AR038153A1 - Formulaciones estabilizadas de adenovirus - Google Patents
Formulaciones estabilizadas de adenovirusInfo
- Publication number
- AR038153A1 AR038153A1 ARP030100110A ARP030100110A AR038153A1 AR 038153 A1 AR038153 A1 AR 038153A1 AR P030100110 A ARP030100110 A AR P030100110A AR P030100110 A ARP030100110 A AR P030100110A AR 038153 A1 AR038153 A1 AR 038153A1
- Authority
- AR
- Argentina
- Prior art keywords
- adenovirus
- formula
- compositions
- stabilizing
- ionic detergent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
Abstract
Método para estabilizar composiciones que contienen virus transportados por aire, en particular adenovirus, y en particular adenovirus recombinantes, que comprende la adición a las composiciones de un detergente no iónico que comprende un grupo alquilo y un grupo polietilenglicol (PEG). Composiciones farmacéuticas y de otro tipo de adenovirus, en particular adenovirus recombinantes adecuados para los métodos de terapia génica, que comprenden dichos detergentes. Reivindicación 1: Un método para estabilizar una composición que contiene un virus transportado por aire, caracterizado porque comprende la adición a la composición de una cantidad eficaz como estabilizador de un detergente no iónico de la fórmula: R-O(CH2CH2O)x-H, donde X es 4-30 y R es alquilo lineal o ramificado de 10-70 átomos de carbono, o de la fórmula (1) donde R es -CO2R' que tiene entre 10 y 70 carbonos y W + X + Y + Z = 20, donde R' es como se indicó previamente para R, o de la fórmula (3) donde Res como se indicó previamente y X es 5-100, Y es 25-75 y Z es 50-100, o de la fórmula (3) donde X es 5-15, el anillo A es fenilo o ciclohexileno y R' es R, indicado previamente, o una combinación de las mismas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34922202P | 2002-01-18 | 2002-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038153A1 true AR038153A1 (es) | 2004-12-29 |
Family
ID=27613260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100110A AR038153A1 (es) | 2002-01-18 | 2003-01-15 | Formulaciones estabilizadas de adenovirus |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20030232018A1 (es) |
| EP (1) | EP1465664A1 (es) |
| JP (1) | JP2005515245A (es) |
| KR (1) | KR20040077878A (es) |
| CN (1) | CN1617745A (es) |
| AR (1) | AR038153A1 (es) |
| BR (1) | BR0306925A (es) |
| CA (1) | CA2469721A1 (es) |
| IL (1) | IL162404A0 (es) |
| MX (1) | MXPA04006995A (es) |
| NO (1) | NO20043418L (es) |
| PE (1) | PE20030851A1 (es) |
| PL (1) | PL371261A1 (es) |
| RU (1) | RU2004125283A (es) |
| TW (1) | TW200307750A (es) |
| UY (1) | UY27614A1 (es) |
| WO (1) | WO2003061708A1 (es) |
| ZA (1) | ZA200406547B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2808556A1 (en) | 2010-09-20 | 2012-03-29 | Crucell Holland B.V. | Therapeutic vaccination against active tuberculosis |
| MX354752B (es) | 2010-09-27 | 2018-03-20 | Janssen Vaccines & Prevention Bv | Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria. |
| TW201233803A (en) | 2010-12-02 | 2012-08-16 | Oncolytics Biotech Inc | Lyophilized viral formulations |
| JP6034798B2 (ja) | 2010-12-02 | 2016-11-30 | オンコリティクス バイオテク，インコーポレーテッド | 液体ウイルス製剤 |
| SG11201405228VA (en) | 2012-03-12 | 2014-11-27 | Crucell Holland Bv | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| CN105431169B (zh) | 2012-03-22 | 2019-04-02 | 扬森疫苗与预防公司 | 抗rsv疫苗 |
| EA035522B1 (ru) | 2013-04-25 | 2020-06-29 | Янссен Вэксинс Энд Превеншн Б.В. | Стабильные растворимые f-полипептиды rsv в конформации "до слияния" |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| EP3283634B1 (en) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| EP3821906A1 (en) | 2015-07-07 | 2021-05-19 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv comprising modified f polypeptide |
| US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| EP3359132B1 (en) * | 2015-10-06 | 2023-08-16 | Janssen Vaccines & Prevention B.V. | Methods for preventing plastic-induced degradation of biologicals |
| PE20190420A1 (es) | 2016-04-05 | 2019-03-19 | Janssen Vaccines And Prevention B V | Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas |
| IL262109B2 (en) | 2016-04-05 | 2023-04-01 | Janssen Vaccines Prevention B V | vaccine against rsv |
| EP3455358B1 (en) | 2016-05-12 | 2020-08-26 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| MY194419A (en) | 2016-05-30 | 2022-11-30 | Janssen Vaccines & Prevention Bv | Stabilized pre-fusion rsv f proteins |
| US11001858B2 (en) | 2016-06-20 | 2021-05-11 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| EP3484506A1 (en) | 2016-07-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| CN110268061B (zh) | 2017-02-09 | 2024-07-16 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
| WO2018210871A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| EP3624844A1 (en) | 2017-05-17 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| MX2020002876A (es) | 2017-09-15 | 2020-07-22 | Janssen Vaccines & Prevention Bv | Metodo para la induccion segura de inmunidad contra el vsr. |
| TW202204380A (zh) | 2020-01-31 | 2022-02-01 | 美商詹森藥物公司 | 用於預防及治療冠狀病毒感染之組合物及方法－sars-cov-2疫苗 |
| WO2022175477A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv fb antigens |
| WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2219241C2 (ru) * | 1993-07-13 | 2003-12-20 | Рон-Пуленк Роре С.А. | Дефектный рекомбинантный аденовирусный вектор (варианты) |
| FR2718150B1 (fr) * | 1994-03-29 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
| CZ438398A3 (cs) * | 1996-07-01 | 1999-03-17 | Rhone-Poulenc Rorer S. A. | Způsob přípravy rekombinantních adenovirů |
| FR2751343B1 (fr) * | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| US6544769B1 (en) * | 1996-12-13 | 2003-04-08 | Schering Corporation | Compostions comprising viruses and methods for concentrating virus preparations |
| WO1999041416A2 (en) * | 1998-02-17 | 1999-08-19 | Schering Corporation | Compositions comprising viruses and methods for concentrating virus preparations |
| US6689600B1 (en) * | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| SI1150712T1 (sl) * | 1999-02-05 | 2009-02-28 | Merck & Co Inc | Pripravek cepiva proti humanem papiloma virusu |
| JP5118798B2 (ja) * | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
-
2003
- 2003-01-15 AR ARP030100110A patent/AR038153A1/es unknown
- 2003-01-15 EP EP03731914A patent/EP1465664A1/en not_active Withdrawn
- 2003-01-15 RU RU2004125283/15A patent/RU2004125283A/ru not_active Application Discontinuation
- 2003-01-15 WO PCT/US2003/001055 patent/WO2003061708A1/en not_active Application Discontinuation
- 2003-01-15 BR BR0306925-7A patent/BR0306925A/pt not_active Application Discontinuation
- 2003-01-15 CN CNA038023423A patent/CN1617745A/zh active Pending
- 2003-01-15 KR KR10-2004-7011108A patent/KR20040077878A/ko not_active Application Discontinuation
- 2003-01-15 CA CA002469721A patent/CA2469721A1/en not_active Abandoned
- 2003-01-15 US US10/342,344 patent/US20030232018A1/en not_active Abandoned
- 2003-01-15 JP JP2003561650A patent/JP2005515245A/ja active Pending
- 2003-01-15 PL PL03371261A patent/PL371261A1/xx not_active Application Discontinuation
- 2003-01-15 MX MXPA04006995A patent/MXPA04006995A/es unknown
- 2003-01-15 IL IL16240403A patent/IL162404A0/xx unknown
- 2003-01-17 UY UY27614A patent/UY27614A1/es not_active Application Discontinuation
- 2003-01-17 TW TW092101013A patent/TW200307750A/zh unknown
- 2003-01-17 PE PE2003000051A patent/PE20030851A1/es not_active Application Discontinuation
-
2004
- 2004-08-17 ZA ZA200406547A patent/ZA200406547B/en unknown
- 2004-08-17 NO NO20043418A patent/NO20043418L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200406547B (en) | 2006-06-24 |
| CN1617745A (zh) | 2005-05-18 |
| NO20043418L (no) | 2004-08-17 |
| UY27614A1 (es) | 2003-08-29 |
| US20030232018A1 (en) | 2003-12-18 |
| EP1465664A1 (en) | 2004-10-13 |
| PL371261A1 (en) | 2005-06-13 |
| WO2003061708A1 (en) | 2003-07-31 |
| JP2005515245A (ja) | 2005-05-26 |
| KR20040077878A (ko) | 2004-09-07 |
| TW200307750A (en) | 2003-12-16 |
| IL162404A0 (en) | 2005-11-20 |
| PE20030851A1 (es) | 2004-01-01 |
| CA2469721A1 (en) | 2003-07-31 |
| BR0306925A (pt) | 2004-11-09 |
| MXPA04006995A (es) | 2005-07-13 |
| RU2004125283A (ru) | 2005-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |