PL345579A1 - Genes for the biosynthesis of epothilones - Google Patents

Genes for the biosynthesis of epothilones

Info

Publication number
PL345579A1
PL345579A1 PL99345579A PL34557999A PL345579A1 PL 345579 A1 PL345579 A1 PL 345579A1 PL 99345579 A PL99345579 A PL 99345579A PL 34557999 A PL34557999 A PL 34557999A PL 345579 A1 PL345579 A1 PL 345579A1
Authority
PL
Poland
Prior art keywords
epothilones
biosynthesis
genes
Prior art date
Application number
PL99345579A
Other versions
PL200157B1 (en
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Jorn Gorlach
Devon Cyr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL345579A1 publication Critical patent/PL345579A1/en
Publication of PL200157B1 publication Critical patent/PL200157B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PL345579A 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones PL200157B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (2)

Publication Number Publication Date
PL345579A1 true PL345579A1 (en) 2001-12-17
PL200157B1 PL200157B1 (en) 2008-12-31

Family

ID=27378840

Family Applications (1)

Application Number Title Priority Date Filing Date
PL345579A PL200157B1 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Country Status (16)

Country Link
EP (1) EP1088078A2 (en)
JP (3) JP2002518004A (en)
KR (1) KR100511233B1 (en)
CN (1) CN100374565C (en)
AU (1) AU753567B2 (en)
BR (1) BR9911349A (en)
CA (1) CA2329774A1 (en)
HU (1) HUP0102186A3 (en)
ID (1) ID29128A (en)
IL (3) IL139735A0 (en)
NO (2) NO20006195L (en)
NZ (1) NZ508326A (en)
PL (1) PL200157B1 (en)
SK (1) SK19242000A3 (en)
TR (1) TR200003759T2 (en)
WO (1) WO1999066028A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69734362T2 (en) 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research SYNTHESIS OF EPOTHILONES, INTERMEDIATE PRODUCTS, ANALOGUES AND USES THEREOF
FR2775187B1 (en) 1998-02-25 2003-02-21 Novartis Ag USE OF EPOTHILONE B FOR THE MANUFACTURE OF AN ANTIPROLIFERATIVE PHARMACEUTICAL PREPARATION AND A COMPOSITION COMPRISING EPOTHILONE B AS AN IN VIVO ANTIPROLIFERATIVE AGENT
DE19846493A1 (en) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA sequence coding for products involved in the biosynthesis of polyketide or heteropolyketide compounds, especially epothilone
CA2350189A1 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US20030113715A1 (en) * 2000-01-21 2003-06-19 Daniel Santi Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
ATE309369T1 (en) * 2000-04-28 2005-11-15 Kosan Biosciences Inc HETEROLOGUE PRODUCTION OF POLYKETIDES
WO2002030356A2 (en) 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
ES2337134T3 (en) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company DERIVATIVES OF C3-CIANO-EPOTILONE.
EP1856262B1 (en) * 2005-01-31 2012-08-15 Merck Sharp & Dohme Corp. Upstream and a downstream purification process for large scale production of plasmid dna
WO2012103516A1 (en) 2011-01-28 2012-08-02 Amyris, Inc. Gel-encapsulated microcolony screening
CN103518136A (en) 2011-05-13 2014-01-15 阿迈瑞斯公司 Methods and compositions for detecting microbial production of water-immiscible compounds
BR112015002724B1 (en) 2012-08-07 2022-02-01 Total Marketing Services Method for producing a heterologous non-catabolic compound, and, fermentation composition
JP6595449B2 (en) 2013-03-15 2019-10-23 アミリス， インコーポレイテッド Use of phosphoketolase and phosphotransacetylase to produce acetyl coenzyme A derived compounds
WO2015020649A1 (en) 2013-08-07 2015-02-12 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210350A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (en) * 2015-12-24 2022-08-05 武汉合生科技有限公司 Biosynthetic gene cluster of compounds and application thereof
CN111138444B (en) * 2020-01-08 2022-05-03 山东大学 Epothilone B glucoside compounds and enzymatic preparation and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335383A (en) * 1996-11-18 2000-10-27 Biotechnolog Forschung Gmbh Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells

Also Published As

Publication number Publication date
SK19242000A3 (en) 2001-07-10
KR100511233B1 (en) 2005-08-31
TR200003759T2 (en) 2001-06-21
JP2008092958A (en) 2008-04-24
CN100374565C (en) 2008-03-12
CA2329774A1 (en) 1999-12-23
NZ508326A (en) 2003-10-31
KR20010052962A (en) 2001-06-25
NO20006195L (en) 2001-02-16
IL190391A0 (en) 2008-11-03
WO1999066028A3 (en) 2000-06-29
HUP0102186A3 (en) 2005-10-28
IL139735A0 (en) 2002-02-10
EP1088078A2 (en) 2001-04-04
PL200157B1 (en) 2008-12-31
AU4611699A (en) 2000-01-05
BR9911349A (en) 2001-03-13
NO20006195D0 (en) 2000-12-06
HUP0102186A2 (en) 2001-10-28
CN1305530A (en) 2001-07-25
JP2002518004A (en) 2002-06-25
WO1999066028A2 (en) 1999-12-23
ID29128A (en) 2001-08-02
JP2006061166A (en) 2006-03-09
NO20091055L (en) 2001-02-16
IL139735A (en) 2009-06-15
AU753567B2 (en) 2002-10-24

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Legal Events

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LAPS Decisions on the lapse of the protection rights

Effective date: 20140616