CL2014002511A1 - Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras. - Google Patents

Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras.

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Publication number
CL2014002511A1
CL2014002511A1 CL2014002511A CL2014002511A CL2014002511A1 CL 2014002511 A1 CL2014002511 A1 CL 2014002511A1 CL 2014002511 A CL2014002511 A CL 2014002511A CL 2014002511 A CL2014002511 A CL 2014002511A CL 2014002511 A1 CL2014002511 A1 CL 2014002511A1
Authority
CL
Chile
Prior art keywords
wnt signaling
indazole
imidazo
osteoarthritis
pyridin
Prior art date
Application number
CL2014002511A
Other languages
English (en)
Spanish (es)
Inventor
John Hood
David Mark Wallace
Sunil Kumar Kc
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49292798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002511(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of CL2014002511A1 publication Critical patent/CL2014002511A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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CL2014002511A 2012-04-04 2014-09-23 Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras. CL2014002511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261620107P 2012-04-04 2012-04-04

Publications (1)

Publication Number Publication Date
CL2014002511A1 true CL2014002511A1 (es) 2015-01-09

Family

ID=49292798

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002511A CL2014002511A1 (es) 2012-04-04 2014-09-23 Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras.

Country Status (33)

Country Link
US (9) US8673936B2 (enExample)
EP (3) EP3284744B1 (enExample)
JP (3) JP6167169B2 (enExample)
KR (1) KR102048107B1 (enExample)
CN (2) CN104202984B (enExample)
AU (2) AU2013243899B2 (enExample)
BR (1) BR112014023639B1 (enExample)
CA (1) CA2853703C (enExample)
CL (1) CL2014002511A1 (enExample)
CO (1) CO7230336A2 (enExample)
CY (1) CY1119485T1 (enExample)
DK (1) DK2760285T3 (enExample)
ES (1) ES2635386T3 (enExample)
HR (1) HRP20171322T1 (enExample)
HU (1) HUE033829T2 (enExample)
IL (2) IL234743A (enExample)
LT (1) LT2760285T (enExample)
MA (1) MA37450B1 (enExample)
ME (1) ME02832B (enExample)
MX (1) MX355435B (enExample)
MY (1) MY174896A (enExample)
NZ (3) NZ727358A (enExample)
PE (1) PE20142216A1 (enExample)
PH (3) PH12017500997A1 (enExample)
PL (1) PL2760285T3 (enExample)
PT (1) PT2760285T (enExample)
RS (1) RS56292B1 (enExample)
RU (2) RU2638932C2 (enExample)
SG (2) SG10201610539RA (enExample)
SI (1) SI2760285T1 (enExample)
SM (1) SMT201700414T1 (enExample)
WO (1) WO2013151708A1 (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10259817B2 (en) 2015-06-23 2019-04-16 Eisai R&D Management Co., Ltd. Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
US12226409B2 (en) 2017-05-16 2025-02-18 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition

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BR112012002854B1 (pt) 2009-08-10 2020-02-18 Samumed, Llc Composto ou sal farmaceuticamente aceitável, composição farmacêutica e uso dos mesmos
ES2652287T3 (es) 2009-12-21 2018-02-01 Samumed, Llc 1H-pirazol [3,4-b] piridinas y usos terapéuticos de las mismas
ME03332B (me) 2011-09-14 2019-10-20 Samumed Llc Indazol-3-karboksamidi i njihova upotreba kao inhibitora signalnog puta wnt/b-katenina
PH12017500997A1 (en) * 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
HUE046216T2 (hu) 2012-05-04 2020-02-28 Samumed Llc 1H-pirazolo [3,4-b]piridin-származékok és terápiás alkalmazásuk
WO2014110086A2 (en) 2013-01-08 2014-07-17 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
GB201322334D0 (en) * 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
WO2015143380A1 (en) 2014-03-20 2015-09-24 Samumed, Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
EP3122739B1 (en) * 2014-03-27 2019-01-16 Merck Patent GmbH Pyridyl piperidines
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040182A1 (en) * 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) * 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
US10350199B2 (en) 2015-08-03 2019-07-16 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
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