HUP0102186A3 - Genes for the biosynthesis of epothilones - Google Patents
Genes for the biosynthesis of epothilonesInfo
- Publication number
- HUP0102186A3 HUP0102186A3 HU0102186A HUP0102186A HUP0102186A3 HU P0102186 A3 HUP0102186 A3 HU P0102186A3 HU 0102186 A HU0102186 A HU 0102186A HU P0102186 A HUP0102186 A HU P0102186A HU P0102186 A3 HUP0102186 A3 HU P0102186A3
- Authority
- HU
- Hungary
- Prior art keywords
- epothilones
- biosynthesis
- genes
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229930013356 epothilone Natural products 0.000 title 1
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9950498A | 1998-06-18 | 1998-06-18 | |
| US10163198P | 1998-09-24 | 1998-09-24 | |
| US11890699P | 1999-02-05 | 1999-02-05 | |
| PCT/EP1999/004171 WO1999066028A2 (en) | 1998-06-18 | 1999-06-16 | Genes for the biosynthesis of epothilones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102186A2 HUP0102186A2 (hu) | 2001-10-28 |
| HUP0102186A3 true HUP0102186A3 (en) | 2005-10-28 |
Family
ID=27378840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102186A HUP0102186A3 (en) | 1998-06-18 | 1999-06-16 | Genes for the biosynthesis of epothilones |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1088078A2 (hu) |
| JP (3) | JP2002518004A (hu) |
| KR (1) | KR100511233B1 (hu) |
| CN (1) | CN100374565C (hu) |
| AU (1) | AU753567B2 (hu) |
| BR (1) | BR9911349A (hu) |
| CA (1) | CA2329774A1 (hu) |
| HU (1) | HUP0102186A3 (hu) |
| ID (1) | ID29128A (hu) |
| IL (3) | IL139735A0 (hu) |
| NO (2) | NO20006195L (hu) |
| NZ (1) | NZ508326A (hu) |
| PL (1) | PL200157B1 (hu) |
| SK (1) | SK19242000A3 (hu) |
| TR (1) | TR200003759T2 (hu) |
| WO (1) | WO1999066028A2 (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69734362T2 (de) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| DE19846493A1 (de) * | 1998-10-09 | 2000-04-13 | Biotechnolog Forschung Gmbh | DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| NZ511722A (en) * | 1998-11-20 | 2004-05-28 | Kosan Biosciences Inc | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| WO2001053533A2 (en) * | 2000-01-21 | 2001-07-26 | Kosan Biosciences, Inc. | Method for cloning polyketide synthase genes |
| KR20070092334A (ko) * | 2000-04-28 | 2007-09-12 | 코산 바이오사이언시즈, 인코포레이티드 | 폴리케타이드의 제조방법 |
| US6998256B2 (en) | 2000-04-28 | 2006-02-14 | Kosan Biosciences, Inc. | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate |
| JP2005500974A (ja) | 2000-10-13 | 2005-01-13 | ザ ユニバーシテイ オブ ミシシッピー | エポシロン類及び関連類似体の合成 |
| US7257562B2 (en) | 2000-10-13 | 2007-08-14 | Thallion Pharmaceuticals Inc. | High throughput method for discovery of gene clusters |
| DK1483251T3 (da) | 2002-03-12 | 2010-04-12 | Bristol Myers Squibb Co | C3-cyano-epothilon-derivater |
| CA2595594C (en) * | 2005-01-31 | 2012-05-01 | Merck & Co., Inc. | Upstream and a downstream purification process for large scale production of plasmid dna |
| WO2012103516A1 (en) | 2011-01-28 | 2012-08-02 | Amyris, Inc. | Gel-encapsulated microcolony screening |
| SG194785A1 (en) | 2011-05-13 | 2013-12-30 | Amyris Inc | Methods and compositions for detecting microbial production of water-immiscible compounds |
| BR112015002724B1 (pt) | 2012-08-07 | 2022-02-01 | Total Marketing Services | Método para produzir um composto não catabólico heterólogo, e, composição de fermentação |
| EP2971027B1 (en) | 2013-03-15 | 2019-01-30 | Amyris, Inc. | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
| BR112016002526B1 (pt) | 2013-08-07 | 2021-11-23 | Total Marketing Services | Método para produção de um composto heterólogo não catabólico, e, composição de fermentação |
| WO2016210350A1 (en) | 2015-06-25 | 2016-12-29 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
| CN106916834B (zh) * | 2015-12-24 | 2022-08-05 | 武汉合生科技有限公司 | 化合物的生物合成基因簇及其应用 |
| CN111138444B (zh) * | 2020-01-08 | 2022-05-03 | 山东大学 | 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU229833B1 (en) * | 1996-11-18 | 2014-09-29 | Biotechnolog Forschung Gmbh | Epothilone d production process, and its use as cytostatic as well as phytosanitary agents |
-
1998
- 1998-06-12 NZ NZ508326A patent/NZ508326A/en not_active IP Right Cessation
-
1999
- 1999-06-16 EP EP99929243A patent/EP1088078A2/en not_active Withdrawn
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/hu unknown
- 1999-06-16 PL PL345579A patent/PL200157B1/pl not_active IP Right Cessation
- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/en active Application Filing
- 1999-06-16 TR TR2000/03759T patent/TR200003759T2/xx unknown
- 1999-06-16 BR BR9911349-0A patent/BR9911349A/pt not_active Application Discontinuation
- 1999-06-16 ID IDW20002594A patent/ID29128A/id unknown
- 1999-06-16 AU AU46116/99A patent/AU753567B2/en not_active Ceased
- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/sk not_active Application Discontinuation
- 1999-06-16 IL IL13973599A patent/IL139735A0/xx unknown
- 1999-06-16 JP JP2000554837A patent/JP2002518004A/ja not_active Withdrawn
- 1999-06-16 CA CA002329774A patent/CA2329774A1/en not_active Abandoned
- 1999-06-16 CN CNB998074217A patent/CN100374565C/zh not_active Expired - Fee Related
- 1999-06-16 KR KR10-2000-7014348A patent/KR100511233B1/ko not_active IP Right Cessation
-
2000
- 2000-11-16 IL IL139735A patent/IL139735A/en not_active IP Right Cessation
- 2000-12-06 NO NO20006195A patent/NO20006195L/no unknown
-
2005
- 2005-10-20 JP JP2005305998A patent/JP2006061166A/ja active Pending
-
2007
- 2007-12-26 JP JP2007334606A patent/JP2008092958A/ja active Pending
-
2008
- 2008-03-24 IL IL190391A patent/IL190391A0/en unknown
-
2009
- 2009-03-09 NO NO20091055A patent/NO20091055L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9911349A (pt) | 2001-03-13 |
| JP2006061166A (ja) | 2006-03-09 |
| WO1999066028A2 (en) | 1999-12-23 |
| EP1088078A2 (en) | 2001-04-04 |
| IL139735A (en) | 2009-06-15 |
| NO20006195L (no) | 2001-02-16 |
| KR20010052962A (ko) | 2001-06-25 |
| IL190391A0 (en) | 2008-11-03 |
| WO1999066028A3 (en) | 2000-06-29 |
| SK19242000A3 (sk) | 2001-07-10 |
| HUP0102186A2 (hu) | 2001-10-28 |
| JP2008092958A (ja) | 2008-04-24 |
| NZ508326A (en) | 2003-10-31 |
| ID29128A (id) | 2001-08-02 |
| NO20091055L (no) | 2001-02-16 |
| NO20006195D0 (no) | 2000-12-06 |
| CA2329774A1 (en) | 1999-12-23 |
| PL345579A1 (en) | 2001-12-17 |
| KR100511233B1 (ko) | 2005-08-31 |
| JP2002518004A (ja) | 2002-06-25 |
| AU753567B2 (en) | 2002-10-24 |
| PL200157B1 (pl) | 2008-12-31 |
| IL139735A0 (en) | 2002-02-10 |
| CN100374565C (zh) | 2008-03-12 |
| TR200003759T2 (tr) | 2001-06-21 |
| CN1305530A (zh) | 2001-07-25 |
| AU4611699A (en) | 2000-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |