ATE341614T1 - Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten - Google Patents

Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten

Info

Publication number
ATE341614T1
ATE341614T1 AT99906690T AT99906690T ATE341614T1 AT E341614 T1 ATE341614 T1 AT E341614T1 AT 99906690 T AT99906690 T AT 99906690T AT 99906690 T AT99906690 T AT 99906690T AT E341614 T1 ATE341614 T1 AT E341614T1
Authority
AT
Austria
Prior art keywords
virus
concentration
methods
containing compositions
preparations
Prior art date
Application number
AT99906690T
Other languages
English (en)
Inventor
Andreas Frei
Henry K H Kwan
Varda E Sandweiss
Gary J Vellekamp
Pui-Ho Yuen
Laureano L Bondoc Jr
Frederick William Porter Iv
John Chu-Tay Tang
Peter Ihnat
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE341614T1 publication Critical patent/ATE341614T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
AT99906690T 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten ATE341614T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2446298A 1998-02-17 1998-02-17
US7964398A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
ATE341614T1 true ATE341614T1 (de) 2006-10-15

Family

ID=26698472

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99906690T ATE341614T1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
AT04030395T ATE371020T1 (de) 1998-02-17 1999-02-12 Virusenthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
AT06019642T ATE478945T1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT04030395T ATE371020T1 (de) 1998-02-17 1999-02-12 Virusenthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
AT06019642T ATE478945T1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten

Country Status (25)

Country Link
EP (4) EP1526173B1 (de)
JP (3) JP4358434B2 (de)
KR (5) KR100918187B1 (de)
CN (2) CN101164623B (de)
AR (3) AR020054A1 (de)
AT (3) ATE341614T1 (de)
AU (1) AU757976B2 (de)
BR (1) BR9908015A (de)
CA (2) CA2320419C (de)
CO (1) CO4820440A1 (de)
DE (3) DE69933433T2 (de)
DK (1) DK1054955T3 (de)
ES (2) ES2290613T3 (de)
HK (3) HK1073481A1 (de)
HU (1) HU226015B1 (de)
ID (1) ID28298A (de)
IL (2) IL137510A0 (de)
MY (1) MY141641A (de)
NO (1) NO20004104L (de)
PE (1) PE20000265A1 (de)
PL (1) PL197747B1 (de)
PT (1) PT1054955E (de)
SK (1) SK11842000A3 (de)
TW (1) TWI232107B (de)
WO (1) WO1999041416A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
JP4492826B2 (ja) 1996-11-20 2010-06-30 イントロジェン セラピューティクス，インコーポレイテッド アデノウイルスベクターの産生および精製のための改良された方法
EP1133316B1 (de) * 1998-11-16 2009-01-21 Introgen Therapeutics, Inc. Adenovirus-formulierungen zur gentherapie
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
EP1263461A4 (de) * 2000-03-07 2009-08-12 Merck & Co Inc Adenovirus-formulierungen
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
US20020064860A1 (en) 2000-11-29 2002-05-30 Schering Corporation Method for purifying adenoviruses
AU2002218535A1 (en) * 2000-12-12 2002-06-24 Japan Tobacco Inc. Pharmaceutical composition containing an active with a hemolytic action and a surfactant
CA2469491A1 (en) 2001-12-12 2003-06-19 Kerrie Setiawan Composition for viral preservation
US20030153065A1 (en) * 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
MXPA04006995A (es) * 2002-01-18 2005-07-13 Schering Ag Formulaciones estabilizadas de adenovirus.
ATE435906T1 (de) 2004-02-23 2009-07-15 Crucell Holland Bv Verfahren zur reinigung von viren
CA2586107A1 (en) 2004-11-03 2006-05-18 Introgen Therapeutics Inc. A novel method for the production and purification of adenoviral vectors
EP1831352B1 (de) 2004-12-13 2011-07-13 CANJI, Inc. Zellinien zur produktion von replikationsdefektem adenovirus
DK1869171T4 (en) 2005-04-11 2016-01-18 Crucell Holland Bv Virus cleaning using ultrafiltration
CN1961961B (zh) * 2005-11-11 2010-05-26 深圳市源兴生物医药科技有限公司 一种药物制剂及其制备方法
WO2007070392A2 (en) 2005-12-12 2007-06-21 Canji, Inc. Adenoviral expression vectors having an expression cassette in the e1 region and an inactivated e2b polymerase
WO2007123961A2 (en) * 2006-04-20 2007-11-01 Wyeth Purification processes for isolating purified vesicular stomatitis virus from cell culture
US10041049B2 (en) 2008-11-03 2018-08-07 Janssen Vaccines & Prevention B.V. Method for the production of adenoviral vectors
MX356669B (es) 2009-05-02 2018-06-08 Genzyme Corp Terapia genica para trastornos neurodegenerativos.
CA2786835C (en) 2010-02-15 2021-08-31 Crucell Holland B.V. Method for the production of ad26 adenoviral vectors
WO2012038367A1 (en) 2010-09-20 2012-03-29 Crucell Holland B.V. Therapeutic vaccination against active tuberculosis
WO2012041669A1 (en) 2010-09-27 2012-04-05 Crucell Holland B.V. Heterologous prime boost vaccination regimen against malaria
US9045728B2 (en) * 2010-12-02 2015-06-02 Oncolytics Biotech Inc. Liquid viral formulations
TW201233803A (en) 2010-12-02 2012-08-16 Oncolytics Biotech Inc Lyophilized viral formulations
SG194449A1 (en) * 2011-04-29 2013-12-30 Oncolytics Biotech Inc Methods of purifying viruses using gel permeation chromatography
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
KR102044051B1 (ko) 2012-03-12 2019-11-12 얀센 백신스 앤드 프리벤션 비.브이. 터미널 말단이 변경된 재조합 아데노바이러스의 배치
US9125870B2 (en) 2012-03-22 2015-09-08 Crucell Holland B.V. Vaccine against RSV
WO2013139916A1 (en) 2012-03-22 2013-09-26 Crucell Holland B.V. Vaccine against rsv
DK2988780T3 (en) 2013-04-25 2019-04-08 Janssen Vaccines & Prevention Bv STABILIZED SOLVEN RSV-F PREFUSION POLYPTIDES
US10294279B2 (en) 2013-06-17 2019-05-21 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F polypeptides
KR20170004966A (ko) * 2014-05-28 2017-01-11 에이전시 포 사이언스, 테크놀로지 앤드 리서치 바이러스 감소 방법
PL3283634T3 (pl) 2015-04-14 2019-10-31 Janssen Vaccines & Prevention Bv Rekombinowany adenowirus eksprymujący dwa transgeny z dwukierunkowym promotorem
BR112017027448A2 (pt) 2015-07-07 2018-09-04 Janssen Vaccines & Prevention Bv vacina contra rsv
BR112017028449A2 (pt) 2015-07-07 2018-09-04 Janssen Vaccines & Prevention Bv polipeptídeos rsv f pré-fusão solúveis estabilizados
CA3018139A1 (en) 2016-04-05 2017-10-12 Janssen Vaccines & Prevention B.V. Vaccine against rsv
SG11201807913XA (en) 2016-04-05 2018-10-30 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f proteins
SG11201810078PA (en) 2016-05-30 2018-12-28 Janssen Vaccines & Prevention Bv Stabilized pre-fusion rsv f proteins
EP3472327B1 (de) 2016-06-20 2020-08-19 Janssen Vaccines & Prevention B.V. Potenter und ausbalancierter bidirektionaler promotor
US10744196B2 (en) 2016-07-14 2020-08-18 Janssen Vaccines & Prevention B.V. HPV vaccines
WO2018210871A1 (en) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
US11229692B2 (en) 2017-05-17 2022-01-25 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
WO2019021305A1 (en) * 2017-07-24 2019-01-31 Ella Foundation VACCINE AGAINST FOOT AND MOUTH DISEASE
EP3681533A1 (de) 2017-09-15 2020-07-22 Janssen Vaccines & Prevention B.V. Verfahren zur sicheren induktion der immunität gegen rsv
EP3990031A4 (de) * 2019-06-28 2023-08-09 Takeda Pharmaceutical Company Limited Verfahren zur reinigung adeno-assoziierter viren
JP2023512519A (ja) 2020-01-31 2023-03-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド コロナウイルス感染症を予防および処置するための組成物および方法－ｓａｒｓ－ｃｏｖ－２ワクチン
JP2024509756A (ja) 2021-02-19 2024-03-05 ヤンセン ファッシンズ アンド プリベンション ベーフェー 安定化された融合前ｒｓｖ ｆｂ抗原
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
CN115989321A (zh) * 2021-08-17 2023-04-18 上海行深生物科技有限公司 病毒制剂、用于配制病毒制剂的溶液及其用途
WO2023111725A1 (en) 2021-12-14 2023-06-22 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE299213C (de) *
US4147772A (en) * 1976-02-03 1979-04-03 Merck & Co., Inc. Vaccine stabilizer
GB1575155A (en) * 1978-04-11 1980-09-17 Merck & Co Inc Vaccine stabilizer
BE866330A (fr) * 1978-04-25 1978-10-25 Merck & Co Inc Procede de fabrication d'un agent de stabilisation de vaccin
US5532220A (en) 1987-08-31 1996-07-02 The Regents Of The University Of California Genetic mechanisms of tumor suppression
DD299213A7 (de) * 1988-05-04 1992-04-09 Saechsische Landesgewerbefoerderungsgesellschaft M.B.H.,De Verfahren zur stabilisierung eines lebendvirusimpfstoffes gegen temperatureinwirkung
DD295927A5 (de) * 1988-05-06 1991-11-14 Saechsisches Serumwerk Gmbh Dresden, Immobilisiertes immunologisch aktives reagens
EP2113569A1 (de) 1993-10-25 2009-11-04 CANJI, Inc. Rekombinanter Adenovirusvektor und Anwendungsverfahren
KR100368686B1 (ko) * 1994-12-29 2003-12-01 주식회사 엘지생명과학 수크로즈를이용한세포와바이러스의분리방법
FR2742756B1 (fr) * 1995-12-22 1998-04-03 Pasteur Merieux Serums Vacc Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation
US5789244A (en) * 1996-01-08 1998-08-04 Canji, Inc. Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems

Also Published As

Publication number Publication date
AR063314A2 (es) 2009-01-21
ES2272053T3 (es) 2007-04-16
EP1526173A2 (de) 2005-04-27
WO1999041416A2 (en) 1999-08-19
KR20090127947A (ko) 2009-12-14
PL342847A1 (en) 2001-07-16
AR020054A1 (es) 2002-04-10
SK11842000A3 (sk) 2001-05-10
HK1073481A1 (en) 2005-10-07
AU2653899A (en) 1999-08-30
CA2320419C (en) 2011-02-08
PE20000265A1 (es) 2000-04-25
DE69933433D1 (de) 2006-11-16
KR100862169B1 (ko) 2008-10-09
DE69936948D1 (de) 2007-10-04
JP2010213727A (ja) 2010-09-30
HK1028416A1 (en) 2001-02-16
JP2006166925A (ja) 2006-06-29
AU757976B2 (en) 2003-03-13
EP1054955B1 (de) 2006-10-04
CO4820440A1 (es) 1999-07-28
EP1054955A2 (de) 2000-11-29
EP1741777A1 (de) 2007-01-10
KR20090038927A (ko) 2009-04-21
KR20080065615A (ko) 2008-07-14
KR100912362B1 (ko) 2009-08-19
EP1526173A3 (de) 2005-08-10
CA2723040A1 (en) 1999-08-19
DE69942708D1 (de) 2010-10-07
IL137510A (en) 2012-10-31
ATE371020T1 (de) 2007-09-15
EP1526174A3 (de) 2005-08-31
CN100374551C (zh) 2008-03-12
HK1097413A1 (en) 2007-06-22
CN101164623A (zh) 2008-04-23
IL137510A0 (en) 2001-07-24
WO1999041416A3 (en) 1999-11-18
NO20004104L (no) 2000-10-17
DE69936948T2 (de) 2008-05-15
KR20080065614A (ko) 2008-07-14
TWI232107B (en) 2005-05-11
DE69933433T2 (de) 2007-08-23
CA2320419A1 (en) 1999-08-19
KR100918187B1 (ko) 2009-09-22
HUP0100670A3 (en) 2003-10-28
CN1297478A (zh) 2001-05-30
ES2290613T3 (es) 2008-02-16
EP1526174B1 (de) 2007-08-22
ID28298A (id) 2001-05-10
KR100991683B1 (ko) 2010-11-04
PT1054955E (pt) 2007-01-31
ATE478945T1 (de) 2010-09-15
KR101018992B1 (ko) 2011-03-07
JP2002503484A (ja) 2002-02-05
HU226015B1 (en) 2008-02-28
MY141641A (en) 2010-05-31
EP1741777B1 (de) 2010-08-25
KR20010072547A (ko) 2001-07-31
CN101164623B (zh) 2012-11-14
EP1526173B1 (de) 2012-11-21
NO20004104D0 (no) 2000-08-16
DK1054955T3 (da) 2007-01-15
HUP0100670A2 (hu) 2001-06-28
JP4358434B2 (ja) 2009-11-04
PL197747B1 (pl) 2008-04-30
EP1526174A2 (de) 2005-04-27
BR9908015A (pt) 2001-04-24
AR063315A2 (es) 2009-01-21

Similar Documents

Publication Publication Date Title
ATE341614T1 (de) Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
ATE363904T1 (de) Benzimidazol-2-carbamat zur behandlung viraler infektionen und von krebs
DE69837703D1 (de) Methoden zum nachweis und zur analyse von virus
ATE477270T1 (de) Verfahren und zusammensetzungen zur prävention und behandlung von anämie
DE19882430T1 (de) Korrektur von Emissions-Kontamination und Totzeitverlust
DE60227095D1 (de) Zusammensetzungen und verfahren zur behandlung von abgebundenem gips
DE69921853D1 (de) Vorrichtung zur behandlung von abgas
ATE478138T1 (de) Verfahren zur inaktivierung von lipidumhüllten viren
DE60035497D1 (de) Verfharen zur konservierung von viren und mycoplasma
DE69822473D1 (de) Lipid-polyamid-konjugate und zusammensetzungen zur verabreichung von nucleinsäuremolekülen
DE69932845D1 (de) Methoden zur quantifizierung von hla-dr und cd11b
DE29801590U1 (de) Blutbeutelsystem zur Virusinaktivierung von Blut, Blutkomponenten und Plasma
DE69935326D1 (de) Zusammensetzungen enthaltend molybden zur steigerung des proteinanabolismus und der entgiftung
DE69933121D1 (de) Methode, reagent und testsatz zur typisierung des genoms von papillomavirus
DE60222233D1 (de) Prozessor und Verfahren zur Erhaltung der Verarbeitungsreihenfolge von Paketen basierend auf Paketstromkennungen
DE69631443D1 (de) Reagens zur untersuchung von viren-agglutination und kit zur untersuchung auf viren
DE60031826D1 (de) Trennung von Viren und Nachweis von Viren
ATE211928T1 (de) Verfahren zur inaktivierung von viren in proteinen
DE60200713D1 (de) Zusammensetzung enthaltend getrocknetes Vollei zur Behandlung von Hepatitis
DE59905059D1 (de) Verfahren zur Herstellung von Hydroxyethylcyclohexanen und Hydroxyethylpiperidinen
DE69830156D1 (de) Zusammensetzungen zur immunverstärkung von impfstoffen
ATA4812000A (de) Mittel zur behandlung von hepatitis c
DE69428610D1 (de) Methoden zur kultivierung von infektiösem laryngotracheitis virus und von "egg-drop-syndrome" verursachendem virus
DE59813114D1 (de) BK-RiV-Präparate zur Behandlung von proliferativen Zellerkrangungen
DE60008697D1 (de) Verfahren zur Herstellung von 4-(P-methoxyphenyl)-2-amino-butane und Insektizide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1054955

Country of ref document: EP

REN Ceased due to non-payment of the annual fee