菲-安万特 | 作为par1抑制剂的三唑并哒嗪、其制备及其制备药物的用途 |
| BRPI0907487A2 (pt) | 2008-02-05 | 2015-07-14 | Sanofi Aventis | Sais de triazólio como inibidores de par1, produção dos mesmos e uso como medicamentos |
| SI2242740T1 (sl) | 2008-02-05 | 2013-03-29 | Sanofi | SF5-derivati kot PAR1 inhibitorji, njihova priprava in uporaba kot zdravila |
| US20100056519A1 (en) * | 2008-07-15 | 2010-03-04 | Serebruany Victor L | Composition and method for reducing platelet activation and for the treatment of thrombotic events |
| EP2427769A4 (en) | 2009-05-04 | 2016-08-03 | Univ Maryland | METHOD FOR IDENTIFYING BINDING LOCATIONS THROUGH MOLECULE DYNAMICS SIMULATION (LOCATION IDENTIFICATION BY COMPETITIVE LIGAND SENSITIVITY) |
| US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
| CN102757396B (zh) * | 2011-04-28 | 2014-10-15 | 天津药物研究院 | 含苯并五元杂环的环外亚胺化合物、其制备方法和用途 |
| WO2013142630A1 (en) * | 2012-03-20 | 2013-09-26 | University Of Maryland, Baltimore | Site-specific fragment identification guided by single-step free energy perturbation calculations |
| CN106905388B (zh) * | 2017-02-16 | 2021-01-01 | 重庆西南制药二厂有限责任公司 | 一种天麻素的合成方法 |
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| JP3725843B2 (ja) | 2002-07-05 | 2005-12-14 | ローム株式会社 | 反射型センサ |
| JP4549970B2 (ja) | 2003-02-19 | 2010-09-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 環状ベンズアミジン誘導体の製造方法 |
| KR20070062520A (ko) | 2004-08-16 | 2007-06-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 이소인돌 유도체의 제조방법 |
| JP4787757B2 (ja) | 2004-08-17 | 2011-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ジブロモフルオロベンゼン誘導体の製造方法 |
-
2004
- 2004-02-10 JP JP2005502995A patent/JP4549970B2/ja not_active Expired - Fee Related
- 2004-02-10 WO PCT/JP2004/001396 patent/WO2004078721A1/ja not_active Ceased
- 2004-02-10 CA CA2515715A patent/CA2515715C/en not_active Expired - Fee Related
- 2004-02-10 KR KR1020057015182A patent/KR20050104376A/ko not_active Abandoned
- 2004-02-10 EP EP12150545A patent/EP2444393A1/en not_active Withdrawn
- 2004-02-10 CN CNB2004800105008A patent/CN100439336C/zh not_active Expired - Fee Related
- 2004-02-10 EP EP04709710A patent/EP1602646A4/en not_active Withdrawn
- 2004-02-10 AU AU2004218187A patent/AU2004218187C1/en not_active Ceased
- 2004-02-13 TW TW093103470A patent/TW200500340A/zh not_active IP Right Cessation
-
2005
- 2005-08-09 IL IL170175A patent/IL170175A/en not_active IP Right Cessation
- 2005-08-18 US US11/208,289 patent/US7375236B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004218187A1 (en) | 2004-09-16 |
| TWI305774B (enExample) | 2009-02-01 |
| EP2444393A1 (en) | 2012-04-25 |
| CN100439336C (zh) | 2008-12-03 |
| IL170175A (en) | 2010-12-30 |
| JPWO2004078721A1 (ja) | 2006-06-08 |
| CA2515715C (en) | 2012-05-08 |
| JP4549970B2 (ja) | 2010-09-22 |
| EP1602646A4 (en) | 2010-07-28 |
| HK1091494A1 (zh) | 2007-01-19 |
| US7375236B2 (en) | 2008-05-20 |
| CN1777583A (zh) | 2006-05-24 |
| EP1602646A1 (en) | 2005-12-07 |
| AU2004218187B2 (en) | 2010-09-30 |
| AU2004218187C1 (en) | 2011-04-07 |
| KR20050104376A (ko) | 2005-11-02 |
| WO2004078721A1 (ja) | 2004-09-16 |
| US20060058370A1 (en) | 2006-03-16 |
| CA2515715A1 (en) | 2004-09-16 |
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