CN100374551C - 含有病毒的组合物以及浓缩病毒制剂的方法 - Google Patents

含有病毒的组合物以及浓缩病毒制剂的方法 Download PDF

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Publication number
CN100374551C
CN100374551C CNB998050989A CN99805098A CN100374551C CN 100374551 C CN100374551 C CN 100374551C CN B998050989 A CNB998050989 A CN B998050989A CN 99805098 A CN99805098 A CN 99805098A CN 100374551 C CN100374551 C CN 100374551C
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China
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concentration
composition
virus
adenovirus
sup
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Expired - Fee Related
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CNB998050989A
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English (en)
Chinese (zh)
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CN1297478A (zh
Inventor
A·弗雷
H·K·H·克万
V·E·桑德维斯
G·J·维勒坎普
P·-H·袁
小·L·L·邦多克
F·W·波尔特尔四世
J·C·-T·唐
P·伊纳特
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB998050989A 1998-02-17 1999-02-12 含有病毒的组合物以及浓缩病毒制剂的方法 Expired - Fee Related CN100374551C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2446298A 1998-02-17 1998-02-17
US09/024462 1998-02-17
US7964398A 1998-05-15 1998-05-15
US09/079643 1998-05-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2007101670867A Division CN101164623B (zh) 1998-02-17 1999-02-12 浓缩病毒制剂的方法

Publications (2)

Publication Number Publication Date
CN1297478A CN1297478A (zh) 2001-05-30
CN100374551C true CN100374551C (zh) 2008-03-12

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CNB998050989A Expired - Fee Related CN100374551C (zh) 1998-02-17 1999-02-12 含有病毒的组合物以及浓缩病毒制剂的方法
CN2007101670867A Expired - Fee Related CN101164623B (zh) 1998-02-17 1999-02-12 浓缩病毒制剂的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2007101670867A Expired - Fee Related CN101164623B (zh) 1998-02-17 1999-02-12 浓缩病毒制剂的方法

Country Status (24)

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EP (4) EP1054955B1 (https=)
JP (3) JP4358434B2 (https=)
KR (5) KR100912362B1 (https=)
CN (2) CN100374551C (https=)
AR (3) AR020054A1 (https=)
AT (3) ATE371020T1 (https=)
AU (1) AU757976B2 (https=)
BR (1) BR9908015A (https=)
CA (2) CA2723040A1 (https=)
CO (1) CO4820440A1 (https=)
DE (3) DE69942708D1 (https=)
DK (1) DK1054955T3 (https=)
ES (2) ES2290613T3 (https=)
HU (1) HU226015B1 (https=)
ID (1) ID28298A (https=)
IL (2) IL137510A0 (https=)
MY (1) MY141641A (https=)
NO (1) NO20004104L (https=)
PE (1) PE20000265A1 (https=)
PL (1) PL197747B1 (https=)
PT (1) PT1054955E (https=)
SK (1) SK11842000A3 (https=)
TW (1) TWI232107B (https=)
WO (1) WO1999041416A2 (https=)

Cited By (1)

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CN103492557A (zh) * 2011-04-29 2014-01-01 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法

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US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
EP2420247A1 (en) 2000-03-07 2012-02-22 Merck Sharp & Dohme Corp. Adenovirus formulations
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
US20020064860A1 (en) 2000-11-29 2002-05-30 Schering Corporation Method for purifying adenoviruses
JP2002241311A (ja) * 2000-12-12 2002-08-28 Japan Tobacco Inc 界面活性剤を含む医薬組成物
EP1453536A4 (en) 2001-12-12 2009-08-26 Mayne Pharma Int Pty Ltd COMPOSITION FOR PRESERVING VIRUSES
US20030153065A1 (en) * 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
AR038153A1 (es) * 2002-01-18 2004-12-29 Schering Ag Formulaciones estabilizadas de adenovirus
NZ548495A (en) 2004-02-23 2009-05-31 Crucell Holland Bv Virus purification methods
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CN1961961B (zh) * 2005-11-11 2010-05-26 深圳市源兴生物医药科技有限公司 一种药物制剂及其制备方法
DE602006019916D1 (de) 2005-12-12 2011-03-10 Canji Inc Adenovirale expressionsvektoren mit einer expressionskassette im e1-bereich und einer inaktivierten e2b-polymerase
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CN107847581B (zh) 2015-07-07 2022-03-22 扬森疫苗与预防公司 稳定化的可溶性融合前rsv f多肽
ES2839880T3 (es) 2015-07-07 2021-07-06 Janssen Vaccines & Prevention Bv Vacuna contra el VRS
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KR102500970B1 (ko) 2016-04-05 2023-02-17 얀센 백신스 앤드 프리벤션 비.브이. Rsv에 대한 백신
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WO2019021305A1 (en) * 2017-07-24 2019-01-31 Ella Foundation VACCINE AGAINST FOOT AND MOUTH DISEASE
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DD299213A7 (de) * 1988-05-04 1992-04-09 Saechsische Landesgewerbefoerderungsgesellschaft M.B.H.,De Verfahren zur stabilisierung eines lebendvirusimpfstoffes gegen temperatureinwirkung
WO1997023238A1 (fr) * 1995-12-22 1997-07-03 Pasteur Merieux Serums & Vaccins Stabilisants pour vaccins vivants
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US4147772A (en) * 1976-02-03 1979-04-03 Merck & Co., Inc. Vaccine stabilizer
DD299213A7 (de) * 1988-05-04 1992-04-09 Saechsische Landesgewerbefoerderungsgesellschaft M.B.H.,De Verfahren zur stabilisierung eines lebendvirusimpfstoffes gegen temperatureinwirkung
WO1997023238A1 (fr) * 1995-12-22 1997-07-03 Pasteur Merieux Serums & Vaccins Stabilisants pour vaccins vivants
WO1997025072A1 (en) * 1996-01-08 1997-07-17 Canji, Inc. Compositions and methods for therapeutic use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492557A (zh) * 2011-04-29 2014-01-01 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法
CN103492557B (zh) * 2011-04-29 2015-07-29 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法

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KR20080065614A (ko) 2008-07-14
CO4820440A1 (es) 1999-07-28
KR100912362B1 (ko) 2009-08-19
EP1526174B1 (en) 2007-08-22
KR100862169B1 (ko) 2008-10-09
CN1297478A (zh) 2001-05-30
ES2290613T3 (es) 2008-02-16
IL137510A0 (en) 2001-07-24
EP1526173A2 (en) 2005-04-27
KR101018992B1 (ko) 2011-03-07
DE69942708D1 (de) 2010-10-07
ATE371020T1 (de) 2007-09-15
AU2653899A (en) 1999-08-30
EP1054955B1 (en) 2006-10-04
DK1054955T3 (da) 2007-01-15
AR020054A1 (es) 2002-04-10
NO20004104D0 (no) 2000-08-16
HU226015B1 (en) 2008-02-28
KR100991683B1 (ko) 2010-11-04
KR20080065615A (ko) 2008-07-14
ATE478945T1 (de) 2010-09-15
TWI232107B (en) 2005-05-11
PL342847A1 (en) 2001-07-16
ES2272053T3 (es) 2007-04-16
MY141641A (en) 2010-05-31
WO1999041416A2 (en) 1999-08-19
CN101164623B (zh) 2012-11-14
CA2320419C (en) 2011-02-08
HUP0100670A3 (en) 2003-10-28
PT1054955E (pt) 2007-01-31
KR20090127947A (ko) 2009-12-14
NO20004104L (no) 2000-10-17
IL137510A (en) 2012-10-31
JP2010213727A (ja) 2010-09-30
ID28298A (id) 2001-05-10
ATE341614T1 (de) 2006-10-15
AR063315A2 (es) 2009-01-21
PL197747B1 (pl) 2008-04-30
SK11842000A3 (sk) 2001-05-10
HK1097413A1 (en) 2007-06-22
DE69936948D1 (de) 2007-10-04
BR9908015A (pt) 2001-04-24
KR100918187B1 (ko) 2009-09-22
AU757976B2 (en) 2003-03-13
CN101164623A (zh) 2008-04-23
HUP0100670A2 (hu) 2001-06-28
EP1054955A2 (en) 2000-11-29
EP1741777A1 (en) 2007-01-10
CA2723040A1 (en) 1999-08-19
CA2320419A1 (en) 1999-08-19
EP1526173B1 (en) 2012-11-21
DE69936948T2 (de) 2008-05-15
EP1526174A3 (en) 2005-08-31
EP1526174A2 (en) 2005-04-27
WO1999041416A3 (en) 1999-11-18
JP4358434B2 (ja) 2009-11-04
HK1028416A1 (en) 2001-02-16
KR20010072547A (ko) 2001-07-31
EP1526173A3 (en) 2005-08-10
PE20000265A1 (es) 2000-04-25
DE69933433T2 (de) 2007-08-23
AR063314A2 (es) 2009-01-21
DE69933433D1 (de) 2006-11-16
KR20090038927A (ko) 2009-04-21
EP1741777B1 (en) 2010-08-25
JP2002503484A (ja) 2002-02-05
JP2006166925A (ja) 2006-06-29
HK1073481A1 (en) 2005-10-07

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