NO20091055L - Gener for biosyntesen av epotiloner - Google Patents

Gener for biosyntesen av epotiloner

Info

Publication number
NO20091055L
NO20091055L NO20091055A NO20091055A NO20091055L NO 20091055 L NO20091055 L NO 20091055L NO 20091055 A NO20091055 A NO 20091055A NO 20091055 A NO20091055 A NO 20091055A NO 20091055 L NO20091055 L NO 20091055L
Authority
NO
Norway
Prior art keywords
epothilone
biosynthesis
genes
epothilones
cancer
Prior art date
Application number
NO20091055A
Other languages
English (en)
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Jorn Gorlach
Devon Cyr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20091055L publication Critical patent/NO20091055L/no
Application filed by Novartis Ag filed Critical Novartis Ag

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Nukleinsyremolekyler ble isolert fra Sorangium cellulosum som koder for polypeptider som er nødvendige for biosyntesen av epotilon. Det er omtalt metoder for fremstillingen av epotilonet i rekombinante verter transformert med gener ifølge oppfinnelsen. Epotilonet kan på denne måten bli fremstilt i mengder som er store nok for å muliggjøre rensning av disse og anvendelse i farmasøytiske formuleringer slik som for behandlingen av cancer.
NO20091055A 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner NO20091055L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (1)

Publication Number Publication Date
NO20091055L true NO20091055L (no) 2001-02-16

Family

ID=27378840

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20006195A NO20006195L (no) 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner
NO20091055A NO20091055L (no) 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20006195A NO20006195L (no) 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner

Country Status (16)

Country Link
EP (1) EP1088078A2 (no)
JP (3) JP2002518004A (no)
KR (1) KR100511233B1 (no)
CN (1) CN100374565C (no)
AU (1) AU753567B2 (no)
BR (1) BR9911349A (no)
CA (1) CA2329774A1 (no)
HU (1) HUP0102186A3 (no)
ID (1) ID29128A (no)
IL (3) IL139735A0 (no)
NO (2) NO20006195L (no)
NZ (1) NZ508326A (no)
PL (1) PL200157B1 (no)
SK (1) SK19242000A3 (no)
TR (1) TR200003759T2 (no)
WO (1) WO1999066028A2 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
NZ511722A (en) 1998-11-20 2004-05-28 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US20030113715A1 (en) * 2000-01-21 2003-06-19 Daniel Santi Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
EP1652926B1 (en) * 2000-04-28 2009-09-30 Kosan Biosciences, Inc. Crystalline epothilone d
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
AU2002213248A1 (en) 2000-10-13 2002-04-22 The University Of Mississipi Synthesis of epothilones and relates analogs
DE60330651D1 (en) 2002-03-12 2010-02-04 Bristol Myers Squibb Co C3-cyanoepothilonderivate
CA2595594C (en) * 2005-01-31 2012-05-01 Merck & Co., Inc. Upstream and a downstream purification process for large scale production of plasmid dna
JP2014508516A (ja) 2011-01-28 2014-04-10 アミリス， インコーポレイテッド ゲルに封入されたマイクロコロニーのスクリーニング
MX2013013065A (es) 2011-05-13 2013-12-02 Amyris Inc Metodos y composiciones para detectar la produccion microbiana de compuestos inmiscibles em agua.
CN104540949B (zh) 2012-08-07 2018-05-29 阿迈瑞斯公司 用于稳定乙酰-辅酶a衍生化合物生成的方法
AU2014227811C1 (en) 2013-03-15 2018-09-27 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
CA2918891C (en) 2013-08-07 2023-03-14 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210343A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT941227E (pt) * 1996-11-18 2004-08-31 Biotechnolog Forschung Mbh Gbf Epothilona d sua preparacao e sua utilizacao como agente citostatico ou como agente de proteccao fitossanitaria

Also Published As

Publication number Publication date
HUP0102186A3 (en) 2005-10-28
CN100374565C (zh) 2008-03-12
KR20010052962A (ko) 2001-06-25
WO1999066028A2 (en) 1999-12-23
NO20006195D0 (no) 2000-12-06
CA2329774A1 (en) 1999-12-23
JP2008092958A (ja) 2008-04-24
NZ508326A (en) 2003-10-31
HUP0102186A2 (hu) 2001-10-28
EP1088078A2 (en) 2001-04-04
WO1999066028A3 (en) 2000-06-29
BR9911349A (pt) 2001-03-13
AU4611699A (en) 2000-01-05
ID29128A (id) 2001-08-02
PL345579A1 (en) 2001-12-17
NO20006195L (no) 2001-02-16
JP2006061166A (ja) 2006-03-09
KR100511233B1 (ko) 2005-08-31
CN1305530A (zh) 2001-07-25
JP2002518004A (ja) 2002-06-25
IL190391A0 (en) 2008-11-03
IL139735A (en) 2009-06-15
AU753567B2 (en) 2002-10-24
PL200157B1 (pl) 2008-12-31
TR200003759T2 (tr) 2001-06-21
SK19242000A3 (sk) 2001-07-10
IL139735A0 (en) 2002-02-10

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