AU2003277353B2 - Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine - Google Patents

Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine Download PDF

Info

Publication number
AU2003277353B2
AU2003277353B2 AU2003277353A AU2003277353A AU2003277353B2 AU 2003277353 B2 AU2003277353 B2 AU 2003277353B2 AU 2003277353 A AU2003277353 A AU 2003277353A AU 2003277353 A AU2003277353 A AU 2003277353A AU 2003277353 B2 AU2003277353 B2 AU 2003277353B2
Authority
AU
Australia
Prior art keywords
acid
salt
organic
benzhydryl
quinuclidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003277353A
Other languages
English (en)
Other versions
AU2003277353A1 (en
Inventor
Thomas C. Nugent
Robert Seemayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
DSM Pharmaceuticals Inc
Original Assignee
Pfizer Products Inc
DSM Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc, DSM Pharmaceuticals Inc filed Critical Pfizer Products Inc
Publication of AU2003277353A1 publication Critical patent/AU2003277353A1/en
Application granted granted Critical
Publication of AU2003277353B2 publication Critical patent/AU2003277353B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003277353A 2002-10-16 2003-10-10 Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine Ceased AU2003277353B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41905102P 2002-10-16 2002-10-16
US60/419,051 2002-10-16
PCT/US2003/032275 WO2004035575A1 (en) 2002-10-16 2003-10-10 Process for the preparation of (s,s)-cis-2-benzhydryl-3-benzylaminoquinuclidine

Publications (2)

Publication Number Publication Date
AU2003277353A1 AU2003277353A1 (en) 2004-05-04
AU2003277353B2 true AU2003277353B2 (en) 2007-08-09

Family

ID=32108014

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003277353A Ceased AU2003277353B2 (en) 2002-10-16 2003-10-10 Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine

Country Status (21)

Country Link
US (2) US6861526B2 (enExample)
EP (1) EP1551833A4 (enExample)
JP (1) JP2006506368A (enExample)
KR (1) KR100739901B1 (enExample)
CN (1) CN100418964C (enExample)
AP (1) AP2005003288A0 (enExample)
AR (1) AR041587A1 (enExample)
AU (1) AU2003277353B2 (enExample)
BR (1) BR0315335A (enExample)
CA (1) CA2500635A1 (enExample)
EA (1) EA008192B1 (enExample)
HR (1) HRP20050328A2 (enExample)
IS (1) IS7755A (enExample)
MX (1) MXPA05004058A (enExample)
PA (1) PA8586601A1 (enExample)
PE (1) PE20040777A1 (enExample)
PL (1) PL376218A1 (enExample)
TN (1) TNSN05111A1 (enExample)
UY (1) UY28024A1 (enExample)
WO (1) WO2004035575A1 (enExample)
ZA (1) ZA200502411B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
HUE034099T2 (en) * 2004-01-30 2018-01-29 Zoetis Services Llc Antimicrobial preservatives for the delivery of multidose formulations using beta-cyclodextrins for liquid dosage forms
DK1713801T3 (da) * 2004-02-02 2008-03-17 Pfizer Prod Inc Fremgangsmåde til fremstilling af 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amin
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EP2382216A1 (en) 2008-12-23 2011-11-02 Boehringer Ingelheim International GmbH Salt forms of organic compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
PH12012502524A1 (en) 2010-06-24 2014-02-10 Boehringer Ingelheim Int Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法
CN108341811A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 马罗皮坦杂质的制备方法
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法
WO2025172911A1 (en) * 2024-02-16 2025-08-21 Teadus Pharmaceuticals Pvt. Ltd A process for the preparation of (2s,3s)-2-benzhydryl- n-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine and pharmaceutically acceptable salts thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
US4680283A (en) 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
MX18467A (es) 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
US5138060A (en) 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
RU2092486C1 (ru) * 1991-05-22 1997-10-10 Пфайзер Инк. Замещенные 3-аминохинуклидины
BR9206073A (pt) 1991-05-31 1994-12-06 Pfizer Derivados de quinuclidina
JP2909214B2 (ja) 1992-08-19 1999-06-23 フアイザー・インコーポレイテツド 置換ベンジルアミノ窒素含有非芳香族複素環化合物
US5604241A (en) * 1992-10-21 1997-02-18 Pfizer Inc. Substituted benzylaminoquinuclidines as substance P antagonists
JP2656699B2 (ja) 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
JP2656700B2 (ja) 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
NZ254604A (en) 1992-11-12 1997-06-24 Pfizer Quinuclidine derivative and pharmaceutical compositions thereof
IL109646A0 (en) 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
MX9706944A (es) 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters, (1993), vol 3, no. 6, pp 1361-1366. *

Also Published As

Publication number Publication date
JP2006506368A (ja) 2006-02-23
EP1551833A4 (en) 2010-06-02
US20050085641A1 (en) 2005-04-21
PA8586601A1 (es) 2005-02-04
MXPA05004058A (es) 2005-06-08
EP1551833A1 (en) 2005-07-13
US6861526B2 (en) 2005-03-01
CN1705664A (zh) 2005-12-07
UY28024A1 (es) 2004-05-31
TNSN05111A1 (en) 2007-05-14
HK1078087A1 (en) 2006-03-03
KR20050083764A (ko) 2005-08-26
WO2004035575A8 (en) 2005-05-12
EA008192B1 (ru) 2007-04-27
PL376218A1 (en) 2005-12-27
BR0315335A (pt) 2005-08-16
CN100418964C (zh) 2008-09-17
WO2004035575A1 (en) 2004-04-29
AR041587A1 (es) 2005-05-26
AP2005003288A0 (en) 2005-06-30
PE20040777A1 (es) 2004-11-20
EA200500650A1 (ru) 2005-10-27
CA2500635A1 (en) 2004-04-29
US20040116704A1 (en) 2004-06-17
IS7755A (is) 2005-03-17
ZA200502411B (en) 2006-05-31
HRP20050328A2 (en) 2005-06-30
AU2003277353A1 (en) 2004-05-04
KR100739901B1 (ko) 2007-07-13

Similar Documents

Publication Publication Date Title
US6861526B2 (en) Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
EP3956292B1 (en) A process for the preparation of enantiomerically pure norepinephrine
SK164597A3 (en) Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid
HU226475B1 (en) Process for producing (1r,4s)- and (1s,4r)-1-amino-4-hydroxymethyl-2-cyclopentene and the new intermediates
HU216629B (hu) Eljárás 1-aza-biciklo[2.2.2]okt-3-il származékok előállítására
EP3022183A1 (en) Method of racemisation of undesired enantiomers
KR100812046B1 (ko) 1-(2ｓ,3ｓ)-2-벤즈히드릴-ｎ-(5-삼급-부틸-2-메톡시벤질)퀴누클리딘-3-아민의 제조 방법
JP2898758B2 (ja) ２−（１−アザビシクロ〔２．２．２〕−オクタ−３−イル）−２，４，５，６−テトラヒドロ−１Ｈ−ベンザ〔ｄｅ〕イソキノリン−１−オン及び中間生成物の製造方法
US8524936B2 (en) Manufacturing process for sitagliptin from L-aspartic acid
JPH0757747B2 (ja) フィソスチグミンの製造における中間体として使用されるアルキル化オキシインドールのエナンチオ選択的合成方法
JP2843759B2 (ja) フィゾスチグミンの製造に使用される中間体のエナンチオ選択的合成法
CN1213991C (zh) 偏亚环己基胺顺式选择性催化加氢工艺
CZ20011465A3 (cs) Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin
HK1078087B (en) Process for the preparation of (s,s)-cis-2-benzhydryl-3-benzylaminoquinuclidine
CN1989097A (zh) 用于制备非对映异构体富集的化合物的方法
CN1295555A (zh) Hpb酯类化合物的制备方法
JP2003171354A (ja) 光学活性アミン化合物又はその塩の製造方法
SK287537B6 (sk) Spôsob výroby N,N-diizopropyl-3-(2-hydroxy-5-metylfenyl)-3- fenylpropylamínu v jeho racemickej alebo opticky aktívnej forme
JPH08253497A (ja) ペプチド型化合物
CN121358709A (zh) 用于制备5-{2-[苄基-(1-(4-羟基苯基)-1-甲基乙基)氨基]-1-羟基乙基}苯-1,3-二醇半富马酸盐的方法
JP2005075754A (ja) トランス−１，２−ビス（３，５−ジメチルフェニル）−１，２−エタンジアミンの光学分割方法
KR980009228A (ko) 에페드린계 화합물의 입체선택적 제조 방법
MXPA06008441A (en) Process for preparation of 1-(2s, 3s)-2-benzhydryl-n -(5-tert-butyl-2 -methoxybenzyl) quinuclidin-3 -amine

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired