CL2014002511A1 - Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras. - Google Patents

Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras.

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Publication number
CL2014002511A1
CL2014002511A1 CL2014002511A CL2014002511A CL2014002511A1 CL 2014002511 A1 CL2014002511 A1 CL 2014002511A1 CL 2014002511 A CL2014002511 A CL 2014002511A CL 2014002511 A CL2014002511 A CL 2014002511A CL 2014002511 A1 CL2014002511 A1 CL 2014002511A1
Authority
CL
Chile
Prior art keywords
wnt signaling
indazole
imidazo
osteoarthritis
pyridin
Prior art date
Application number
CL2014002511A
Other languages
English (en)
Inventor
John Hood
David Mark Wallace
Sunil Kumar Kc
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49292798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002511(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of CL2014002511A1 publication Critical patent/CL2014002511A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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CL2014002511A 2012-04-04 2014-09-23 Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras. CL2014002511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261620107P 2012-04-04 2012-04-04

Publications (1)

Publication Number Publication Date
CL2014002511A1 true CL2014002511A1 (es) 2015-01-09

Family

ID=49292798

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002511A CL2014002511A1 (es) 2012-04-04 2014-09-23 Compuestos derivados de 3-(imidazo[4,5-c]piridin-2-il)-indazol, inhibidores de una o mas proteinas en la ruta de señalizacion de wnt; composicion farmaceutica; y metodo de tratamiento de un trastorno o enfermedad en que esta implicada la señalizacion aberrante de wnt tal como cancer, osteoartritis y alzheimer, entre otras.

Country Status (32)

Country Link
US (9) US8673936B2 (es)
EP (3) EP2760285B1 (es)
JP (3) JP6167169B2 (es)
KR (1) KR102048107B1 (es)
CN (2) CN104202984B (es)
AU (2) AU2013243899B2 (es)
BR (1) BR112014023639B1 (es)
CA (1) CA2853703C (es)
CL (1) CL2014002511A1 (es)
CO (1) CO7230336A2 (es)
CY (1) CY1119485T1 (es)
DK (1) DK2760285T3 (es)
ES (1) ES2635386T3 (es)
HR (1) HRP20171322T1 (es)
HU (1) HUE033829T2 (es)
IL (2) IL234743A (es)
LT (1) LT2760285T (es)
MA (1) MA37450B1 (es)
ME (1) ME02832B (es)
MX (1) MX355435B (es)
MY (1) MY174896A (es)
NZ (3) NZ727358A (es)
PE (1) PE20142216A1 (es)
PH (3) PH12017500997A1 (es)
PL (1) PL2760285T3 (es)
PT (1) PT2760285T (es)
RS (1) RS56292B1 (es)
RU (2) RU2638932C2 (es)
SG (2) SG10201610539RA (es)
SI (1) SI2760285T1 (es)
WO (1) WO2013151708A1 (es)
ZA (3) ZA201406273B (es)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
US10259817B2 (en) 2015-06-23 2019-04-16 Eisai R&D Management Co., Ltd. Crystal (6S,9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor

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JP5763072B2 (ja) * 2009-08-10 2015-08-12 サミュメッド リミテッド ライアビリティ カンパニー Ｗｎｔシグナル経路のインダゾール阻害剤およびその治療的使用
BR112012018413A2 (pt) 2009-12-21 2016-08-09 Samumed Llc 1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos.
PL2755483T3 (pl) 2011-09-14 2019-06-28 Samumed, Llc Indazolo-3-karboksyamidy i ich zastosowanie jako inhibitorów szlaków sygnalizacji WNT/B-kateniny
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
MA37577B1 (fr) 2012-05-04 2018-05-31 Samumed Llc 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques
JP6355648B2 (ja) 2013-01-08 2018-07-11 サミュメッド リミテッド ライアビリティ カンパニー Ｗｎｔシグナル伝達経路の３−（ベンゾイミダゾール−２−イル）−インダゾール阻害剤およびそれらの治療的使用
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
GB201322334D0 (en) * 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
RU2016141088A (ru) * 2014-03-20 2018-04-25 СЭМЬЮМЕД, ЭлЭлСи 5-замещённые индазол-3-карбоксамиды и их получение и применение
WO2015144290A1 (en) * 2014-03-27 2015-10-01 Merck Patent Gmbh Pyridyl piperidines
EP3166627A1 (en) 2014-07-11 2017-05-17 Genentech, Inc. Notch pathway inhibition
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017024004A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
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