CN100374565C - 用于epothilone生物合成的基因 - Google Patents
用于epothilone生物合成的基因 Download PDFInfo
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- CN100374565C CN100374565C CNB998074217A CN99807421A CN100374565C CN 100374565 C CN100374565 C CN 100374565C CN B998074217 A CNB998074217 A CN B998074217A CN 99807421 A CN99807421 A CN 99807421A CN 100374565 C CN100374565 C CN 100374565C
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- epothilone
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9950498A | 1998-06-18 | 1998-06-18 | |
| US09/099,504 | 1998-06-18 | ||
| US10163198P | 1998-09-24 | 1998-09-24 | |
| US60/101,631 | 1998-09-24 | ||
| US11890699P | 1999-02-05 | 1999-02-05 | |
| US60/118,906 | 1999-02-05 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100637938A Division CN100374566C (zh) | 1998-06-18 | 1999-06-16 | 用于epothilone生物合成的基因 |
| CNA2007100890997A Division CN101161817A (zh) | 1998-06-18 | 1999-06-16 | 用于epothilone生物合成的基因 |
Publications (2)
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| CN1305530A CN1305530A (zh) | 2001-07-25 |
| CN100374565C true CN100374565C (zh) | 2008-03-12 |
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| CNB998074217A Expired - Fee Related CN100374565C (zh) | 1998-06-18 | 1999-06-16 | 用于epothilone生物合成的基因 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1088078A2 (ko) |
| JP (3) | JP2002518004A (ko) |
| KR (1) | KR100511233B1 (ko) |
| CN (1) | CN100374565C (ko) |
| AU (1) | AU753567B2 (ko) |
| BR (1) | BR9911349A (ko) |
| CA (1) | CA2329774A1 (ko) |
| HU (1) | HUP0102186A3 (ko) |
| ID (1) | ID29128A (ko) |
| IL (3) | IL139735A0 (ko) |
| NO (2) | NO20006195L (ko) |
| NZ (1) | NZ508326A (ko) |
| PL (1) | PL200157B1 (ko) |
| SK (1) | SK19242000A3 (ko) |
| TR (1) | TR200003759T2 (ko) |
| WO (1) | WO1999066028A2 (ko) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| DE19846493A1 (de) * | 1998-10-09 | 2000-04-13 | Biotechnolog Forschung Gmbh | DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen |
| JP4662635B2 (ja) | 1998-11-20 | 2011-03-30 | コーサン バイオサイエンシーズ， インコーポレイテッド | エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料 |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| WO2001053533A2 (en) * | 2000-01-21 | 2001-07-26 | Kosan Biosciences, Inc. | Method for cloning polyketide synthase genes |
| US6998256B2 (en) | 2000-04-28 | 2006-02-14 | Kosan Biosciences, Inc. | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate |
| ATE309369T1 (de) * | 2000-04-28 | 2005-11-15 | Kosan Biosciences Inc | Heterologe herstellung von polyketiden |
| IL155306A0 (en) | 2000-10-13 | 2003-11-23 | Univ Mississippi | Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby |
| US7257562B2 (en) | 2000-10-13 | 2007-08-14 | Thallion Pharmaceuticals Inc. | High throughput method for discovery of gene clusters |
| SI1483251T1 (sl) | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| US7767399B2 (en) * | 2005-01-31 | 2010-08-03 | Merck & Co., Inc. | Purification process for plasmid DNA |
| DK2668284T3 (en) | 2011-01-28 | 2014-12-15 | Amyris Inc | Screening of colony micro encapsulated in gel |
| MX2013013065A (es) | 2011-05-13 | 2013-12-02 | Amyris Inc | Metodos y composiciones para detectar la produccion microbiana de compuestos inmiscibles em agua. |
| BR112015002724B1 (pt) | 2012-08-07 | 2022-02-01 | Total Marketing Services | Método para produzir um composto não catabólico heterólogo, e, composição de fermentação |
| BR112015023089A2 (pt) | 2013-03-15 | 2017-11-21 | Amyris Inc | célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coa |
| CN105934517A (zh) | 2013-08-07 | 2016-09-07 | 阿迈瑞斯公司 | 用于稳定生产乙酰辅酶a衍生化合物的方法 |
| AU2016284689B9 (en) | 2015-06-25 | 2022-01-20 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
| CN106916834B (zh) * | 2015-12-24 | 2022-08-05 | 武汉合生科技有限公司 | 化合物的生物合成基因簇及其应用 |
| CN111138444B (zh) * | 2020-01-08 | 2022-05-03 | 山东大学 | 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022461A1 (de) * | 1996-11-18 | 1998-05-28 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel |
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1998
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1999
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- 1999-06-16 TR TR2000/03759T patent/TR200003759T2/xx unknown
- 1999-06-16 JP JP2000554837A patent/JP2002518004A/ja not_active Withdrawn
- 1999-06-16 EP EP99929243A patent/EP1088078A2/en not_active Withdrawn
- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/sk not_active Application Discontinuation
- 1999-06-16 CA CA002329774A patent/CA2329774A1/en not_active Abandoned
- 1999-06-16 BR BR9911349-0A patent/BR9911349A/pt not_active Application Discontinuation
- 1999-06-16 IL IL13973599A patent/IL139735A0/xx unknown
- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/en active Application Filing
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/hu unknown
- 1999-06-16 KR KR10-2000-7014348A patent/KR100511233B1/ko not_active IP Right Cessation
- 1999-06-16 PL PL345579A patent/PL200157B1/pl not_active IP Right Cessation
- 1999-06-16 AU AU46116/99A patent/AU753567B2/en not_active Ceased
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2000
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2005
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2007
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022461A1 (de) * | 1996-11-18 | 1998-05-28 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel |
Non-Patent Citations (2)
| Title |
|---|
| A Sorangium cellulosum (Myxobacterium) Gene Cluster for theBiosynthesis of the Macrolide antibiotic soraphenA:Cloning,characterization,and homology to polyketidesynthase genes from actinomycetes. Thomas Schupp et al.Journal of Bacteriology,Vol.177 No.13. 1995 * |
| Towards the synthesis of epothilone A:enantioselectivepreparation of the thiazole sidechain and macrocyclic ringclosure. Richard E et al.Tetrahedron Letters,Vol.38 No.12. 1997 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL139735A0 (en) | 2002-02-10 |
| HUP0102186A2 (hu) | 2001-10-28 |
| KR100511233B1 (ko) | 2005-08-31 |
| NZ508326A (en) | 2003-10-31 |
| NO20006195L (no) | 2001-02-16 |
| IL190391A0 (en) | 2008-11-03 |
| WO1999066028A3 (en) | 2000-06-29 |
| AU4611699A (en) | 2000-01-05 |
| WO1999066028A2 (en) | 1999-12-23 |
| CN1305530A (zh) | 2001-07-25 |
| TR200003759T2 (tr) | 2001-06-21 |
| PL345579A1 (en) | 2001-12-17 |
| NO20091055L (no) | 2001-02-16 |
| BR9911349A (pt) | 2001-03-13 |
| HUP0102186A3 (en) | 2005-10-28 |
| JP2008092958A (ja) | 2008-04-24 |
| JP2002518004A (ja) | 2002-06-25 |
| ID29128A (id) | 2001-08-02 |
| IL139735A (en) | 2009-06-15 |
| KR20010052962A (ko) | 2001-06-25 |
| CA2329774A1 (en) | 1999-12-23 |
| AU753567B2 (en) | 2002-10-24 |
| PL200157B1 (pl) | 2008-12-31 |
| JP2006061166A (ja) | 2006-03-09 |
| SK19242000A3 (sk) | 2001-07-10 |
| NO20006195D0 (no) | 2000-12-06 |
| EP1088078A2 (en) | 2001-04-04 |
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