IL139735A0 - Genes for the biosynthesis of epothilones - Google Patents

Genes for the biosynthesis of epothilones

Info

Publication number
IL139735A0
IL139735A0 IL13973599A IL13973599A IL139735A0 IL 139735 A0 IL139735 A0 IL 139735A0 IL 13973599 A IL13973599 A IL 13973599A IL 13973599 A IL13973599 A IL 13973599A IL 139735 A0 IL139735 A0 IL 139735A0
Authority
IL
Israel
Prior art keywords
epothilones
biosynthesis
genes
Prior art date
Application number
IL13973599A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL139735A0 publication Critical patent/IL139735A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL13973599A 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones IL139735A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (1)

Publication Number Publication Date
IL139735A0 true IL139735A0 (en) 2002-02-10

Family

ID=27378840

Family Applications (3)

Application Number Title Priority Date Filing Date
IL13973599A IL139735A0 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones
IL139735A IL139735A (en) 1998-06-18 2000-11-16 Genes for the biosynthesis of epothilones
IL190391A IL190391A0 (en) 1998-06-18 2008-03-24 Genes for the biosynthesis of epothilones

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL139735A IL139735A (en) 1998-06-18 2000-11-16 Genes for the biosynthesis of epothilones
IL190391A IL190391A0 (en) 1998-06-18 2008-03-24 Genes for the biosynthesis of epothilones

Country Status (16)

Country Link
EP (1) EP1088078A2 (hu)
JP (3) JP2002518004A (hu)
KR (1) KR100511233B1 (hu)
CN (1) CN100374565C (hu)
AU (1) AU753567B2 (hu)
BR (1) BR9911349A (hu)
CA (1) CA2329774A1 (hu)
HU (1) HUP0102186A3 (hu)
ID (1) ID29128A (hu)
IL (3) IL139735A0 (hu)
NO (2) NO20006195L (hu)
NZ (1) NZ508326A (hu)
PL (1) PL200157B1 (hu)
SK (1) SK19242000A3 (hu)
TR (1) TR200003759T2 (hu)
WO (1) WO1999066028A2 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
AU768220B2 (en) 1998-11-20 2003-12-04 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
WO2001053533A2 (en) * 2000-01-21 2001-07-26 Kosan Biosciences, Inc. Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
ES2332727T3 (es) * 2000-04-28 2010-02-11 Kosan Biosciences, Inc. Epotilona d cristalina.
WO2002030356A2 (en) 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
AU2006211216B2 (en) * 2005-01-31 2011-02-03 Merck Sharp & Dohme Llc Purification process for plasmid DNA
AU2012211052A1 (en) 2011-01-28 2013-09-05 Amyris, Inc. Gel-encapsulated microcolony screening
EP2707722A1 (en) 2011-05-13 2014-03-19 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
CA2879178C (en) 2012-08-07 2020-11-24 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
US9410214B2 (en) 2013-03-15 2016-08-09 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme A derived compounds
EP3663392A1 (en) 2013-08-07 2020-06-10 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN108474008A (zh) 2015-06-25 2018-08-31 阿迈瑞斯公司 麦芽糖依赖性降解决定子、麦芽糖响应型启动子、稳定化构建体及其在生成非分解代谢化合物中的用途
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59712968D1 (de) * 1996-11-18 2008-10-30 Biotechnolog Forschung Gmbh Epothilone E und F

Also Published As

Publication number Publication date
AU753567B2 (en) 2002-10-24
AU4611699A (en) 2000-01-05
JP2008092958A (ja) 2008-04-24
SK19242000A3 (sk) 2001-07-10
EP1088078A2 (en) 2001-04-04
ID29128A (id) 2001-08-02
JP2006061166A (ja) 2006-03-09
WO1999066028A3 (en) 2000-06-29
KR100511233B1 (ko) 2005-08-31
CN1305530A (zh) 2001-07-25
TR200003759T2 (tr) 2001-06-21
NO20006195L (no) 2001-02-16
WO1999066028A2 (en) 1999-12-23
HUP0102186A2 (hu) 2001-10-28
IL139735A (en) 2009-06-15
NO20006195D0 (no) 2000-12-06
CA2329774A1 (en) 1999-12-23
NO20091055L (no) 2001-02-16
KR20010052962A (ko) 2001-06-25
HUP0102186A3 (en) 2005-10-28
PL345579A1 (en) 2001-12-17
JP2002518004A (ja) 2002-06-25
BR9911349A (pt) 2001-03-13
IL190391A0 (en) 2008-11-03
CN100374565C (zh) 2008-03-12
NZ508326A (en) 2003-10-31
PL200157B1 (pl) 2008-12-31

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