CL2023002013A1 - Compuestos de isoindolinona - Google Patents

Compuestos de isoindolinona

Info

Publication number
CL2023002013A1
CL2023002013A1 CL2023002013A CL2023002013A CL2023002013A1 CL 2023002013 A1 CL2023002013 A1 CL 2023002013A1 CL 2023002013 A CL2023002013 A CL 2023002013A CL 2023002013 A CL2023002013 A CL 2023002013A CL 2023002013 A1 CL2023002013 A1 CL 2023002013A1
Authority
CL
Chile
Prior art keywords
isoindolinone compounds
compounds
stereoisomers
mammals
compound
Prior art date
Application number
CL2023002013A
Other languages
English (en)
Spanish (es)
Inventor
Fasching Bernhard
Ryckmans Thomas
Flohr Alexander
Ritzén Andreas
HARVEY Freya
MCALLISTER Laura
Original Assignee
Monte Rosa Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monte Rosa Therapeutics Inc filed Critical Monte Rosa Therapeutics Inc
Publication of CL2023002013A1 publication Critical patent/CL2023002013A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2023002013A 2021-01-13 2023-07-11 Compuestos de isoindolinona CL2023002013A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH252021 2021-01-13
CH3862021 2021-04-14
CH6552021 2021-06-04
US202163281049P 2021-11-18 2021-11-18

Publications (1)

Publication Number Publication Date
CL2023002013A1 true CL2023002013A1 (es) 2024-01-05

Family

ID=79730447

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002013A CL2023002013A1 (es) 2021-01-13 2023-07-11 Compuestos de isoindolinona

Country Status (9)

Country Link
US (2) US11912682B2 (https=)
EP (1) EP4277901A1 (https=)
JP (1) JP2024504932A (https=)
AU (1) AU2022207648A1 (https=)
CA (1) CA3208313A1 (https=)
CL (1) CL2023002013A1 (https=)
IL (1) IL304325A (https=)
MX (1) MX2023008296A (https=)
WO (1) WO2022152821A1 (https=)

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WO2024015855A1 (en) * 2022-07-13 2024-01-18 Monte Rosa Therapeutics, Inc. COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS
EP4554935A1 (en) * 2022-07-14 2025-05-21 Monte Rosa Therapeutics AG Methods of preparing an isoindolinone derivative and crystal forms thereof
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WO2024125437A1 (zh) * 2022-12-13 2024-06-20 南京圣和药业股份有限公司 Gspt1降解剂及其应用
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TW202440574A (zh) 2023-02-09 2024-10-16 印度商薩蒂亞製藥創新私人有限公司 作為ｐｋｍｙｔ１抑制劑的雜芳基化合物
WO2025016457A1 (zh) * 2023-07-19 2025-01-23 杭州德睿智药科技有限公司 作为GSPTs/MYC信号通量调节的新型取代杂环类化合物
CN121532386A (zh) * 2023-07-28 2026-02-13 杭州中美华东制药有限公司 具有蛋白降解作用的芳胺类化合物
CN121311477A (zh) * 2023-09-06 2026-01-09 上海超阳药业有限公司 内酰胺类衍生物及其应用
CN121219280A (zh) * 2023-09-26 2025-12-26 映恩生物制药（苏州）有限公司 哌啶二酮类化合物、其制备方法和用途
CN117304050A (zh) * 2023-10-10 2023-12-29 韶远科技（上海)有限公司 一种n-(3-溴-5-氟-4-甲基苯基)乙酰胺的制备方法
WO2025078667A1 (en) 2023-10-13 2025-04-17 Monte Rosa Therapeutics Ag Gspt1 molecular glue degrader mrt-2359 for use in the treatment of a myc-driven cancer
WO2025121362A1 (ja) * 2023-12-05 2025-06-12 株式会社フジモト・コーポレーション ジオキソピペリジン誘導体およびその用途
WO2025172576A1 (en) 2024-02-15 2025-08-21 Monte Rosa Therapeutics Ag Methods of treatment of cancer with gspt1 degraders
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