BR9911349A - Genes para a biossìntese de epotilonas - Google Patents

Genes para a biossìntese de epotilonas

Info

Publication number
BR9911349A
BR9911349A BR9911349-0A BR9911349A BR9911349A BR 9911349 A BR9911349 A BR 9911349A BR 9911349 A BR9911349 A BR 9911349A BR 9911349 A BR9911349 A BR 9911349A
Authority
BR
Brazil
Prior art keywords
genes
epothilone
biosynthesis
epothilone biosynthesis
biosysynthesis
Prior art date
Application number
BR9911349-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Joern Goerlach
Devon Cyr
Original Assignee
Novartis Ag Novartis S A Novar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Novartis S A Novar filed Critical Novartis Ag Novartis S A Novar
Publication of BR9911349A publication Critical patent/BR9911349A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BR9911349-0A 1998-06-18 1999-06-16 Genes para a biossìntese de epotilonas BR9911349A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (1)

Publication Number Publication Date
BR9911349A true BR9911349A (pt) 2001-03-13

Family

ID=27378840

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911349-0A BR9911349A (pt) 1998-06-18 1999-06-16 Genes para a biossìntese de epotilonas

Country Status (16)

Country Link
EP (1) EP1088078A2 (hu)
JP (3) JP2002518004A (hu)
KR (1) KR100511233B1 (hu)
CN (1) CN100374565C (hu)
AU (1) AU753567B2 (hu)
BR (1) BR9911349A (hu)
CA (1) CA2329774A1 (hu)
HU (1) HUP0102186A3 (hu)
ID (1) ID29128A (hu)
IL (3) IL139735A0 (hu)
NO (2) NO20006195L (hu)
NZ (1) NZ508326A (hu)
PL (1) PL200157B1 (hu)
SK (1) SK19242000A3 (hu)
TR (1) TR200003759T2 (hu)
WO (1) WO1999066028A2 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69734362T2 (de) 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
CA2350189A1 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US20030113715A1 (en) * 2000-01-21 2003-06-19 Daniel Santi Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
ATE309369T1 (de) * 2000-04-28 2005-11-15 Kosan Biosciences Inc Heterologe herstellung von polyketiden
WO2002030356A2 (en) 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
EP1856262B1 (en) * 2005-01-31 2012-08-15 Merck Sharp & Dohme Corp. Upstream and a downstream purification process for large scale production of plasmid dna
WO2012103516A1 (en) 2011-01-28 2012-08-02 Amyris, Inc. Gel-encapsulated microcolony screening
CN103518136A (zh) 2011-05-13 2014-01-15 阿迈瑞斯公司 用于检测水不混溶性化合物的微生物生成的方法和组合物
BR112015002724B1 (pt) 2012-08-07 2022-02-01 Total Marketing Services Método para produzir um composto não catabólico heterólogo, e, composição de fermentação
JP6595449B2 (ja) 2013-03-15 2019-10-23 アミリス， インコーポレイテッド アセチル補酵素ａ由来化合物を生産するためのホスホケトラーゼおよびホスホトランスアセチラーゼの使用
WO2015020649A1 (en) 2013-08-07 2015-02-12 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210350A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335383A (en) * 1996-11-18 2000-10-27 Biotechnolog Forschung Gmbh Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells

Also Published As

Publication number Publication date
SK19242000A3 (sk) 2001-07-10
KR100511233B1 (ko) 2005-08-31
TR200003759T2 (tr) 2001-06-21
JP2008092958A (ja) 2008-04-24
CN100374565C (zh) 2008-03-12
CA2329774A1 (en) 1999-12-23
NZ508326A (en) 2003-10-31
KR20010052962A (ko) 2001-06-25
NO20006195L (no) 2001-02-16
IL190391A0 (en) 2008-11-03
WO1999066028A3 (en) 2000-06-29
HUP0102186A3 (en) 2005-10-28
IL139735A0 (en) 2002-02-10
EP1088078A2 (en) 2001-04-04
PL200157B1 (pl) 2008-12-31
AU4611699A (en) 2000-01-05
NO20006195D0 (no) 2000-12-06
HUP0102186A2 (hu) 2001-10-28
CN1305530A (zh) 2001-07-25
JP2002518004A (ja) 2002-06-25
WO1999066028A2 (en) 1999-12-23
PL345579A1 (en) 2001-12-17
ID29128A (id) 2001-08-02
JP2006061166A (ja) 2006-03-09
NO20091055L (no) 2001-02-16
IL139735A (en) 2009-06-15
AU753567B2 (en) 2002-10-24

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10, 24, 25 E 37 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]