CN100418964C - (s,s)-顺式-2-二苯甲基-3-苄基氨基奎宁环的制备方法 - Google Patents

(s,s)-顺式-2-二苯甲基-3-苄基氨基奎宁环的制备方法 Download PDF

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Publication number
CN100418964C
CN100418964C CNB200380101563XA CN200380101563A CN100418964C CN 100418964 C CN100418964 C CN 100418964C CN B200380101563X A CNB200380101563X A CN B200380101563XA CN 200380101563 A CN200380101563 A CN 200380101563A CN 100418964 C CN100418964 C CN 100418964C
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China
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acid
organic
salt
isomer
chiral
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Expired - Fee Related
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CNB200380101563XA
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English (en)
Chinese (zh)
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CN1705664A (zh
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T·C·努根特
R·希梅尔
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Pfizer Products Inc
DSM Pharmaceuticals Inc
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Pfizer Products Inc
DSM Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB200380101563XA 2002-10-16 2003-10-10 (s,s)-顺式-2-二苯甲基-3-苄基氨基奎宁环的制备方法 Expired - Fee Related CN100418964C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41905102P 2002-10-16 2002-10-16
US60/419,051 2002-10-16
PCT/US2003/032275 WO2004035575A1 (en) 2002-10-16 2003-10-10 Process for the preparation of (s,s)-cis-2-benzhydryl-3-benzylaminoquinuclidine

Publications (2)

Publication Number Publication Date
CN1705664A CN1705664A (zh) 2005-12-07
CN100418964C true CN100418964C (zh) 2008-09-17

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CNB200380101563XA Expired - Fee Related CN100418964C (zh) 2002-10-16 2003-10-10 (s,s)-顺式-2-二苯甲基-3-苄基氨基奎宁环的制备方法

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US (2) US6861526B2 (enExample)
EP (1) EP1551833A4 (enExample)
JP (1) JP2006506368A (enExample)
KR (1) KR100739901B1 (enExample)
CN (1) CN100418964C (enExample)
AP (1) AP2005003288A0 (enExample)
AR (1) AR041587A1 (enExample)
AU (1) AU2003277353B2 (enExample)
BR (1) BR0315335A (enExample)
CA (1) CA2500635A1 (enExample)
EA (1) EA008192B1 (enExample)
HR (1) HRP20050328A2 (enExample)
IS (1) IS7755A (enExample)
MX (1) MXPA05004058A (enExample)
PA (1) PA8586601A1 (enExample)
PE (1) PE20040777A1 (enExample)
PL (1) PL376218A1 (enExample)
TN (1) TNSN05111A1 (enExample)
UY (1) UY28024A1 (enExample)
WO (1) WO2004035575A1 (enExample)
ZA (1) ZA200502411B (enExample)

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EP1713504B1 (en) * 2004-01-30 2017-06-07 Zoetis Services LLC Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
ES2296131T3 (es) * 2004-02-02 2008-04-16 Pfizer Products Incorporated Procedimiento para la preparacion de 1-(2s,3s)-2-bencidril-n-(5-terc-butil-2-metoxibencil)quinuclidin-3-amina.
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EA030606B1 (ru) 2006-05-04 2018-08-31 Бёрингер Ингельхайм Интернациональ Гмбх Способы приготовления лекарственного средства, содержащего полиморфы
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
KR101819609B1 (ko) 2010-05-05 2018-01-17 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
MX366629B (es) 2011-07-15 2019-07-17 Boehringer Ingelheim Int Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
JP6218811B2 (ja) 2012-05-14 2017-10-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
US10155000B2 (en) 2016-06-10 2018-12-18 Boehringer Ingelheim International Gmbh Medical use of pharmaceutical combination or composition
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法
CN108341811A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 马罗皮坦杂质的制备方法
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5162339A (en) * 1988-11-23 1992-11-10 Pfizer Inc. Quinuclidine therapeutic agents
CN1067428A (zh) * 1991-05-31 1992-12-30 美国辉瑞有限公司 奎宁环衍生物
CN1068571A (zh) * 1991-05-22 1993-02-03 美国辉瑞有限公司 取代的3-氨基奎宁环
CN1091134A (zh) * 1992-11-12 1994-08-24 美国辉瑞有限公司 治疗炎症和胃肠疾病的奎宁环衍生物
US5604241A (en) * 1992-10-21 1997-02-18 Pfizer Inc. Substituted benzylaminoquinuclidines as substance P antagonists

Family Cites Families (9)

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US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
US4680283A (en) 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
US5138060A (en) 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
EP1114823A3 (en) 1992-08-19 2001-07-18 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
JP2656699B2 (ja) 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
JP2656700B2 (ja) 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
IL109646A0 (en) 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
MX9706944A (es) 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162339A (en) * 1988-11-23 1992-11-10 Pfizer Inc. Quinuclidine therapeutic agents
CN1068571A (zh) * 1991-05-22 1993-02-03 美国辉瑞有限公司 取代的3-氨基奎宁环
CN1067428A (zh) * 1991-05-31 1992-12-30 美国辉瑞有限公司 奎宁环衍生物
US5604241A (en) * 1992-10-21 1997-02-18 Pfizer Inc. Substituted benzylaminoquinuclidines as substance P antagonists
CN1091134A (zh) * 1992-11-12 1994-08-24 美国辉瑞有限公司 治疗炎症和胃肠疾病的奎宁环衍生物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
'Quinuclidine-based NK-1 antagonistsI:3-benzyloxy-1-azabicyclo?.2.2üoctanes'. SEWARD E.M. ET AL.BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS,Vol.3 No.6. 1993
'Quinuclidine-based NK-1 antagonistsI:3-benzyloxy-1-azabicyclo?.2.2üoctanes'. SEWARD E.M. ET AL.BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS,Vol.3 No.6. 1993 *

Also Published As

Publication number Publication date
CA2500635A1 (en) 2004-04-29
PE20040777A1 (es) 2004-11-20
AR041587A1 (es) 2005-05-26
US20050085641A1 (en) 2005-04-21
US20040116704A1 (en) 2004-06-17
IS7755A (is) 2005-03-17
CN1705664A (zh) 2005-12-07
PA8586601A1 (es) 2005-02-04
UY28024A1 (es) 2004-05-31
HRP20050328A2 (en) 2005-06-30
MXPA05004058A (es) 2005-06-08
AU2003277353B2 (en) 2007-08-09
BR0315335A (pt) 2005-08-16
KR20050083764A (ko) 2005-08-26
WO2004035575A1 (en) 2004-04-29
TNSN05111A1 (en) 2007-05-14
KR100739901B1 (ko) 2007-07-13
HK1078087A1 (en) 2006-03-03
EA008192B1 (ru) 2007-04-27
AP2005003288A0 (en) 2005-06-30
US6861526B2 (en) 2005-03-01
JP2006506368A (ja) 2006-02-23
EP1551833A1 (en) 2005-07-13
EP1551833A4 (en) 2010-06-02
PL376218A1 (en) 2005-12-27
EA200500650A1 (ru) 2005-10-27
ZA200502411B (en) 2006-05-31
WO2004035575A8 (en) 2005-05-12
AU2003277353A1 (en) 2004-05-04

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