CN100356978C - 新型exendin激动剂制剂及其给药方法 - Google Patents

新型exendin激动剂制剂及其给药方法 Download PDF

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Publication number
CN100356978C
CN100356978C CNB008048479A CN00804847A CN100356978C CN 100356978 C CN100356978 C CN 100356978C CN B008048479 A CNB008048479 A CN B008048479A CN 00804847 A CN00804847 A CN 00804847A CN 100356978 C CN100356978 C CN 100356978C
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China
Prior art keywords
solvent
peptide
exendin
xaa
tfa
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Expired - Lifetime
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CNB008048479A
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English (en)
Chinese (zh)
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CN1384755A (zh
Inventor
A·杨
J·J·利塔利恩
O·科特曼
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Amylin Pharmaceuticals LLC
AstraZeneca Pharmaceuticals LP
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Amylin Pharmaceuticals LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
CNB008048479A 1999-01-14 2000-01-14 新型exendin激动剂制剂及其给药方法 Expired - Lifetime CN100356978C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11638099P 1999-01-14 1999-01-14
US60/116380 1999-01-14
US17536500P 2000-01-10 2000-01-10
US60/175365 2000-01-10

Related Child Applications (1)

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CNA2007101658564A Division CN101181236A (zh) 1999-01-14 2000-01-14 新型exendin激动剂制剂及其给药方法

Publications (2)

Publication Number Publication Date
CN1384755A CN1384755A (zh) 2002-12-11
CN100356978C true CN100356978C (zh) 2007-12-26

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ID=26814176

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CNB008048479A Expired - Lifetime CN100356978C (zh) 1999-01-14 2000-01-14 新型exendin激动剂制剂及其给药方法
CNA2007101658564A Pending CN101181236A (zh) 1999-01-14 2000-01-14 新型exendin激动剂制剂及其给药方法

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US (1) US6902744B1 (https=)
EP (2) EP1140145B2 (https=)
JP (1) JP4426727B2 (https=)
KR (1) KR100675711B1 (https=)
CN (2) CN100356978C (https=)
AT (1) ATE299031T2 (https=)
AU (2) AU777564B2 (https=)
BR (1) BRPI0007820B8 (https=)
CA (1) CA2356706C (https=)
CY (1) CY2007013I2 (https=)
DE (3) DE122007000001I1 (https=)
DK (1) DK1140145T4 (https=)
ES (1) ES2244416T5 (https=)
HK (1) HK1040635B (https=)
LU (1) LU91343I2 (https=)
NL (1) NL300282I1 (https=)
NO (2) NO331382B1 (https=)
NZ (1) NZ512663A (https=)
PT (1) PT1140145E (https=)
RU (1) RU2242244C2 (https=)
WO (1) WO2000041546A2 (https=)

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