CN100368398C - 3-氮杂二环(3.1.0)己烷衍生物作为类阿片受体拮抗剂 - Google Patents

3-氮杂二环(3.1.0)己烷衍生物作为类阿片受体拮抗剂 Download PDF

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Publication number
CN100368398C
CN100368398C CNB028208854A CN02820885A CN100368398C CN 100368398 C CN100368398 C CN 100368398C CN B028208854 A CNB028208854 A CN B028208854A CN 02820885 A CN02820885 A CN 02820885A CN 100368398 C CN100368398 C CN 100368398C
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aza
bicyclo
hex
ethyl
phenyl
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CN1610664A (zh
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S·F·麦克哈迪
S·利拉斯
S·D·赫克
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Pfizer Products Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P37/08—Antiallergic agents
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB028208854A 2001-10-22 2002-09-09 3-氮杂二环(3.1.0)己烷衍生物作为类阿片受体拮抗剂 Expired - Fee Related CN100368398C (zh)

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US33851101P 2001-10-22 2001-10-22
US60/338,511 2001-10-22

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CN1610664A CN1610664A (zh) 2005-04-27
CN100368398C true CN100368398C (zh) 2008-02-13

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EP (1) EP1440059B1 (https=)
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CN107428687A (zh) * 2015-05-20 2017-12-01 株式会社三和化学研究所 一种新型的3‑氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用

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RU2006112576A (ru) * 2003-10-16 2006-08-27 Пфайзер Продактс Инк. (Us) Получение производных 3-азабицикло [3.1.0] гексана
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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
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TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
US7691878B2 (en) * 2007-08-27 2010-04-06 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029252A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
US9663463B2 (en) * 2013-11-20 2017-05-30 Sanwa Kagaku Kenkyusho Co., Ltd. 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose
CN110352055A (zh) 2017-03-02 2019-10-18 株式会社三和化学研究所 酒精使用障碍的治疗药物

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428687A (zh) * 2015-05-20 2017-12-01 株式会社三和化学研究所 一种新型的3‑氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CN107428687B (zh) * 2015-05-20 2021-06-11 宇部兴产株式会社 一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用

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BR0213464A (pt) 2004-11-09
CN1610664A (zh) 2005-04-27
IL161157A (en) 2009-09-01
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ES2302839T3 (es) 2008-08-01
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US20050171178A1 (en) 2005-08-04
SI1440059T1 (sl) 2008-08-31
NZ531807A (en) 2006-03-31
JP2005511545A (ja) 2005-04-28
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US7049335B2 (en) 2006-05-23
NO329092B1 (no) 2010-08-23
SV2004001363A (es) 2004-02-24
KR20040048984A (ko) 2004-06-10
MA27141A1 (fr) 2005-01-03
PY0225353A (es) 2004-05-03
TNSN04071A1 (fr) 2006-06-01
EP1440059A1 (en) 2004-07-28
GEP20084300B (en) 2008-02-11
HRP20040288A2 (en) 2004-12-31
HK1072052A1 (zh) 2005-08-12
IL161157A0 (en) 2004-08-31
OA12711A (en) 2006-06-27
AP1816A (en) 2008-01-04
PL368919A1 (en) 2005-04-04
EA006708B1 (ru) 2006-02-24
JP4155522B2 (ja) 2008-09-24
KR100621292B1 (ko) 2006-09-13
HUP0401884A2 (hu) 2005-01-28
MXPA04003730A (es) 2004-07-23
US20070054950A1 (en) 2007-03-08
WO2003035622A1 (en) 2003-05-01
UA75714C2 (en) 2006-05-15
PA8556701A1 (es) 2003-07-28
AP2004003007A0 (en) 2004-06-30
MY136580A (en) 2008-10-31
AU2002329557B2 (en) 2008-07-31
EP1440059B1 (en) 2008-04-16
JP2008069169A (ja) 2008-03-27
ATE392415T1 (de) 2008-05-15
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
PE20030610A1 (es) 2003-07-12
RS25104A (sr) 2007-02-05
ZA200402172B (en) 2006-09-27
DK1440059T3 (da) 2008-07-14

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