JP4549970B2 - 環状ベンズアミジン誘導体の製造方法 - Google Patents

環状ベンズアミジン誘導体の製造方法 Download PDF

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Publication number
JP4549970B2
JP4549970B2 JP2005502995A JP2005502995A JP4549970B2 JP 4549970 B2 JP4549970 B2 JP 4549970B2 JP 2005502995 A JP2005502995 A JP 2005502995A JP 2005502995 A JP2005502995 A JP 2005502995A JP 4549970 B2 JP4549970 B2 JP 4549970B2
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formula
compound
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represented
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Japanese (ja)
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JPWO2004078721A1 (ja
Inventor
直之 下村
学 佐生
明生 栢野
一洋 吉澤
昌彦 辻井
浩史 黒田
健 布留川
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
JP2005502995A 2003-02-19 2004-02-10 環状ベンズアミジン誘導体の製造方法 Expired - Fee Related JP4549970B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003040949 2003-02-19
JP2003040949 2003-02-19
PCT/JP2004/001396 WO2004078721A1 (ja) 2003-02-19 2004-02-10 環状ベンズアミジン誘導体の製造方法

Publications (2)

Publication Number Publication Date
JPWO2004078721A1 JPWO2004078721A1 (ja) 2006-06-08
JP4549970B2 true JP4549970B2 (ja) 2010-09-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005502995A Expired - Fee Related JP4549970B2 (ja) 2003-02-19 2004-02-10 環状ベンズアミジン誘導体の製造方法

Country Status (10)

Country Link
US (1) US7375236B2 (enExample)
EP (2) EP1602646A4 (enExample)
JP (1) JP4549970B2 (enExample)
KR (1) KR20050104376A (enExample)
CN (1) CN100439336C (enExample)
AU (1) AU2004218187C1 (enExample)
CA (1) CA2515715C (enExample)
IL (1) IL170175A (enExample)
TW (1) TW200500340A (enExample)
WO (1) WO2004078721A1 (enExample)

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RU2270192C2 (ru) 2001-04-19 2006-02-20 Эйсай Ко., Лтд. Производные 2-иминопирролидина
EP1602646A4 (en) 2003-02-19 2010-07-28 Eisai R&D Man Co Ltd PROCESS FOR PREPARING CYCLIC BENZAMIDINE DERIVATIVES
JP4820295B2 (ja) 2004-08-16 2011-11-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 イソインドール誘導体の製造方法
WO2006018954A1 (ja) 2004-08-17 2006-02-23 Eisai R & D Management Co., Ltd. ジブロモフルオロベンゼン誘導体の製造方法
US7786330B2 (en) 2005-02-28 2010-08-31 Asahi Glass Company, Limited Process for producing 1,2-dialkoxy-3-fluorobenzene
WO2008023438A1 (en) 2006-08-25 2008-02-28 Asahi Glass Co., Ltd. Process for producing 1,2-dialkoxy-3-fluorobenzene
DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
WO2009088063A1 (ja) 2008-01-11 2009-07-16 Eisai R & D Management Co., Ltd. 医薬組成物、医薬組成物製造のための２－イミノピロリジン誘導体の使用および心疾患の治療用または改善用キット
MY152040A (en) 2008-02-05 2014-08-15 Sanofi Aventis Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
CA2713551C (en) 2008-02-05 2016-06-14 Sanofi-Aventis Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
WO2009097972A1 (de) 2008-02-05 2009-08-13 Sanofi-Aventis Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
EP2427769A4 (en) 2009-05-04 2016-08-03 Univ Maryland METHOD FOR IDENTIFYING BINDING LOCATIONS THROUGH MOLECULE DYNAMICS SIMULATION (LOCATION IDENTIFICATION BY COMPETITIVE LIGAND SENSITIVITY)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
US20150095007A1 (en) * 2012-03-20 2015-04-02 University Of Maryland, Baltimore Site-specific fragment identification guided by single-step free energy perturbation calculations
CN106905388B (zh) * 2017-02-16 2021-01-01 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

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Also Published As

Publication number Publication date
AU2004218187C1 (en) 2011-04-07
CA2515715A1 (en) 2004-09-16
CA2515715C (en) 2012-05-08
TW200500340A (en) 2005-01-01
US7375236B2 (en) 2008-05-20
IL170175A (en) 2010-12-30
EP2444393A1 (en) 2012-04-25
KR20050104376A (ko) 2005-11-02
AU2004218187B2 (en) 2010-09-30
EP1602646A4 (en) 2010-07-28
WO2004078721A1 (ja) 2004-09-16
CN1777583A (zh) 2006-05-24
AU2004218187A1 (en) 2004-09-16
JPWO2004078721A1 (ja) 2006-06-08
HK1091494A1 (zh) 2007-01-19
CN100439336C (zh) 2008-12-03
EP1602646A1 (en) 2005-12-07
TWI305774B (enExample) 2009-02-01
US20060058370A1 (en) 2006-03-16

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