CN102100912B - 一种给药组合物及其制备和使用方法 - Google Patents
一种给药组合物及其制备和使用方法 Download PDFInfo
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- CN102100912B CN102100912B CN200910201248.3A CN200910201248A CN102100912B CN 102100912 B CN102100912 B CN 102100912B CN 200910201248 A CN200910201248 A CN 200910201248A CN 102100912 B CN102100912 B CN 102100912B
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
- 229960004276 zoledronic acid Drugs 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
Abstract
Description
时间(分钟) | 艾赛那肽释放(%) | 葵酸钠释放(%) |
0 | 0 | 0 |
15 | 0 | 0 |
30 | 0 | 0 |
60 | 21.73 | 23.54 |
90 | 66.91 | 60.48 |
120 | 90.15 | 91.55 |
180 | 92.82 | 92.36 |
240 | 92.85 | 87.72 |
时间(分 钟) | 艾塞那肽释放(%) | 癸酸钠释放(%) |
0 | 0 | 0 |
15 | 0 | 0 |
30 | 0 | 0 |
60 | 6.05 | 7.3 |
90 | 11.41 | 19.75 |
120 | 27.91 | 44.4 |
180 | 66.99 | 85.07 |
240 | 74.01 | 91.34 |
时间(分钟) | 艾塞那肽释放(%) | 癸酸钠释放(%) |
0 | 0 | 0 |
15 | 0 | 0 |
30 | 0 | 0 |
60 | 0 | 0 |
90 | 11.43 | 7.96 |
120 | 25.65 | 20.78 |
180 | 37.63 | 40.05 |
240 | 49.75 | 51.29 |
300 | 76.22 | 87.28 |
360 | 79.85 | 87.58 |
540 | 79.64 | 91.7 |
编号 | 组别 | 给药情况 |
1 | 空白组 | 安慰片 |
2 | 皮下注射组 | 皮下注射60μg/10mM醋酸钠溶液,pH 4.0 |
3 | 无粘附层组 | 3mg艾塞那肽、100mg癸酸钠,肠溶包衣 |
4 | HPMC包衣组 | 3mg艾塞那肽、100mg癸酸钠,HPMC及肠溶包衣 |
5 | AA1包衣组 | 3mg艾塞那肽、100mg癸酸钠,AA1及肠溶包衣 |
6 | 壳聚糖包衣组 | 3mg艾塞那肽、100mg癸酸钠,壳聚糖及肠溶包衣 |
组别 | 动物数 | 生物利用率(%) |
空白 | 3 | 0 |
皮下注射 | 3 | 100 |
无黏附层 | 3 | 0.19 |
HPMC包衣 | 3 | 2.12 |
AA1包衣 | 3 | 2.37 |
壳聚糖包衣 | 3 | 1.25 |
编号 | 组别 | 给药情况 |
1 | 空白组 | 安慰片 |
2 | 皮下注射组 | 皮下注射60μg/10mM醋酸钠溶液,pH 4.0 |
3 | 无黏附层组 | 5mg艾塞那肽,500mg癸酸钠,肠溶包衣 |
4 | AA1包衣组 | 3mg艾塞那肽,400mg癸酸钠,AA1及肠溶包衣 |
组别 | 动物数 | 生物利用率(%) |
空白组 | 3 | 0 |
皮下注射 | 3 | 100 |
无黏附层 | 3 | 0.61 |
AA1包衣组 | 3 | 2.34 |
编号 | 组别 | 给药情况 |
1 | 空白组 | 安慰片 |
2 | 皮下注射组 | 皮下注射60μg/10mM醋酸钠溶液,pH 4.0 |
3 | 50mg组 | 3mg艾塞那肽,50mg癸酸钠,HPMC及肠溶包衣 |
4 | 100mg组 | 3mg艾塞那肽,100mg癸酸钠,HPMC及肠溶包衣 |
5 | 200mg组 | 3mg艾塞那肽,200mg癸酸钠,HPMC及肠溶包衣 |
6 | 400mg组 | 3mg艾塞那肽,400mg癸酸钠,HPMC及肠溶包衣 |
组别 | 动物数 | 生物利用率(%) |
空白组 | 3 | 0 |
皮下注射组 | 3 | 100 |
50mg组 | 3 | 0.08 |
100mg组 | 3 | 2.37 |
200mg组 | 3 | 2.62 |
400mg组 | 3 | 2.34 |
编号 | 组别 | 给药情况 |
1 | 空白组 | 安慰片 |
2 | 皮下注射 | 皮下注射60μg/10mM醋酸钠溶液,pH 4.0 |
3 | 无单向包衣 | 3mg艾塞那肽,50mg癸酸钠,HPMC及肠溶包衣 |
4 | CA包衣 | 3mg艾塞那肽,50mg癸酸钠,HPMC及肠溶包衣后再用 醋酸纤维素包衣 |
5 | EC包衣 | 3mg艾塞那肽,50mg癸酸钠,HPMC及肠溶包衣后再用 乙基纤维素包衣 |
组别 | 动物数 | 生物利用率(%) |
空白组 | 3 | 0 |
皮下注射组 | 3 | 100 |
无单向包衣组 | 3 | 0.08 |
CA包衣组 | 3 | 0.34 |
EC包衣组 | 3 | 0.78 |
编号 | 组别 | 给药情况 |
1 | 空白组 | 安慰片 |
2 | 皮下注射 | 皮下注射60μg/10mM醋酸钠溶液,pH4.0 |
3 | EC包衣 | 1mg艾塞那肽,100mg癸酸钠,HPMC及肠溶包衣后再 用乙基纤维素包衣 |
组别 | 动物数 | 生物利用率(%) |
空白组 | 3 | 0 |
皮下注射组 | 3 | 100 |
EC包衣组 | 3 | 4.98 |
Claims (14)
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CN200910201248.3A CN102100912B (zh) | 2009-12-16 | 2009-12-16 | 一种给药组合物及其制备和使用方法 |
PCT/US2010/060809 WO2011084618A2 (en) | 2009-12-16 | 2010-12-16 | Compositions and methods for oral drug delivery |
CA2784120A CA2784120A1 (en) | 2009-12-16 | 2010-12-16 | Compositions and methods for oral drug delivery |
AU2010339907A AU2010339907A1 (en) | 2009-12-16 | 2010-12-16 | Compositions and methods for oral drug delivery |
EP10795591A EP2512454A2 (en) | 2009-12-16 | 2010-12-16 | Compositions and methods for oral drug delivery |
US12/970,637 US20110142889A1 (en) | 2009-12-16 | 2010-12-16 | Compositions and methods for oral drug delivery |
JP2012544835A JP2013514976A (ja) | 2009-12-16 | 2010-12-16 | 経口薬物送達のための組成物および方法 |
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CN102335431B (zh) * | 2010-07-14 | 2015-08-26 | 上海蓝心医药科技有限公司 | 一种给药组合物及其制备和使用方法 |
CN103520706B (zh) * | 2013-10-09 | 2019-02-26 | 天津林达生物科技有限公司 | 口服用重组人血清白蛋白融合蛋白制剂配方、产品及用途 |
KR101768446B1 (ko) * | 2014-03-21 | 2017-08-17 | 애니젠 주식회사 | 신규한 엑세나타이드 유사체 및 그의 용도 |
CN112057619A (zh) * | 2019-06-10 | 2020-12-11 | 苏州兰鼎生物制药有限公司 | 一种具有降血糖作用的药物组合物 |
CN111700867B (zh) * | 2020-05-18 | 2023-03-28 | 四川省人民医院 | 一种去氢骆驼蓬碱胃肠道黏附片及其制备方法 |
CN113317506A (zh) * | 2021-06-08 | 2021-08-31 | 广西壮族自治区农业科学院 | 一种降尿酸固体饮料及其制备方法 |
CN113303472A (zh) * | 2021-06-08 | 2021-08-27 | 广西壮族自治区农业科学院 | 一种利用赤苍藤生产的功能饮料及其制备工艺 |
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CN1384755A (zh) * | 1999-01-14 | 2002-12-11 | 安米林药品公司 | 新型exendin激动剂制剂及其给药方法 |
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CN101095942A (zh) * | 2006-06-30 | 2008-01-02 | 北京民海生物科技有限公司 | 一种包含稳定剂的Exendin注射剂药物配方 |
CN101444618A (zh) * | 2007-11-26 | 2009-06-03 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
CN101601646A (zh) * | 2009-07-22 | 2009-12-16 | 南京凯瑞尔纳米生物技术有限公司 | 治疗糖尿病的鼻腔滴剂及其制备方法 |
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US7115569B2 (en) * | 1997-01-07 | 2006-10-03 | Amylin Pharmaceuticals, Inc. | Exendins, exendin agonists, and methods for their use |
CN1384755A (zh) * | 1999-01-14 | 2002-12-11 | 安米林药品公司 | 新型exendin激动剂制剂及其给药方法 |
CN101095942A (zh) * | 2006-06-30 | 2008-01-02 | 北京民海生物科技有限公司 | 一种包含稳定剂的Exendin注射剂药物配方 |
CN101444618A (zh) * | 2007-11-26 | 2009-06-03 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
CN101601646A (zh) * | 2009-07-22 | 2009-12-16 | 南京凯瑞尔纳米生物技术有限公司 | 治疗糖尿病的鼻腔滴剂及其制备方法 |
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